Composition for lowering blood pressure and application thereof

Abstract

The invention provides a pharmaceutical composition which comprises calcium channel blockers of a medicinal dose, angiotensin II receptor antagonists of a medicinal dose, one or more of B vitamins of a medicinal dose and pharmaceutically acceptable carriers, wherein the calcium channel blockers are selected from amlodipine, felodipine, israbipine, nicardipine, nifedipine, nisoldipine, nitrendipine, lacidipine, diltiazem or verapamil; the angiotensin II receptor antagonists are selected from candesartan, telmisartan, losartan, valsartan, irbesartan, eprosartan, tasosartan or olmesartan; and the B vitamins are selected from one or more of vitamin B6, vitamin B12, folic acid and calcium leucovorin. The pharmaceutical composition of the invention can improve the curative effect of the hypotensor, enhance the target organ protecting action of the hypotensor, and reduce the morbidity of complications of angina, myocardial infarction and the like.

Description

technical field

[0001] The invention relates to a pharmaceutical composition containing a calcium channel blocker, an angiotensin II receptor antagonist and B vitamins and its application, especially a chemical drug for treating, preventing or delaying hypertension and related diseases The composition belongs to the field of pharmacy. Background technique

[0002] Essential hypertension is one of the most common chronic diseases and is the main cause of serious cardiovascular diseases such as myocardial infarction, stroke, and kidney disease. The prevalence of hypertension in my country is 18.8%, and there are more than 160 million patients at present, and the prevalence of hypertension is increasing rapidly. Elevated blood pressure is an independent risk factor for stroke and coronary heart disease, and elevated blood pressure increases the risk of heart failure and kidney disease. The main purpose of treating hypertensive patients is to minimize the total risk of cardiov...