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Biodegradable subcutaneous implant sticks for long-term blood pressure reduction

A biodegradable, long-acting technology, which is applied in the field of implant rods and biodegradable subcutaneous implant rods, can solve the problems of unstable blood pressure, difficult production process, and difficult drug release dose to meet the control standards, so as to weaken blood drug Concentration fluctuations, reducing liver toxicity, avoiding the effects of direct irritation

Active Publication Date: 2016-03-16
吕汇川
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also a long-acting antihypertensive subcutaneous injection rod disclosed, which slowly releases drugs by biodegrading the tube wall. The tube wall degrades over time, and the dose of drug release is difficult to reach the control standard, making blood pressure unstable, and its production process is not easy. accomplish

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 (can produce 110 embedding rods by the formula of the present embodiment, the diameter of embedding rod is 3mm, and length is 40mm; The weight of every embedding rod is 0.3g, and every rod contains crude drug of 0.12g)

[0026] A biodegradable subcutaneous implant rod for long-acting blood pressure reduction, which is made of the following raw materials. The implant rod includes a carrier and a raw material drug. The carrier is modified polyglyceryl sebacate, which includes sebacic acid 15 g of acid, 5 g of glycerin, 0.1 g of 1,5-pentanediol, and raw materials including 4 g of losartan, 6 g of lacidipine, 2 g of enalapril, and 1 g of metoprolol.

[0027] Processing method of the present invention comprises the following steps:

[0028] The first step, the carrier is modified polyglyceryl sebacate. The processing method is to put 15g of sebacic acid, 5g of glycerin, and 0.1g of 1,5-pentanediol into the reaction kettle, and stir while heating. When the temp...

Embodiment 2

[0031] Embodiment 2 (can produce 200 embedding rods by the formula of the present embodiment, the diameter of embedding rod is 3mm, and length is 40mm; The weight of every embedding rod is 0.3g, and every rod contains crude drug of 0.15g)

[0032] A biodegradable subcutaneous implant rod for long-acting blood pressure reduction, which is made of the following raw materials, the implant rod includes a carrier and a raw material drug, and the carrier is modified polyglyceryl sebacate, which includes capric acid Diacid 20g, glycerol 10g, 1,5-pentanediol 0.1g; raw materials include losartan 11g, lacidipine 16g, enalapril 2g, metoprolol 1g.

[0033] The processing method of the present embodiment is the same as embodiment 1.

[0034] Implementation steps of the present invention:

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Abstract

The invention provides a biodegradable subcutaneous implant rod used for long-acting pressure reduction. The biodegradable subcutaneous implant rod is a cylindrical implant rod prepared by mixing an antihypertensive drug with a biodegradable material--modified poly(glycerol-sebacate) which is used as a carrier. The implant rod is implanted into subcutaneous tissue of the human body after cobalt 60 irradiation sterilization; through slow degradation of modified poly(glycerol-sebacate), the drug is released, enters blood circulation and performs the effect of a pharmacological antihypertensive drug, and effective plasma concentration is guaranteed so as to achieve the purposes of long-term blood pressure reduction and blood pressure stabilization. The implant rod is totally degraded in one to two years, the drug is totally released at the same time, the implant rod turns into carbon dioxide, nitrogen, water and a few amount of glycerin which are absorbed by the human body and are then discharged out from the human body, so a treatment course of slow release administration is completed. The biodegradable subcutaneous implant rod can substantially reduce the attack rate of sudden cardio-cerebrovascular emergencies due to a patient misses a dose of a drug; and according to results of clinical verification, the biodegradable subcutaneous implant rod has an effective rate of 100% on primary hypertension adaptation diseases.

Description

technical field [0001] The invention relates to a long-acting antihypertensive slow-release rod for treating hypertension, in particular to a biodegradable subcutaneous implant rod for long-acting antihypertensive, which is a polysebacic acid modified by biodegradable materials Glycerol ester and antihypertensive drug are mixed to make a cylindrical implant rod; it is implanted under the human skin by subcutaneous injection, and since the drug is slowly released with the degradation of the modified polyglyceryl sebacate, the antihypertensive effect can be achieved. And the effect of stabilizing the normal range of blood pressure. Background technique [0002] At present, the treatment and stabilization of hypertension at home and abroad mainly rely on daily oral administration of antihypertensive drugs to maintain normal blood pressure. Hazards of high blood pressure Stop taking antihypertensive drugs, and it may cause a sudden increase in blood pressure when emotional and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K9/00A61K31/4422A61P9/12A61K31/4178A61K31/40A61K31/138
Inventor 吕鹏威吕汇川
Owner 吕汇川
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