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Sublingual oral preparation of torasemide

An oral preparation, torasemide technology, applied in the medical field, can solve the problems of gastrointestinal irritation, obvious first-pass effect, narrow adaptability, etc., to speed up the onset time, expand the contact area, and reduce the amount of use. Effect

Inactive Publication Date: 2017-09-15
董鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the tablet is taken orally, which is convenient for medication and has a wide range of adaptability. However, it has problems such as slow disintegration, slow onset of action, poor absorption, obvious first-pass effect, and many side effects such as gastrointestinal irritation, such as gastrointestinal bleeding, etc.
The intravenous preparation adopts the administration method of intravenous injection, and the effect can be started within 10 minutes after intravenous administration, and the peak time is 1-2 hours. , but it can only be used in hospitals, wards, intensive care units, etc., and patients cannot perform it by themselves, so the adaptability is narrow, which limits its scope of use to a certain extent

Method used

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  • Sublingual oral preparation of torasemide
  • Sublingual oral preparation of torasemide
  • Sublingual oral preparation of torasemide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The sublingual oral preparation comprises the following raw materials in parts by weight: 25 parts by weight of torasemide, 60 parts by weight of chitosan, 45 parts by weight of crospovidone, and 170 parts by weight of mannitol, which are prepared by mixing and pressing into tablets.

Embodiment 2

[0025] The sublingual oral preparation comprises the following raw materials in parts by weight: 25 parts by weight of torasemide, 50 parts by weight of cyclodextrin, 35 parts by weight of croscarmellose sodium, and 190 parts by weight of mannitol, which are mixed and compressed into tablets.

Embodiment 3

[0027] Sublingual oral preparations, comprising the following raw materials in parts by weight: 25 parts by weight of torasemide, 80 parts by weight of oleic acid, 25 parts by weight of crospovidone, 20 parts by weight of croscarmellose sodium, and 150 parts by weight of sucrose , prepared by mixing tablets.

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PUM

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Abstract

The invention discloses a sublingual oral preparation of torasemide. The sublingual oral preparation of torasemide comprises the following raw materials by weight: 15 to 35 parts of torasemide, 30 to 80 parts of a penetration enhancer, 35 to 55 parts of a disintegrating agent and 150 to 200 parts of a filler. According to the invention, a sublingual administration manner is employed for torasemide, so torasemide is prevented from entering in-vivo systemic circulation; and thus, the usage amount of torasemide is greatly lowered, and side effect of torasemide is reduced.

Description

technical field [0001] The invention relates to the field of medical technology, and more specifically relates to a method for improving the efficacy of sildenafil for treating sexual dysfunction. Background technique [0002] Torasemide is a new generation of high-efficiency loop diuretics. More than 20 years of clinical application have proved that torasemide has a wide range of indications, a rapid, strong and long-lasting diuretic effect, and a low incidence of adverse reactions. It is a high-efficiency diuretic worthy of promotion in clinical practice. agent. Its structural formula is as follows: [0003] [0004] Torsemide has diuretic, Na+ and Cl- excretion effects, but does not significantly change glomerular filtration rate, renal plasma flow and acid-base balance. It acts on the thick ascending branch of the loop of Henle, interferes with the Na+ / K+ / 2Cl- symporting system of the luminal cell membrane, inhibits the reabsorption of Cl- and Na+, increases the con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/44A61K9/20A61P7/10
CPCA61K9/006A61K9/205A61K9/2054A61K31/44
Inventor 董鹏
Owner 董鹏
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