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Biodegradable subcutaneous implant rod used for long-acting pressure reduction

A biodegradable, long-acting technology, applied in the direction of drug combination, drug delivery, active ingredients of heterocyclic compounds, etc., can solve the problems that the drug release dose is difficult to meet the control standards, the production process is not easy to achieve, and the blood pressure is unstable, etc., to achieve weakening Fluctuation of blood drug concentration, reduction of liver toxicity, and avoidance of direct stimulation

Active Publication Date: 2014-11-19
北创仙途(北京)医疗技术服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also a long-acting antihypertensive subcutaneous injection rod disclosed, which slowly releases drugs by biodegrading the tube wall. The tube wall degrades over time, and the dose of drug release is difficult to reach the control standard, making blood pressure unstable, and its production process is not easy. accomplish

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 (According to the formula of this example, 110 implant rods can be produced, the diameter of the implant rod is 3mm, and the length is 40mm; the weight of each implant rod is 0.3g, and each rod contains 0.12g of raw material medicine)

[0026] A biodegradable subcutaneous implant rod for long-term antihypertensive treatment, which is made of the following raw materials. The implant rod includes a carrier and a raw material drug. The carrier is modified polyglycerol sebacate, which includes sebacate 15g of acid, 5g of glycerin, 0.1g of pentapentanediol, and the raw materials include 4g of losartan, 6g of lacidipine, 2g of enalapril, and 1g of metoprolol.

[0027] Processing method of the present invention comprises the following steps:

[0028] The first step, the carrier is modified polyglycerol sebacate. The processing method is to put 15g of sebacic acid, 5g of glycerin, and 0.1g of pentapentanediol into the reaction kettle, and stir while heating. The hea...

Embodiment 2

[0031] Example 2 (According to the formula of this example, 200 implant rods can be produced, the diameter of the implant rod is 3mm, and the length is 40mm; the weight of each implant rod is 0.3g, and each rod contains 0.15g of raw material medicine)

[0032] A biodegradable subcutaneous implant stick for long-acting blood pressure reduction, which is made of the following raw materials. The implant stick includes a carrier and a raw material drug. The carrier is a modified polyglycerol sebacate, which includes capric acid 20 g of diacid, 10 g of glycerin, 0.1 g of pentapentanediol; raw materials include 11 g of losartan, 16 g of lacidipine, 2 g of enalapril, and 1 g of metoprolol.

[0033] The processing method of the present embodiment is the same as embodiment 1.

[0034] Implementation steps of the present invention:

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Abstract

The invention provides a biodegradable subcutaneous implant rod used for long-acting pressure reduction. The biodegradable subcutaneous implant rod is a cylindrical implant rod prepared by mixing an antihypertensive drug with a biodegradable material--modified poly(glycerol-sebacate) which is used as a carrier. The implant rod is implanted into subcutaneous tissue of the human body after cobalt 60 irradiation sterilization; through slow degradation of modified poly(glycerol-sebacate), the drug is released, enters blood circulation and performs the effect of a pharmacological antihypertensive drug, and effective plasma concentration is guaranteed so as to achieve the purposes of long-term blood pressure reduction and blood pressure stabilization. The implant rod is totally degraded in one to two years, the drug is totally released at the same time, the implant rod turns into carbon dioxide, nitrogen, water and a few amount of glycerin which are absorbed by the human body and are then discharged out from the human body, so a treatment course of slow release administration is completed. The biodegradable subcutaneous implant rod can substantially reduce the attack rate of sudden cardio-cerebrovascular emergencies due to a patient misses a dose of a drug; and according to results of clinical verification, the biodegradable subcutaneous implant rod has an effective rate of 100% on primary hypertension adaptation diseases.

Description

technical field [0001] The invention relates to a long-acting antihypertensive slow-release rod for treating hypertension, in particular to a biodegradable subcutaneous implant rod for long-acting antihypertensive, which is a polysebacic acid modified by biodegradable materials Glycerol ester and antihypertensive drug are mixed to make a cylindrical implant rod; it is implanted under the human skin by subcutaneous injection, and since the drug is slowly released with the degradation of the modified polyglyceryl sebacate, the antihypertensive effect can be achieved. And the effect of stabilizing the normal range of blood pressure. Background technique [0002] At present, the treatment and stabilization of hypertension at home and abroad mainly rely on daily oral administration of antihypertensive drugs to maintain normal blood pressure. Hazards of high blood pressure Stop taking antihypertensive drugs, and it may cause a sudden increase in blood pressure when emotional and ...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K9/00A61K31/4422A61P9/12A61K31/4178A61K31/40A61K31/138
Inventor 吕鹏威吕汇川
Owner 北创仙途(北京)医疗技术服务有限公司
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