ACE inhibitory peptide as well as synthesis method and application thereof

Abstract

The invention discloses an ACE inhibitory peptide and a synthesis method and application thereof. The ACE inhibitory peptide is artificially synthesized by means of an Aapptec396 automatic peptide synthesizer and by means of an Fmoc solid-phase synthesis method, the amino acid sequence of the ACE inhibitory peptide is Gly-Pro-Leu-Gly-Val-Pro, and it is found through detection that the IC50 value of the ACE inhibitory peptide is 105.8 mu M (P is smaller than 0.05), so that the ACE inhibitory peptide is a better-activity ACE inhibitor and can be used for preparing antihypertensive drugs.

Description

technical field [0001] The invention relates to a peptide and its synthesis method and application, in particular to an ACE inhibitory peptide, its synthesis method and application, and belongs to the field of peptide technology. Background technique [0002] Cardiovascular disease is the main cause of death in many countries and regions in the world. More than 17.5 million people die from cardiovascular disease each year. Hypertension is closely related to many cardiovascular diseases (eg arteriosclerosis, congestive heart failure, high incidence of myocardial infarction, etc.). The World Health Organization report shows that the mortality rate of hypertension ranks first in the world, about 12.8%. More than 7 million people die of hypertension-related diseases in the world every year, and 2 million people die of hypertension-related diseases in my country every year. High blood pressure may also lead to renal insufficiency and even renal failure. Hypertension is the mo...

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Problems solved by technology

[0005] At present, most of the existing ACE inhibitory peptides are extracted from animals and plants, such as: rice (a rice antihypertensive peptide and its enzymatic preparation method, CN202110297112.8), garlic (a garlic antihypertensive peptide preparation method , CN202110165787.7), yak skin (yak antihypertensive peptide and its preparation method, CN202011644080.6; antihypertensive peptide derived from yak skin and its preparation method, CN201910092409.3), square starworm (a square star Insect ACE inhibitory peptide and its preparation method, CN202011542398.3), tuna meat (a method for making tuna meat ACE inhibitory peptide chewable tablets, CN201910973746.3), sea cucumber (an ACE inhibitory active peptide derived from sea cucumber, CN201811214660 .4), catfish bone (a method for preparing antihypertensive peptide using catfish bone, CN201510499721.6), laver (a laver antihypertensive peptide and laver antihypertensive peptide extract and its application, CN201810820693.7), etc., driven The extraction of ACE inhibitory peptides from plants requires enzymatic hydrolysis of raw materials, so the extraction time is longer, and the purity of the obtained ACE inhibitory peptides is lower

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