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Compound medicine for reducing blood pressure and blood fat and preparation method thereof

A technology for antihypertensive drugs and compound prescriptions, applied in the field of antihypertensive and lipid-lowering compound drugs and their preparation, achieves the effects of good therapeutic effect, solving technical bottlenecks, and improving patient compliance

Inactive Publication Date: 2012-09-19
FOSHAN DAYI TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention aims to provide a kind of antihypertensive drug that solves the above problems in order to solve the various problems caused by the fact that the stable environment of the current thiazide antihypertensive drugs and HMG-CoA reductase inhibitors is not the same as that of making compound tablets together. Lipid-lowering compound medicine and preparation method thereof

Method used

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  • Compound medicine for reducing blood pressure and blood fat and preparation method thereof
  • Compound medicine for reducing blood pressure and blood fat and preparation method thereof
  • Compound medicine for reducing blood pressure and blood fat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 common tablet

[0024] Prepare materials according to the following quantities:

[0025]

[0026]

[0027] Preparation method: pass all components through 80 mesh sieve, mix the prescription amount of indapamide, pitavastatin calcium, potassium carbonate, potassium bicarbonate, microcrystalline cellulose, 10g sodium carboxymethyl starch, add 10% PVPK30 ethanol Appropriate amount of the solution is used to prepare soft materials, granulated with a 24-mesh sieve, dried in an oven at 50°C for 30 minutes, sieved with a 24-mesh sieve, added 10 g of sodium carboxymethyl starch, micro-silica gel, and talc powder, mixed and pressed into tablets.

Embodiment 2

[0028] Example 2 Capsules

[0029] Prepare materials according to the following quantities:

[0030]

[0031]

[0032] Preparation method: all components are passed through 80 mesh sieves, the prescription amount of pitavastatin calcium, hydrochlorothiazide, potassium bicarbonate, microcrystalline cellulose, mannitol, and 5g sodium carboxymethyl starch are mixed evenly, and an appropriate amount of 10% PVPK30 ethanol solution is added to prepare The soft material is granulated with a 24-mesh sieve, dried in an oven at 50°C for 30 minutes, granulated with a 24-mesh sieve, added with 10 g of sodium carboxymethyl starch and 2 g of magnesium stearate, mixed evenly, and filled into capsules.

Embodiment 3

[0033] Embodiment 3 double-layer sheet

[0034] Prepare materials according to the following quantities:

[0035]

[0036] Preparation method: pass all components through a 80-mesh sieve, mix the prescription amount of hydrochlorothiazide, 80g starch, 20g microcrystalline cellulose, and 10g sodium carboxymethyl starch, add 10% starch slurry to make a soft material, and granulate with a 24-mesh sieve. After drying in an oven at 50°C for 30 minutes, the granules were sieved with a 24-mesh sieve, and 2g of magnesium stearate was added for later use. Get prescription quantity atorvastatin calcium in addition, add 2.5g potassium bicarbonate, 70g starch, 60g microcrystalline cellulose, 10g sodium carboxymethyl starch, add 10% starch slurry and make soft material in right amount, granulate with 24 mesh sieves, After drying in an oven at 50°C for 30 minutes, the granules were sieved with a 24-mesh sieve, and 2 g of magnesium stearate was added for later use. The above two kinds o...

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Abstract

The invention relates to the technical field of biomedicines, in particular to a compound medicine for reducing blood pressure and blood fat and a preparation method thereof. The compound medicine for reducing blood pressure and blood fat consists of a thiazine hypotensor and a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and can simultaneously treat hypertension and hyperlipidemia; the hypotensor and a hypolipidemic are not required to be taken simultaneously; the compound medicine is used for reducing blood pressure and blood fat by synergistic effect of the thiazine hypotensor and the HMG-CoA reductase inhibitor, improves compliance of patients and reduces adverse reaction; the compound medicine has a good therapeutic effect on hypertension and hyperlipidemia in clinical trials; and moreover, the invention also provides the preparation method thereof, technical bottleneck problems are solved, the thiazine hypotensor and the HMG-CoA reductase inhibitor can be stably used in the compound medicine, respective properties of the thiazine hypotensor and the HMG-CoA reductase inhibitor are not affected, and patients suffering from hypertension and hyperlipidemia are simultaneously effectively treated.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound medicine for reducing blood pressure and fat and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards in our country, the change of diet structure, the reduction of exercise activity, the intake of cholesterol and the body mass index are all increasing. The incidence of hypertension and hyperlipidemia is increasing year by year, and the age of the onset population is gradually younger. Hypertension and hyperlipidemia are the main causes of cardiovascular and cerebrovascular diseases, and cardiovascular and cerebrovascular diseases have become the number one cause of death for middle-aged and elderly people in my country. [0003] Hypertension and hyperlipidemia are not only risk factors for cerebrovascular diseases, but also have a close relationship between them. A large number of research...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/549A61K31/404A61K31/4035A61K31/47A61K31/4709A61K31/405A61K9/24A61P9/12A61P3/06A61K31/40A61K31/366A61K31/22
Inventor 阴元魁雍智全闻亚磊陈宝林唐良伟庄东杰
Owner FOSHAN DAYI TECH LTD
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