Beta-adrenergic receptor retarder and vitamins B-containing pharmaceutical composition and applications thereof

A receptor blocker and B vitamin technology, applied in the field of pharmacy, can solve the problems of high fatality rate, disability, consumption of medical resources, etc., and achieve the effect of reducing drug side effects and target organ damage

Active Publication Date: 2013-09-04
SHENZHEN AUSA PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Hypertension is one of the most common chronic diseases, and it is also the most important risk factor for cardiovascula

Method used

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  • Beta-adrenergic receptor retarder and vitamins B-containing pharmaceutical composition and applications thereof
  • Beta-adrenergic receptor retarder and vitamins B-containing pharmaceutical composition and applications thereof
  • Beta-adrenergic receptor retarder and vitamins B-containing pharmaceutical composition and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1. prepares compound atenolol folic acid sheet (1000 pieces amount)

[0028]

[0029] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry the auxiliary materials for later use. Take 25g of atenolol and 0.4g of folic acid and mix them evenly according to the method of equal increase, and then add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose according to the prescription amount, and mix them evenly according to the method of equal increase. Mix, use 5% povidone K29 / 30-95% ethanol solution to make a soft material, granulate with a 20-mesh sieve, dry at 40°C for about 2 hours, granulate with a 18-mesh sieve, and control the water content of the granules to 2-3%. The dried granules are mixed evenly with magnesium stearate, the semi-finished product is detected, the content is measured, and it is compressed into 1000 tablets with a tablet machine. Pay attentio...

Embodiment 2

[0030] Embodiment 2. preparation compound bisoprolol 5-methyltetrahydrofolate sheet (1000 pieces amount)

[0031]

[0032] Preparation method: crush the raw and auxiliary materials through an 80-mesh sieve, and dry the auxiliary materials for later use. Take 5g of bisoprolol and 0.4g of 5-methyltetrahydrofolic acid and mix them uniformly according to the method of equal increase, and then add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose according to the prescription amount, and press etc. Mix evenly by increasing the amount, use 5% povidone K29 / 30-95% ethanol solution to make a soft material, granulate with a 20-mesh sieve, dry at 40°C for about 2 hours, granulate with a 18-mesh sieve, and control the water content of the granules to 2 -3%, the dried granules are mixed evenly with magnesium stearate, the semi-finished product is detected, and the content is measured, and compressed into 1000 tablets with a table...

Embodiment 3

[0033] Example 3. Preparation of compound metoprolol folic acid double-layer sustained-release tablets (1000 pieces)

[0034] Recipe:

[0035]

[0036]

[0037] Preparation:

[0038] (1) Metoprolol slow-release layer: mix metoprolol, hydroxypropyl methylcellulose and stearyl alcohol through an 80-mesh sieve evenly according to the prescription amount, add 5% ethyl cellulose alcohol solution to make soft Material, granulated with a 20-mesh sieve, dried at 60°C for 2 hours, granulated with an 18-mesh sieve, then added with magnesium stearate, mixed evenly, and inspected for quality.

[0039] (2) Folic acid layer: take 0.4g of folic acid, mix and sieve it with microcrystalline cellulose according to the method of equal increase, then add starch, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose, mix evenly, and use 5% polystyrene Vitone K29 / 30-95% ethanol solution to make soft material, granulate with 20-mesh sieve, dry at 40°C for about 2 hours, gr...

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Abstract

The invention relates to a beta-adrenergic receptor retarder (short for beta receptor retarder) and vitamins B-containing pharmaceutical composition which comprises effective treatment quantity of one of beta receptor retarder and an active metabolite or salt thereof, effective treatment quantity of one or more of vitamins B, and a pharmaceutically acceptable carrier, wherein the content of the beta receptor retarder and the active metabolite or salt thereof is 2.5-200mg, and the content of vitamins B is 0.1-50mg. The beta-adrenergic receptor retarder and vitamins B-containing pharmaceutical composition has the advantages that with the pharmaceutical composition, the curative effect of the beta receptor retarder on reducing the blood pressure can be enhanced, the target organ protection role of the beta receptor retarder hypotensive drugs can be enhanced, and the occurrence rate of complications such as left ventricular hypertrophy, coronary heart disease, heart failure, cerebral apoplexy, renal lesions, renal insufficiency and the like can be reduced. In addition, the pharmaceutical composition can enable patients to take conveniently, and the medical cost can be lowered.

Description

technical field [0001] The present invention relates to a pharmaceutical composition containing β-adrenoceptor blocker (abbreviated as β-adrenoceptor blocker) and B vitamins, which is used for treating hypertension, preventing or delaying the target organ caused by hypertension and other factors. Damage or reduce the risk of cardiovascular and cerebrovascular events. The present invention belongs to the field of pharmacy. Background technique [0002] Hypertension is one of the most common chronic diseases, and it is also the most important risk factor for cardiovascular and cerebrovascular diseases. High, serious consumption of medical resources, a heavy burden on the family and society. The main goal of hypertension treatment is to minimize the overall risk of cardiovascular complications and death, and it is necessary to treat all reversible cardiovascular risk factors, subclinical target organ damage, and various coexisting clinical diseases [Chinese Hypertension Preve...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61P9/12A61P9/04A61P9/10A61P13/12A61P27/02A61K31/165A61K31/403A61K31/138A61K31/714A61K31/4415A61K31/519
Inventor 徐希平张磊陈光亮王滨燕白洁王存芳
Owner SHENZHEN AUSA PHARM CO LTD
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