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Application and kit of gene SNP locus used in hypertension individual medicine treatment genetype detection

A technology for detection reagents and kits, applied in the field of molecular biology detection

Inactive Publication Date: 2019-01-15
NINGBO AJCORE BIOSCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are few studies on the association between polymorphisms on cytochrome P450, especially CYP2C19 and CYP2C19, and the antihypertensive effect of telmisartan

Method used

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  • Application and kit of gene SNP locus used in hypertension individual medicine treatment genetype detection
  • Application and kit of gene SNP locus used in hypertension individual medicine treatment genetype detection
  • Application and kit of gene SNP locus used in hypertension individual medicine treatment genetype detection

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] Research object:

[0020] A total of 285 patients with essential hypertension were recruited from three second-class / tertiary-class hospitals in Beijing, including 145 males and 140 females, aged 40-60 years (average age 52.7 years). The research subjects have obvious symptoms of hypertension with systolic blood pressure greater than or equal to 140mm Hg or diastolic blood pressure greater than or equal to 90mm Hg; currently no smoking addiction and alcoholism; according to clinical indications and physical condition, it is suitable to use telmisartan; physical examination has no other symptoms Obvious cardiovascular and cerebrovascular diseases, liver and kidney diseases, blood diseases and metabolic diseases; did not take other antihypertensive Chinese and Western medicines within two weeks before starting to take telmisartan, and did not use sartan antihypertensive drugs before entering the group.

[0021] research process:

[0022] 1 Baseline blood pressure measure...

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Abstract

The present application belongs to the field of molecular biological detection and cardiovascular and cerebrovascular diseases, specifically relates to application and kit of gene SNP locus used in hypertension individual medicine treatment genetype detection. According to the invention, a reagent for detecting SNP site genotypes on CYP2C19 and CPY3A5 is provided for use in the preparation of a kit for predicting telmisartan antihypertensive efficacy, and a combination of the corresponding kit and SNP site. A corresponding kit and SNP site combination is also provide.

Description

technical field [0001] The application belongs to the field of molecular biology detection and the field of cardiovascular and cerebrovascular diseases. Specifically, the application provides a reagent kit for detecting the genotype of the SNP site on CYP2C19 and CPY3A5 and preparing a kit for predicting the antihypertensive effect of telmisartan The application in , as well as the corresponding kit and SNP site combination. Background technique [0002] The chemical name of telmisartan is 4'-[(1,4'-dimethyl-2'-propyl[2,6'-di-1H-benzimidazole]-1'-yl)methyl Base]-[1,1'-biphenyl]-2-carboxylic acid, white or off-white crystalline powder; odorless, tasteless. Telmisartan is a non-peptide angiotensin II receptor antagonist, which can selectively and irreversibly block ATI receptors without affecting other receptor systems. For mild to moderate high blood pressure. Telmisartan is a new type of antihypertensive drug, a specific angiotensin II receptor (AT I type) antagonist, use...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/106C12Q2600/156C12Q2600/172
Inventor 周杰锋王德明
Owner NINGBO AJCORE BIOSCIENCES INC
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