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Steroid saponin pharmaceutical composition and its preparation method and uses

A technology of steroidal saponin and composition, applied in the field of steroidal saponin pharmaceutical composition, can solve the problems of environmental pollution, a large number of organic solvents, unsuitable for industrial production and the like

Inactive Publication Date: 2006-04-05
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above process has the following disadvantages: (1) low yield and high cost, (2) long production cycle, (3) a large amount of organic solvent is required, there is a risk of inflammability, explosion and toxicity in production, and it brings serious environmental pollution at the same time , (4) energy consumption is big, because the boiling point of n-butanol is high, it is difficult to concentrate and dry, (5) the product color is poor; and it is not suitable for industrialized production

Method used

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  • Steroid saponin pharmaceutical composition and its preparation method and uses
  • Steroid saponin pharmaceutical composition and its preparation method and uses
  • Steroid saponin pharmaceutical composition and its preparation method and uses

Examples

Experimental program
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Effect test

Embodiment 1

[0042] The preparation of embodiment 1 pharmaceutical composition of the present invention:

[0043] 100kg of dried rhizomes of the traditional Chinese medicine Pangosia chinensis, pulverized, refluxed with 95% ethanol (1200L × 3), 3 hours for the first time, 2 hours for the second and third times, filtered, combined extracts; recovered ethanol, added water to 2g / ml, Refrigerate for 24 hours, centrifuge; supernatant through HPD 300 The adsorption resin column is first washed with water until the effluent is colorless, and then eluted with 70% ethanol; the eluted part of 70% ethanol is received, the ethanol is recovered and concentrated to a thick extract, and then vacuum-dried to obtain the total saponins of pangolin steroid. The yield was 2.32%.

Embodiment 2

[0044] The preparation of embodiment 2 pharmaceutical compositions of the present invention

[0045] 100kg of dried rhizome of Chinese yam, sliced, decocted with 12 times (V / W) water 4 times, 3 hours for the first time, 2 hours for the second, third, and fourth times, filtered, and combined extracts; Centrifuge at room temperature; the supernatant is passed through a macroporous adsorption resin column [HPD 100 / LD 140 =7:3 (W / W)], wash with water until the effluent is colorless, then elute with 10% ethanol, and finally elute with 75% ethanol; receive the eluted part of 75% ethanol, and recover ethanol until it is free of alcohol taste, and then spray-dried to obtain the total steroidal saponins of Chinese yam with a yield of 1.15%.

Embodiment 3

[0046] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0047] 400kg of dried rhizomes of fresh pangosaurus, sliced, decocted with 8 times (V / W) water for 3 times, the first time for 3 hours, the second and third times for 2 hours each, filtered, combined extracts; put to room temperature, centrifuged; The supernatant was passed through a macroporous adsorption resin column [HPD 100 / D 101 = 6:4 (W / W)], first wash fully with water, then elute with 10% ethanol, and finally elute with 80% ethanol; receive the eluted part of 80% ethanol, recover the ethanol until it has no alcohol smell, After spray drying, the total pangolin steroid saponins were obtained with a yield of 0.56%.

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Abstract

The invention relates to a steroid glycoside medicinal composition prepared by using yellow yam and Chuanlong yam as the raw material, which comprises (by weight ratio), 5-25 parts of furostanol steroid saponin having a general formula A and / or B, and 1-10 parts of spirostanol steroid saponin 1-10 parts. The invention also provides the process for preparing the medicinal composition and its use.

Description

technical field [0001] The invention relates to a steroidal saponin pharmaceutical composition, in particular, it is a steroidal saponin pharmaceutical composition extracted from yellow yam and diosmina pennillatum as raw materials. Background technique [0002] Steroidal saponins (steroidal saponins) are a class of important biologically active substances in plants, and the study of steroidal saponins has always occupied an important position in natural product chemistry. The aglycone of steroidal saponins is spirostanol or furostanol with 27 carbon atoms, most of which are found in the single-leaved plants of Liliaceae, Amaryllidaceae and Dioscoreaceae. [0003] Yellow yam, also known as turmeric, turmeric grass, tiger ginger, and monkey festival lotus, is the rhizome of Dioscoreapanthaica Prain et Burkill, a plant of the genus Dioscorea in the Dioscoreaceae family. It is distributed in Southwest China, Hubei, Hunan and other places; Stomach gas pain, vomiting and diarrhe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/08A61K9/14A61K9/16A61K9/20A61K9/48A61P9/10A61P9/06A61P3/06
CPCA61K31/7048A61P3/06A61P9/06A61P9/10A61K2300/00
Inventor 刘忠荣祁伟付铁军邹文俊及元乔李伯刚黄瑜
Owner CHENGDU DIAO PHARMA GROUP
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