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Abiraterone acetate liquid capsule

A technology of abiraterone acetate and liquid capsules, which is applied in capsule delivery, medical preparations of non-active ingredients, endocrine system diseases, etc., can solve the problems of no abiraterone acetate liquid capsules, and achieve stable and controllable quality, The preparation process is simple and the effect of improving the dissolution rate

Active Publication Date: 2013-03-13
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is no bibliographical report that abiraterone acetate is prepared as a liquid capsule at present

Method used

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  • Abiraterone acetate liquid capsule
  • Abiraterone acetate liquid capsule
  • Abiraterone acetate liquid capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] prescription:

[0027] Abiraterone Acetate 8g

[0028] Medium Chain Triglycerides 18.4g

[0029] Glyceryl monocaprylate 73.4g

[0030] BHT0.005g

[0031] Preparation method: Dissolve the prescribed amount of abiraterone acetate and BHT in the mixture of glycerin monocaprylate and medium-chain triglycerides heated to 70°C, stir evenly, and fill them in soft capsules to prepare abiraterone acetate Bitone soft capsules, 64 soft capsules were prepared in total.

Embodiment 2

[0033] Prescription:

[0034] Abiraterone Acetate 12.5g

[0035] Medium Chain Triglycerides 43.65g

[0036] Glyceryl monocaprylate 43.65g

[0037] BHT 0.2g

[0038] Preparation method: Dissolve the prescribed amount of abiraterone acetate and BHT in the mixture of glycerin monocaprylate and medium-chain triglycerides heated to 35°C, stir evenly, and then fill and seal in soft capsules to prepare abiraterone acetate Bitone soft capsules, made 100 soft capsules altogether.

Embodiment 3

[0040] prescription:

[0041] Abiraterone Acetate 25g

[0042] Medium Chain Triglycerides 60g

[0043] Glyceryl monocaprylate 15g

[0044] BHT0.01g

[0045] Preparation method: Dissolve the prescribed amount of abiraterone acetate and BHT in the mixture of glycerin monocaprylate and medium-chain triglyceride heated to 60°C, stir evenly, and then fill and seal in soft capsules to prepare abiraterone acetate Bitone soft capsules, made 200 soft capsules altogether.

[0046]

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Abstract

The invention relates to an abiraterone acetate liquid capsule, comprising a capsule shell and contents, wherein the contents contain the components in percent by weight: 8-25% of abiraterone acetate and 74.8-91.8% of oil phase, wherein the oil phase comprises fatty acid monoglyceride and a solvent in a ratio of 1: 4 to 4: 1 by weight. The capsule disclosed by the invention does not contain a surfactant, as well as is good in dissolution rate, high in safety and simple in preparation process.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a liquid capsule of abiraterone acetate. The capsule comprises a capsule shell and contents, and the contents contain 8%-25% of abiraterone acetate and 74.8-91.8% of an oil phase, both Accounting for the weight percentage of the content, wherein the oil phase includes monoglycerides of fatty acids and solvents, and the weight ratio thereof is 1:4-4:1. The capsule prepared by the invention does not contain surfactant, has good dissolution rate, high safety and simple preparation process. Background technique [0002] Abiraterone acetate, chemical name: (3β)-17-(3-pyridyl)-androst-5,16-dien-3-ol acetate, its chemical structure is shown below. [0003] [0004] Abiraterone acetate can be converted into abiraterone in the body. Abiraterone is a cytochrome oxidase P450 (CYP450)c17 inhibitor, which reduces androgen levels by inhibiting the key enzyme in and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/58A61K47/34A61K47/14A61K47/10A61P5/28
Inventor 张涛丁彦吉张雁翎王立
Owner CHONGQING PHARMA RES INST
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