A kind of veterinary drug composition and its preparation method and application

A composition and veterinary drug technology, applied in the direction of drug combination, pharmaceutical formula, heterocyclic compound active ingredients, etc., can solve the inconvenience of drug use, slow curative effect, poisoning, such as polyether ionophore antibiotics maduramycin, monen Mycocin, salinomycin, etc.

Active Publication Date: 2020-10-27
JIANGSU LINGYUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem of the commonly used drugs for the prevention and control of existing coccidia is that the active ingredient is single, and long-term simple use causes the strains to produce drug resistance to the current commonly used drugs, causing the control effect to be greatly reduced, such as the sulfonamide anticoccidial drug sulfaquinoxaline , sulfadimethoxine, etc., pyridine drugs such as chlorpyridine (gram ball powder), etc., these two types of drugs are very prone to drug resistance; simply increasing the dose or alternating medication to improve the control effect is easy to cause Poisoning, such as polyether ionophore antibiotics maduramycin, monensin, salinomycin, etc., nitrofurans such as furazolidone (furazolidone), excessive dosage of these two types of drugs can easily cause poisoning
Traditional Chinese medicine has low toxicity and side effects and is safe to use, but the curative effect of pure Chinese medicine preparations is not as rapid as that of Western medicines, and coccidiosis often becomes an explosive infection, and pure Chinese medicine preparations cannot meet actual needs
[0005] Therefore, it is necessary to have more diversified and flexible drug application measures to solve the problem of drug resistance and even cross-resistance caused by the current commonly used drugs, the problems of inconvenient use of drugs, slow curative effect and high price, and the problems caused by drug residues. At the same time, it also solves the problem that the current coccidiosis control drugs can only treat coccidiosis to a certain extent, but are of no help to the recovery of the infected poultry and livestock.

Method used

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  • A kind of veterinary drug composition and its preparation method and application
  • A kind of veterinary drug composition and its preparation method and application
  • A kind of veterinary drug composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The raw materials were weighed according to the parts by mass of 5 toltrazuril, 15 decoxyquinate, 1 pyrantel, 15 bark of neem, 8 nepeta, 2 gallbladder, 5 atractylodes rhizome, 3 tangerine peel and 10 black plum.

[0035] Neem bark, nepeta chinensis, heart Gallbladder, Atractylodes macrocephala, tangerine peel, and black plum were powdered to 60 mesh, mixed well, and sterilized by cobalt-60 irradiation to prepare a mixture of traditional Chinese medicines.

[0036] Toltrazuril, decoquinate, pyrantel and traditional Chinese medicine mixture are mixed, food coloring is added, mixed and dried to prepare powder.

Embodiment 2

[0038] The raw materials were weighed according to the mass parts of 25 toltrazuril, 2.5 decoxyquinate, 12 pyrantel, 8 neem bark, 2 nepetae, 6 gallbladder grass, 10 atractylodes rhizome, 8 tangerine peel, and 5 ebony.

[0039] Neem bark, nepeta chinensis, heart Gallbladder, Atractylodes macrocephala, tangerine peel, and black plum were powdered to 100 mesh, mixed evenly, and sterilized with 75% ethanol to obtain a mixture of traditional Chinese medicines.

[0040] Toltrazuril, decoquinate, pyrantel and traditional Chinese medicine mixture are mixed evenly, magnesium stearate and food coloring are added, mixed evenly, dried, and compressed into tablets to prepare tablets.

Embodiment 3

[0042] The raw materials were weighed according to the parts by mass of toltrazuril 10, decoquinate 10, pyrantel 6, neem bark 12, nepeta chinensis 7, heart gallbladder 3, atractylodes rhizome 9, tangerine peel 6, and black plum 6.

[0043]Nepeta chinensis and tangerine peel are extracted by steam distillation; neem bark, heart gallbladder, Atractylodes macrocephala, and black plum are crushed, passed through a 50-mesh sieve, extracted with water 6 times the weight of the powder for 5 hours, left to stand, cooled, and the extract after filtering the residue is concentrated Make a clear paste with a relative density of 1.10-1.25 at 60°C.

[0044] Mix tortrazuril, decoquinate and pyrantel with the extracted volatile oil and clear ointment, stir thoroughly and then spray dry, add magnesium stearate to the obtained spray-dried powder, compress into tablets to prepare tablets.

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Abstract

The invention provides a veterinary drug composition. The veterinary drug composition comprises, by mass, 5-25 parts of toltrazuril, 2.5-15 parts of decoquinate, 1-12 parts of pyrantel, 8-15 parts ofCortex Meliae, 2-8 parts of Chenopodium ambrosioides, 2-6 parts of Herb of Longseed Willowweed, 5-10 parts of Rhizoma Atractylodis Macrocephalae, 3-8 parts of dried orange peel and 5-10 parts of darkplum. The invention also provides a preparation method and an application of the veterinary drug composition. The veterinary drug composition has the advantages of reasonable compatibility, quick effect, minimal toxic and side effects, effective reduction of the drug resistance and drug residues, very clear therapeutic effect on intestinal injuries, reduced appetite and lean bodies of animals, caused by coccidiosis, low cost, and easiness in use. The invention further provides the application of the composition in the treatment of histomoniasis.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a veterinary medicine composition and its preparation method and application. Background technique [0002] Coccidiosis is a common intestinal parasitic protozoan disease of poultry and livestock. It mainly parasitizes in the intestinal epithelial cells of chickens, pigeons, rabbits, pigs, and dogs. Since the intestinal tract is an important digestive and absorption organ, the parasites multiply Proliferation leads to intestinal tissue damage and thickening of the intestinal wall in poultry and livestock. The specific symptoms are: poor spirits, abdominal distension, diarrhea, blood in the stool, convulsions and even death. Because coccidiosis seriously affects the digestion and absorption of feed by poultry and livestock, the feeding efficiency is reduced, the feed remuneration is reduced, and huge economic losses are caused to poultry and livestock breeding. And the greater ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P33/02A61K31/53A61K31/47A61K31/506
CPCA61K31/47A61K31/506A61K31/53A61K36/185A61K36/284A61K36/58A61K36/736A61K36/752A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 凌青云毕亚铃蒋忠良
Owner JIANGSU LINGYUN PHARMA
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