20results about How to "Relieve diarrhea" patented technology

The invention belongs to the technical field of medicines, and provides application of Nintedanib and a plant-derived cyclic peptide and radix pseudostellariae cyclic peptide B combined medicine in preparation of a medicine for treating pulmonary fibrosis, the Nintedanib and the plant-derived cyclic peptide and radix pseudostellariae cyclic peptide B combined medicine can play a synergistic effect, and the inhibition effect on the pulmonary fibrosis process is remarkably improved. The toxic and side effects of diarrhea and intestinal mucosa injury caused by nintedanib are reduced, and a good choice is provided for clinical treatment of pulmonary fibrosis.

The invention discloses a lactobacillus rhamnosus composition for relieving gastrointestinal diarrhea and application of the lactobacillus rhamnosus composition, the composition is composed of a probiotic mixture, a prebiotic mixture and a carrier, the probiotic mixture is composed of lactobacillus plantarum JY055 bacterial powder, lactobacillus rhamnosus JM039 bacterial powder and lactobacillus rhamnosus JY027 bacterial powder, and the prebiotic mixture is composed of lactobacillus plantarum JY055 bacterial powder, lactobacillus rhamnosus JM039 bacterial powder and lactobacillus rhamnosus JY027 bacterial powder. The prebiotic mixture comprises inulin, xylitol, lactulose, resistant dextrin, a hawthorn extract and a dandelion extract, and the carrier is modified montmorillonite. The composition for relieving gastrointestinal diarrhea provided by the invention is composed of a mixture of three probiotics and prebiotics, and the probiotics are adhered to small intestinal mucosa epithelial cells to form a mycoderm and form an intestinal barrier, so that colonization and growth of harmful bacteria are prevented, self-protection of intestinal epithelial cells is enhanced, and the damaged intestinal barrier is repaired; the prebiotic mixture provides a breeding place and nutrient elements for growth and breeding of the probiotics, and the efficacy can be improved through mutual cooperation of the prebiotic mixture and the probiotics.

The invention belongs to the technical field of food industry, and particularly relates to a method for preparing metabiotics from fermented supernate and application. The invention provides a preparation method of metabiotics, which comprises the following steps: mixing lactobacillus fermentation supernate with a carbon source to obtain first feed liquid; and inoculating lactic acid bacteria into the first feed liquid for culturing to obtain the metabiotics. According to the method disclosed by the invention, the waste of the lactobacillus fermentation supernatant is used as a main raw material, so that the reutilization of the lactobacillus fermentation supernatant is realized, and residual proteins, saccharides, vitamins and other nutrients in the supernatant are used for carrying out secondary fermentation culture to prepare the metabiotics; meanwhile, in consideration of relative lack of nutritional ingredients in the supernate, a carbon source is added to enrich nutrition in the supernate, and the prepared metagen is high in thallus content and has the effects of relieving constipation and diarrhea, improving immunity, resisting oxidation (delaying senescence), relieving pressure, promoting sleep, inhibiting bacteria and the like.

The invention discloses bifidobacterium longum subsp. Infantis i18 with an effect of regulating intestinal flora and application of the bifidobacterium longum subsp. Infantis i18, and belongs to the technical field of microbial engineering. The bifidobacterium longum subsp. Infantis i18 strain is preserved in the China General Microbiological Culture Collection Center, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, the preservation date is July 25, 2024, the preservation number is CGMCC NO.31411, and the Latin name is Bifidobacterium longum subsp. Infantis. The invention also discloses a preparation method of the bifidobacterium longum subsp. Infantis strain. The bifidobacterium longum subsp. Infantis i18 provided by the invention has a bidirectional regulation effect, can relax bowel, relieve diarrhea, maintain intestinal steady state and regulate intestinal flora at the same time, expands the application range of the bifidobacterium longum subsp. Infantis, and enriches the types of the domestic bifidobacterium longum subsp. Infantis. The preparation method is suitable for preparing the probiotic agent or the infant formula milk powder.

The invention discloses an electrolyte balance regulator for low-protein daily ration of piglets. The electrolyte balance regulator comprises the following components in parts by weight: 40-54 parts of potassium sulfate, 27-40 parts of sodium bicarbonate, 2-30 parts of potassium-containing zeolite and 2-4 parts of hydrotalcite. The addition amount of the electrolyte balance regulator in the low-protein low-soybean-meal feed for the piglets is 0.2 wt.%-0.5 wt.%. The hydrotalcite used in the invention can relieve the adverse effect of high Cl <-> of low-protein low-soybean-meal daily ration on piglets, and both zeolite and hydrotalcite can improve the bioavailability of potassium and sodium. According to the electrolyte balance regulator disclosed by the invention, all the components have a remarkable interaction effect and a positive remarkable synergistic combination effect, and the acid-base balance and electrolyte balance of piglets can be effectively regulated by adding the electrolyte balance regulator disclosed by the invention into a low-protein low-soybean-meal feed through the optimal proportion and the combined synergistic effect of all the components; the piglet diarrhea is obviously relieved, the growth performance of piglets is improved, the intestinal health of the piglets is improved, the digestion and absorption of crude protein of the feed are improved, and the efficient absorption and utilization of amino acid are promoted.

The invention discloses a voglibose suspension and a synthesis process thereof. The formula of the voglibose suspension comprises voglibose, hydroxypropyl methyl cellulose, purified water, calcium stearate, lauryl sodium sulfate and a solvent. The synthesis process comprises the following steps: step 1, preparation work; step 2, preparing a liquid medicine; step 3, sieving treatment; 4, mixing the medicinal powder; step 5, preparing suspension liquid; step 6, mixing liquid medicine; and step 7, packaging and storing. The voglibose suspension is designed, purified water is heated to dissolve voglibose and hydroxypropyl methyl cellulose, calcium stearate and polydextrose are added after the voglibose and the hydroxypropyl methyl cellulose are dissolved, and the calcium stearate can promote gastrointestinal motility so as to promote absorption of a patient to the medicine; hydroxypropyl methyl cellulose has thickening and polymerization effects and can prolong the drug effect time, and polydextrose can generate special physiological metabolism to relieve diarrhea caused by metabolic disorder after entering a human body.

The invention provides a composite black fungus blood fat reducing product formula and a preparation method thereof, and belongs to the technical field of biology. On the first aspect, the invention provides a formula of a composite black fungus product for reducing blood fat, and the formula of the composite black fungus product for reducing blood fat comprises the following components: black fungus enzymolysis macromolecules, an active activator, a mulberry leaf extract and trehalose; secondly, the invention provides a preparation method of the composite black fungus blood fat reducing product. Thirdly, the invention provides a preparation method of the black fungus enzymolysis macromolecules. In the fourth aspect, the invention provides a preparation method of raspberry fermentation broth freeze-dried powder.

The invention discloses an application of intestinal symbiotic bacteria in preparation of products for preventing and treating colorectal cancer. The intestinal symbiotic bacteria are ruminococcus flavus or succinic acid producing filamentous bacteria. The method has the beneficial effects that the intestinal flora balance can be regulated; the intestinal barrier function can be enhanced; the immunoregulation effect is achieved; the effect of comprehensively preventing and treating colorectal cancer is achieved.

The invention belongs to the technical field of biological medicines, and particularly relates to application of atractylodes macrocephala polysaccharide to prevention and treatment of diarrhea caused by a tyrosine kinase inhibitor. Specifically, research finds that atractylodes macrocephala polysaccharide inhibits CFTR-mediated chloride ion secretion in cells treated by a tyrosine kinase inhibitor pyrrotinib. A certain dose of rhizoma atractylodis macrocephalae polysaccharide can relieve rat diarrhea caused by pyrrotinib and remarkably recover the intestinal barrier function. The rhizoma atractylodis macrocephalae polysaccharide treatment improves the distribution of intestinal microorganisms, and the level increase of clostridium difficile and erysipelothrix caused by pyrrotinib is recovered. In a word, the invention provides a thought for the specific mechanism of the atractylodes macrocephala polysaccharide for relieving the diarrhea caused by the pyrrotinib, provides an insight for the complex interaction between the atractylodes macrocephala polysaccharide and intestinal microbiota, and provides a possible strategy for treating the diarrhea caused by the pyrrotinib by using the atractylodes macrocephala polysaccharide, so that the atractylodes macrocephala polysaccharide has a good practical application value.

The invention discloses a traditional Chinese medicine composition capable of relieving diarrhea caused by cryptosporidium parvum as well as a preparation method and application of the traditional Chinese medicine composition, and belongs to the technical field of medicines. The traditional Chinese medicine composition consists of a prescription for clearing intestines and resolving dampness and allicin, the prescription for clearing intestines and resolving dampness is composed of scutellaria baicalensis, coptis chinensis, roasted radix aucklandiae, fried angelica sinensis, sanguisorba officinalis, parched white peony root, angelica dahurica and liquorice. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of radix scutellariae, 6-10 parts of rhizoma coptidis, 6-10 parts of roasted radix aucklandiae, 10-15 parts of fried radix angelicae sinensis, 10-15 parts of radix sanguisorbae, 15-20 parts of fried radix paeoniae alba, 10-20 parts of radix angelicae, 6-10 parts of liquorice root and 0.02-0.07 part of allicin. The traditional Chinese medicine composition prepared by the invention is efficient, low in toxicity, safe and harmless, and can relieve diarrhea caused by cryptosporidium parvum, relieve intestinal injury, regulate the composition structure of intestinal flora and enhance intestinal barrier and immunity.

The invention discloses a traditional Chinese medicine oral prescription for preventing and treating influenza A and improving digestive tract diseases, and belongs to the technical field of traditional Chinese medicines. The prescription is prepared from kudzuvine root, radix bupleuri, moutan bark, peach kernel, scutellaria baicalensis, raw rhubarb, pinellia ternate, fructus forsythiae, mirabilite, mangnolia officinalis, immature bitter orange, poria cocos, bighead atractylodes rhizome, rhizoma alismatis, white paeony root, Chinese date and ginger which are strictly matched according to a specific weight ratio and are prepared by a specific water decoction process. The traditional Chinese medicine oral prescription can effectively prevent and treat influenza A through the synergistic effect of the components, has a remarkable improvement effect on most of digestive tract diseases, is simple in preparation process, convenient to take and high in safety, avoids the problems of poor curative effect, obvious side effect or narrow application range and the like of related medicines in the prior art, and has a wide application prospect. And a new effective choice is provided for prevention and treatment of influenza A and improvement of digestive tract diseases.

The invention discloses a preparation method of galactomannan and application of the galactomannan in relieving diarrhea, and belongs to the technical field of biological medicines.The preparation method comprises the steps that guar gum is subjected to composite enzymolysis, centrifugation, enzyme deactivation, impurity removal and ultrafiltration, and the galactomannan with the specific molecular weight (10000-20000 Da) is obtained. Animal experiments prove that the galactomannan can quickly and effectively relieve diarrhea symptoms of mice and weaned piglets, the diarrhea index and the water sample amount of the mice can be remarkably reduced within 2 hours after intervention on the diarrhea mice, meanwhile, the intestinal barrier of the mice can be effectively consolidated, intestinal moisture absorption is promoted, intestinal flora is adjusted, and the diarrhea resistance of the mice and the weaned piglets is improved. The invention provides special and effective novel prebiotics for the treatment of diarrhea, and provides a theoretical basis for the practical application of galactomannan.

The invention provides compound probiotics for relieving diarrhea and soft stool of pets and application of the compound probiotics. The compound probiotics comprise lactobacillus acidophilus ZYpet-009 (the preservation number is CGMCC No. 31559) and saliva combined lactobacillus ZYpet-010 (the preservation number is CGMCC No. 31560). According to the invention, the two bacteria are compounded and can be matched and promoted with each other, and have synergistic interaction in the aspects of relieving diarrhea and soft stool of pets, specifically, the animal diarrhea is remarkably relieved, the anti-inflammatory and intestinal immune functions of animals are improved, the soft stool of the animals is remarkably improved, and colonization and reproduction of pathogens in intestinal tracts are inhibited.

The present invention belongs to the field of biomedicine technology, and specifically relates to the application of Atractylodes macrocephala polysaccharide in preventing and treating diarrhea caused by tyrosine kinase inhibitors. Specifically, the present invention has found through research that Atractylodes macrocephala polysaccharide inhibits CFTR-mediated chloride ion secretion in cells after treatment with the tyrosine kinase inhibitor pyrotinib. A certain dose of Atractylodes macrocephala polysaccharide can alleviate diarrhea in rats caused by pyrotinib and significantly restore intestinal barrier function. Atractylodes macrocephala polysaccharide treatment improves the distribution of intestinal microorganisms and restores the increased levels of Clostridium difficile and Erysipelothrix caused by pyrotinib. In short, the present invention provides ideas for the specific mechanism of Atractylodes macrocephala polysaccharide in alleviating diarrhea caused by pyrotinib, provides insights into the complex interactions between Atractylodes macrocephala polysaccharide and intestinal microbiota, and provides a possible strategy for using Atractylodes macrocephala polysaccharide to treat diarrhea caused by pyrotinib, and therefore has good practical application value.

The present invention provides a composite probiotic for relieving diarrhea and soft stool in pets and its application, wherein the composite probiotic comprises Lactobacillus acidophilus ZYpet‑009 (with a deposit number of CGMCC No. 31559) and Lactobacillus salivarius ZYpet‑010 (with a deposit number of CGMCC No. 31560). The present invention finds that the composite of the two bacteria can cooperate with each other, promote each other, and synergize in relieving diarrhea and soft stool in pets, which is specifically manifested in: significantly relieving animal diarrhea, improving animal anti-inflammatory and intestinal immune functions, significantly improving animal soft stool, and inhibiting the colonization and reproduction of pathogens in the intestine.

The invention discloses a composition for treating diarrhea caused by rotavirus infection in pet dogs and cats. The composition comprises the following components: 5-18 parts by weight of echinacea extract, 1-6 parts by weight of bacillus subtilis spore powder, 10-35 parts by weight of beta-glucan, 5-18 parts by weight of sodium chondroitin sulfate, 2-10 parts by weight of N-acetylglucosamine, 2-10 parts by weight of gamma-aminobutyric acid, 10-35 parts by weight of lactobacillus plantarum fermentation product, 5-18 parts by weight of D-mannitol, and 5-18 parts by weight of magnesium hydroxide. A preparation method and application of the composition in preparing a medicament for treating rotavirus diarrhea in pet dogs and cats are also disclosed. The composition cleverly utilizes the synergistic effects of the components in anti-virus, immune regulation, intestinal mucosal repair, diarrhea improvement, etc., and exhibits an excellent effect of treating rotavirus diarrhea in pets through comprehensive regulation of multiple links such as immunity, barrier, flora, mucosa, etc.

This invention relates to an experimental puppy food, comprising: 10-30 parts puffed corn, 1-5 parts puffed soybean meal, 15-30 parts puffed rice flour, 25-40 parts chicken meal, 3-10 parts olive oil, 3-10 parts duck fat, 0.5-1 part limestone powder, 0.02-0.05 parts choline chloride, 0.1-0.3 parts sodium chloride, 1-4 parts chicken liver powder, 4-8 parts beef flavoring agent, 4-8 parts milk powder, and 3-4 parts multivitamin and mineral premix; it also includes inactivated probiotics, with 1-6g of inactivated probiotics added per kg of puppy food, the inactivated probiotics including Pediococcus lactis CGMCC No. 23551; and it also includes Eucommia ulmoides leaf extract, with 4-12g of Eucommia ulmoides leaf extract added per kg of puppy food. The experimental puppy food mentioned above was fortified with inactivated probiotics and plant extracts to improve the intestinal microecological balance of the experimental dogs, increase the digestibility and utilization of the dog food, and enhance the stress resistance of the puppies. The prepared dog food has low hardness, making it easy for puppies to eat during the weaning transition period and reducing stress. The milk powder uses an external spray coating process to enhance the immune function of the experimental puppies, and nitrogen packaging helps to preserve the feed.

The invention provides an application of a compound agilawood extract in preparation of a foot bath bag, the compound agilawood extract comprises an agilawood extract, a sea grape extract and an eclipta extract in a mass ratio of (3-6): 1: (2-4), and the foot bath bag can be used as a skin roughness inhibitor and a diarrhea ameliorant. Compared with the prior art, the aquilaria wood extract, the sea grape extract and the herba ecliptae extract are creatively combined and applied to the foot bath bag to serve as a skin roughness inhibitor for enhancing the expression of caspase 14 and a diarrhea improving agent for enhancing the expression of sucrase-isomaltase, and the effects of well removing cutin and improving diarrhea can be achieved. And the traditional Chinese medicine composition can inhibit rough skin and relieve uncomfortable symptoms such as diarrhea, and has a wide application prospect.

The invention belongs to the technical field of feed additives, and particularly relates to a weaning young rabbit compound micro-ecological complete feed formula and a preparation method, and the weaning young rabbit compound micro-ecological complete feed formula comprises the following components: 15.272 parts of wheat flour, 5 parts of glucose, 0.35 part of vitamin and mineral substance, 14.78 parts of soybean meal, 16 parts of rice bran, 45.56 parts of alfalfa, 0.01 part of vitamin C, 0.1 part of calcium bicarbonate, 0.708 part of bentonite, 0.35 part of calcium carbonate, 0.25 part of sodium chloride, 1.43 parts of soybean oil, 0.14 part of methionine, 0.05 part of choline chloride, and a compound micro-ecological additive; the compound micro-ecological additive is prepared from 108 to 1013cfu of rabbit source lactobacillus plantarum, 108 to 1013cfu of lanthanum-containing rabbit source lactobacillus plantarum and 100mg of vitamin C in terms of each kilogram of complete feed. The traditional Chinese medicine composition can regulate the form of intestinal tracts, solve the problem of diarrhea and improve the health of the intestinal tracts.

The invention belongs to the technical field of medicines, and discloses application of triton in preparation of food or medicines for preventing or treating colitis. Experimental research on a dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) mouse model shows that the Qula can remarkably slow down the weight loss rate of the UC mouse, reduce the disease activity index (DAI) and effectively improve pathological changes of colon tissue. In addition, the Qula can also regulate the imbalance of intestinal flora, and provides a new thought and basis for the development of ulcerative colitis treatment products.