Medicine for curing constipation and its preparing method

A technology for treating constipation and drugs, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc. It can solve problems such as unsatisfactory effects, long soaking time, and weakened drug effects, and achieve high bioavailability of drugs , quick effect, easy to use

Inactive Publication Date: 2002-08-21
HEBEI HENGLI GRP PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rhubarb Gancao Decoction is a water decoction, and the effect is not ideal after clinical application. This is because the laxative effect of rhubarb is directly proportional to the glycosides in rhubarb, and the anthraquinone glycosides in it are easily hydrolyzed during the extraction process, which makes the effect less effective. Weaken (Jiangsu New Medical College, Canon of Traditional Chinese Medicine, p. 83, 1977, Shanghai People's Publishing House)
There is also a proposal to use cooked rhubarb and licorice as raw materials to make tea (CN1094622A). This tea needs to be taken with boiling water. Because the water temperature is high and the soaking time is long, the drug effect will also be weakened due to the hydrolysis of the active ingredient anthraquinone glycosides.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0037] This example is to prepare capsules, and the preparation process is as follows:

[0038] 300 g of rhubarb and 30 g of licorice extract were dried at 100° C. until the water content was below 8%. Pulverize and pass through an 80-mesh sieve, and 10 g of starch pass through an 80-mesh sieve. The rhubarb, licorice extract and starch are fully mixed, tested and packed into capsules to make 1000 capsules.

example 2

[0040] This example is to prepare granules, and the preparation process is as follows:

[0041] Sieve 900g of rhubarb, 90g of licorice extract, and appropriate amount of sucrose in a 100°C mesh sieve, mix evenly, add 95% alcohol to make a soft material, granulate with a 16-mesh sieve, dry at 60-70°C, and granulate with a 14-mesh sieve , testing, packaging, and made into 1000 bags.

example 3

[0043] This example is to prepare tablet, and the preparation process is as follows:

[0044] Dry and pulverize 300g of rhubarb, 30g of licorice extract and pulverize, pass 10g of starch through a 100-mesh sieve, mix them well, make soft material with 95% alcohol, granulate with a 16-mesh sieve, then dry at 60-70°C, pass through Sieve through a 14-mesh sieve, add 1g of magnesium stearate and mix, punch and coat with φ10mm to obtain 1000 tablets.

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PUM

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Abstract

The medicine for treating consitipation is capsule, tablet and granule prepared with rhubarb and licorice extractum. The method of the present invention has the functions of clearing away heat, relieving intestinal stasis and purgation. It has the features of high biological utilization, fast effect, no toxic side effect and negative reaction. Clinical application shows that it has a total effective rate as high as 98%.

Description

technical field [0001] The invention relates to a medicine for treating constipation, in particular a Chinese patent medicine made from Chinese herbal medicines. Background technique [0002] Constipation is a common and frequently-occurring disease, especially in the elderly and some young and middle-aged people. At present, domestic laxatives include Diacefentin, Guodao Tablets, Tongbianning and Wansaiting, etc., but these drugs are difficult to satisfy different types of constipation caused by various reasons. Ancient Chinese medical books have long had a prescription "Dahuang Gancao Decoction" for treating constipation (Synopsis of the Golden Chamber, volume, page 19, Zhonghua Book Company Juzhen imitation Song edition). Rhubarb Gancao Decoction is a water decoction, and the effect is not ideal after clinical application. This is because the laxative effect of rhubarb is directly proportional to the glycosides in rhubarb, and the anthraquinone glycosides in it are easil...

Claims

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Application Information

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IPC IPC(8): A61P1/10
Inventor 赵俊山赵毅明刘丽平孙爱君李新联
Owner HEBEI HENGLI GRP PHARM CO LTD
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