Medical composite for treating livestock and poultry intestinal canal diseases and preparation method and application thereof

Abstract

The invention discloses a medical composite for treating livestock and poultry intestinal canal diseases and a preparation method and an application thereof, aiming at providing a medical composite and the preparation method and the application thereof, which can fast and effectively prevent and cure intestinal canal diseases. The composite comprises the following components in weight percent, 2%to 5% of pirquinozol antibiotics, 3% to 10% of beta-lactam antibiotics, 0.6% to 2% of beta-lactam inhibitor, 3% to 10% of aminoglycoside antibiotics and the balance auxiliary material acceptable in pharmacy. The pirquinozol antibiotics, such as norfloxacin lactate, is broad-spectrum antibiotics; the beta-lactam inhibitor has the functions of inhibiting enzyme and strengthening the effect; and thebeta-lactam antibiotics can destroy bacterial cell walls, which is favorable for aminoglycoside antibiotics to enter cells to take effect, increases the antibacterial effect and simultaneously enlarges the antibacterial spectrum. The composite of the invention can effectively cure canal diseases caused by Gram negative bacteria or anaerobe and the mixed infection of the Gram negative bacteria andthe anaerobe.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating intestinal diseases of livestock and poultry, a preparation method and application thereof. Background technique [0002] In recent years, livestock and poultry intestinal diseases such as poultry colibacillosis, chicken pullorum, enteritis, piglet pullorum or piglet yellow diarrhea have occurred frequently, and are generally intestinal inflammation caused by Gram-negative bacteria or anaerobic bacteria. Week-old broilers raised on litter and chickens 7-12 weeks old are more common. The clinical manifestations of sick chickens are depression in varying degrees, loss of appetite, reluctance to walk around, black or bloody feces, and disheveled feathers. The course of the disease is short, and it is often only seen in acute death of sick birds. Pathological changes are often limited to the small intestine, more common in the jejunum and ileum, and occasionally cecal lesions can be seen....

AI Technical Summary

Problems solved by technology

However, at present, the country has promulgated some drug catalogs that are allowed to be used in food, which limits the use of drugs such as metronidazole. Dysentery has a certain effect on intestinal diseases, and has no adverse effects on chickens and pigs in therapeutic doses. However, due to poultry It is sensitive to it, and when the dosage is 3-5 times higher than the clinical treatment amount, or prolonged application can cause toxic reactions and even death

Therefore, the use of this product is greatly limited

In addition, for colibacillosis, etc., due to the long time of medication, the bacteria are prone to drug resistance, and generally a single antibacterial drug is difficult to work, resulting in treatment failure