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Application of cellulose derivative in preparation of medicine for treating ulcerative colitis

A technology of cellulose derivatives and ulcerative colitis, which is applied in the application field of cellulose derivatives in the preparation of drugs for treating ulcerative colitis, can solve the problems of large side effects and high cost of ulcerative colitis drugs, and achieve relief of colonic inflammation. Effects of shortening, resisting inflammatory cell infiltration and erosion in mouse colon tissue, and inhibiting weight loss

Pending Publication Date: 2022-06-28
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of this, in order to solve the problems of high cost and side effects of ulcerative colitis drugs in the prior art, the present invention proposes the application of cellulose derivatives in the preparation of drugs for treating ulcerative colitis, HPC, HEC, Derivatives of cellulose such as CMC-Na are easy to obtain, and have no toxic and side effects as safe pharmaceutical excipients, which is conducive to reducing the production cost of colitis drugs and improving patient compliance

Method used

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  • Application of cellulose derivative in preparation of medicine for treating ulcerative colitis
  • Application of cellulose derivative in preparation of medicine for treating ulcerative colitis
  • Application of cellulose derivative in preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 The effect of hydroxypropyl cellulose (LHPC, HHPC) on the disease activity index of ulcerative colitis Blab / c male mice

[0036] There were four groups of hydroxypropyl cellulose, 6 mice in each group, and each group of mice received 150 mg / KG or 300 mg / KG LHPC and HHPC aqueous solution orally, and freely drank 2.5% (w / v) DSS aqueous solution. Mice in the model group drank 2.5% (w / v) DSS aqueous solution freely, mice in the normal group drank clean distilled water freely, and the two control groups took an equal volume of normal saline for control. The experimental period was 8 days, and the state of each group of mice was observed and the body weight and feces data were recorded every day.

[0037] The disease activity index includes the weight loss score, fecal trait score and blood in the stool severity score of the mice. The total score is the average of the three indicators, and is evaluated according to the following table 1:

[0038] Table 1 Disease ac...

Embodiment 2

[0041] Example 2 The effect of hydroxyethyl cellulose (HEC) and sodium carboxymethyl cellulose (CMC-Na) on the disease activity index of ulcerative colitis Blab / c male mice

[0042] The dosage of the tested drug, the construction of the mouse model, and the administration method were the same as those in Example 1. The result is as figure 2 As shown, the mice developed bloody stool and diarrhea after DSS modeling, and 150mg / KG and 300mg / KG of HEC and CMC-Na could reduce the disease activity index and improve the fecal score of colitis mice. In comparison, 300mg / KG HEC and CMC-Na had better effect.

Embodiment 3

[0043] Example 3 The effect of hydroxypropyl cellulose (LHPC, HHPC) on the body weight of Blab / c male mice with ulcerative colitis

[0044] The dosage of the tested drug, the construction of the mouse model, and the administration method were the same as those in Example 1. The body weight was taken as 100% on the 0th day, and the weight change was calculated in a percentage system on this basis.

[0045] like image 3 As shown, the body weight of mice continued to decrease after DSS modeling. LHPC and HHPC at both doses had significant effects on body weight maintenance in mice with colitis, and there was no significant difference in body weight changes in each HPC treatment group.

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Abstract

The invention relates to the field of medicines, in particular to application of a cellulose derivative in preparation of a medicine for treating ulcerative colitis. Pharmacodynamic tests prove that when the cellulose derivative represented by HPC, HEC and CMC-Na is orally taken, the weight loss of mice with colitis induced by dextran sodium sulfate (DSS) is inhibited, the fecal character and hematochezia condition of the UC mice are improved, and the intestinal tissue pathological injury of the UC mice can be effectively treated. Meanwhile, the oral administration of HPC improves the microbial diversity of intestinal flora of mice with colitis. Therefore, the cellulose derivative represented by HPC can be used as a dietary fiber for regulating and controlling intestinal flora, and symptoms of ulcerative colitis can be improved. The medical application of the cellulose derivative is broadened, a new therapeutic drug is provided for UC treatment, and the cellulose derivative has non-negligible clinical significance.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of cellulose derivatives in the preparation of medicaments for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC), first reported in the mid-19th century, is characterized by persistent and diffuse inflammation from the colonic mucosa to the proximal rectum. The pathogenesis of UC has not been scientifically proven, and it is often referred to as intestinal inflammatory disease together with Crohn's disease, and its typical clinical symptoms are blood in the stool, diarrhea, and weight loss. Most patients present with intermittent chronic diseases and recurrent attacks, and their work and life are severely disturbed and tortured. Epidemiological studies at UC show that the incidence of the disease is rapidly increasing in North America and Northern Europe, and is currently increasing in Asia such as India and Japan. There are a variety ...

Claims

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Application Information

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IPC IPC(8): A61K31/717A61K45/06A61P1/04A23L33/125
CPCA61K31/717A61K45/06A61P1/04A23L33/125A23V2002/00A61K2300/00A23V2200/32
Inventor 吕慧侠张振海李雪锋
Owner CHINA PHARM UNIV
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