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Probiotic composition capable of relieving or treating travel diarrhea and application thereof

A technology of probiotics and compositions, applied in the field of probiotics compositions, can solve the problems of superinfection, destroying the balance of normal intestinal flora and the like

Pending Publication Date: 2020-08-28
金华银河生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of this application is to provide a probiotic composition that can alleviate or treat traveler's diarrhea and its application, so as to solve the problem that the use of antibiotics to treat diarrhea destroys the balance of normal intestinal flora and causes superinfection

Method used

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  • Probiotic composition capable of relieving or treating travel diarrhea and application thereof
  • Probiotic composition capable of relieving or treating travel diarrhea and application thereof
  • Probiotic composition capable of relieving or treating travel diarrhea and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] Experimental Example 1 Establishment of a clinical trial of probiotic solid beverages intervening in a population with traveler's diarrhea

[0025] 1. The probiotics Bifidobacterium lactis Probio-M8 and Lactobacillus plantarum intervene in the human trial of traveler's diarrhea. In the case of complete ethics and morality, volunteers are treated and studied. The experiments are divided into A, B, C, and G Four groups, in which group G is the placebo group, and group A, B, and C are the experimental groups. The specific selection criteria for human experiment volunteers are shown in Table 1, and the specific grouping details are shown in Table 2.

[0026] 2. The method of taking the probiotic solid drink: dissolve the probiotic solid drink in warm water, milk or take it directly, take it once a day after meals (1.0×10 11 CFU / time), taking continuously for 21 days.

[0027] 3. In the solid drink, both the placebo group and the experimental group contained maltodextrin a...

Embodiment 2

[0033] Example 2 Defecation Frequency Record of Probiotic Solid Beverage Intervention Treatment of Traveler's Diarrhea Human Experiment

[0034] The evaluation criteria for human trials of probiotics Bifidobacterium lactis Probio-M8 and Lactobacillus plantarum intervened in the treatment of traveler's diarrhea. Specifically, the inclusion criteria for patients with diarrhea refer to the Rome III criteria for irritable bowel syndrome (IBS), as shown in Table 3.

[0035] The uniformly trained recorder asked and recorded the patient's defecation frequency and stool shape every 3 days, and then counted the weekly defecation frequency according to the following formula. The description of the stool shape corresponds to Table 3.

[0036] Weekly defecation frequency (times / week) = 3 / 7× defecation frequency (within 3 days)

[0037] Table 3. Rome Criteria III and IBS Subtype Classification

[0038]

[0039] During the test period, the defecation frequency and stool shape of the sub...

Embodiment 3

[0040] Example 3 Detection of intestinal flora in human experiment of probiotic solid drink intervention treatment of traveler's diarrhea

[0041] Take 2-5g of feces from patients before and after the test, put them in a closed anaerobic tank, and send them to the laboratory immediately under refrigeration to detect the number of viable bacteria of Bifidobacterium, Escherichia coli, Enterococcus, Bacteroides, and Bacillus aerogenes. Take 1 g of feces, add 9 mL of PBS buffer solution, and then add sterile glass beads to fully shake as a 1:10 test solution, and then make serial 10-fold dilutions (10 -2 ~10 -9 ). Take 100 μL of a suitable concentration of bacteria-containing solution and spread it on a selective medium suitable for the growth of Bifidobacterium, Escherichia coli, Enterococcus, sphaerozoccus, and Bacillus aerogenes, and make 3 parallels for each dilution. Cultivate under aerobic or anaerobic conditions for 48 hours (including Escherichia coli and Enterococcus fo...

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Abstract

The invention discloses a probiotic composition capable of relieving or treating travel diarrhea and an application thereof. The probiotic composition is prepared from bifidobacterium lactis Probio-M8and lactobacillus plantarum. By tracking and detecting the content of effective microorganisms in the intestinal tracts of traveling crowds, it is proved that the probiotic composition, such as a probiotic composite solid beverage, can balance intestinal microecology, so that the effect of relieving diarrhea is achieved, and particularly the probiotic composition plays a positive role in relieving and treating travel diarrhea.

Description

technical field [0001] The application relates to the field of biotechnology, in particular to a probiotic composition capable of alleviating or treating traveler's diarrhea and its application. Background technique [0002] Diarrhea, commonly known as "diarrhea", refers to the frequency of defecation significantly exceeding daily habits, thin fecal matter, increased water content, daily defecation volume exceeding 200g, or containing undigested food or pus, blood, and mucus. Clinically, diarrhea is often accompanied by symptoms such as urgency to defecate, anal discomfort, and incontinence. Usually, infection with pathogens such as bacteria, viruses or parasites is the main cause of diarrhea. This part of diarrhea is also called infectious diarrhea or gastroenteritis. The occurrence and spread of infectious diarrhea are considered to be caused by poor hygiene conditions. the result of. With the development of society, travel or business trip is one of the lifestyles that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61P1/12A23L33/135A23L11/00A23C9/123A23L19/00A61K35/745
CPCA61K35/745A61K35/747A61P1/12A23L33/135A23C9/1234A23L19/00A23V2002/00A23L11/50A23V2400/531A23V2400/169A61K2300/00A23V2200/3204
Inventor 刘晓军马杰包维臣张凌宇张建军其木格苏都杨慧娟
Owner 金华银河生物科技有限公司
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