The invention discloses kidney-tonifying, collateral-dredging and brain-nourishing paste and a preparation method thereof. The kidney-tonifying, collateral-dredging and brain-nourishing paste is characterized by being prepared from the following crude drugs: radix rehmanniae preparata, rhizoma dioscoreae, fructus corni, poria cocos, cortex moutan, rhizoma alismatis, fructus lycii, semen cuscutae,ganoderma lucidum, fructus ligustri lucidi, herba ecliptae, fructus mori albae, mantidis ootheca, fructus alpiniae oxyphyllae, raw radix astragali seu hedysari, radix polygonati officinalis, lily bulb, semen persicae, safflower, red paeony root, rhizoma chuanxiong, radix bupleuri, fried fructus aurantii, radix achyranthis bidentatae, radix platycodonis, rhizoma anemones altaicae, prepared radix polygalae, rhizoma atractylodis, bighead atractylodes rhizome, semen nelumbinis, scorched fructus crataegi, medicated leaven, fried rice sprout, fried malt, pericarpium citri reticulatae, radix curcumae, radix clematidis, Chinese angelica root, processed rhizoma pinelliae, fructus liquidambaris, radix et rhizoma salviae miltiorrhizae, fructus amomi, American ginseng, syngnathus, hippocampus, tortoise-plastron glue, turtle shell glue, radix notoginseng, bulbus fritillariae cirrhosae, sugar and yellow rice wine. The kidney-tonifying, collateral-dredging and brain-nourishing paste is used for treating kidney insufficiency and essence deficiency, qi and blood deficiency, dizziness and tinnitus caused by stagnation of phlegm and blood stasis, insomnia and dreaminess, amnesia and somnolence, waistsoreness and limp legs, spermatorrhea and premature ejaculation, sterility infertility, hypertension, stroke sequelae, senile dementia, Parkinson's disease, paralysis agitans, multiple sclerosis andthe like, and also can be used for premature senility of middle-aged people or weakness of old people and the like.