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39 results about "Platycodi radix" patented technology

Fermented beverage capable of relieving fatigue and preparation method of fermented beverage

The invention provides a fermented beverage capable of relieving fatigue and a preparation method of the fermented beverage, and relates to the technical field of functional beverages, and the IPC classification number belongs to A23L2. The fermented beverage is prepared from a radix astragali fermentation extract, a radix platycodonis extract, L-arginine, taurine, inositol, caffeine, nicotinamide, vitamin B6, L-lysine hydrochloride, pyrroloquinoline quinone and auxiliary materials. The astragalus mongholicus fermentation extract can improve the ATP generation efficiency, reduce lactic acid accumulation after exercise, relieve damage of oxidative stress to muscle and nerve cells and reduce immunosuppression caused by fatigue; the platycodon grandiflorum extract has the effects of refreshing mind and restoring consciousness, improving cognitive function decline caused by central fatigue, enhancing capillary permeability and promoting removal of metabolic wastes. The radix astragali fermentation extract and the radix platycodonis extract are compounded to achieve a synergistic effect, so that the composition has an excellent anti-fatigue effect. Under the combined action of all the components, fatigue is relieved, energy is rapidly supplemented, and physical strength is recovered.
Owner:GUANGZHOU EASTROC BEVERAGE

Preparation method and application of ceramide-containing platycodon grandiflorum extract

The invention belongs to the field of plant extract processing, and particularly relates to a preparation method and application of a ceramide-containing platycodon grandiflorum extract. The preparation method comprises the following steps: adding crushed radix platycodonis rhizomes and leaves into 45% ethanol for soaking, ultrasonically treating a material-liquid mixture for 40 minutes, and taking residual radix platycodonis dregs as a raw material for preparing ceramide. The preparation method comprises the following steps: carrying out solid fermentation on a platycodon grandiflorum herb residue mixed strain S.paucimobilis for 72 hours, then extracting to obtain a ceramide crude product, and purifying through macroporous resin to obtain the ceramide-containing platycodon grandiflorum extract. The platycodon grandiflorum extract obtained by the method contains natural ceramide from a plant source, has no irritation to chick embryos, can be used as a cosmetic raw material, has soothing and repairing effects, and is beneficial to increasing the additional economic value of platycodon grandiflorum and promoting ecological environment protection.
Owner:YUNNAN SEEDSHARE DEV CO LTD

Extraction process and method for extracting platycodin D from platycodon grandiflorum

The invention relates to the technical field of medicinal material treatment equipment, in particular to an extraction process and method for extracting platycodin D. The extraction process comprises extraction equipment for extracting platycodin D of platycodon grandiflorum, the extraction equipment further comprises an ultrasonic extraction tank, and a plurality of ultrasonic oscillators are fixedly connected to the lower portion of the inner surface of the ultrasonic extraction tank. The left side of the upper end of the ultrasonic extraction tank is fixedly connected with a feeding port, the right side of the upper end of the ultrasonic extraction tank is fixedly connected with a water injection port, the middle of the upper end of the ultrasonic extraction tank is fixedly connected with a first motor, and the output end of the first motor penetrates through the upper end of the ultrasonic extraction tank and is fixedly connected with a stirring mechanism. According to the extraction process and method for extracting platycodin D from platycodon grandiflorum, the deslagging mechanism is arranged at the lower part of the ultrasonic extraction tank, and after the device is used, a second motor in the deslagging mechanism can be started to drive an auger blade to rotate, so that residues accumulated in the tank can be discharged outwards through the rotation of the auger blade; and internal cleaning of the device is more convenient.
Owner:ANHUI JIAOJIAN HEALTH TECHNOLOGY CO LTD

The application of the drug for preventing and treating deafness in the preparation of drugs for preventing and treating acute kidney injury caused by cisplatin

The application relates to an application of a drug for preventing and treating deafness in preparation of a drug for preventing and treating acute kidney injury caused by cisplatin, wherein the effective component of the drug for preventing and treating acute kidney injury caused by cisplatin is prepared from raw medicinal materials in the following weight percentage: 27-33% of ginseng, 16-20% of astragalus, 16-20% of pueraria, 11-13% of curcuma, 12-15% of platycodon, and 8-10% of licorice. The drug for preventing and treating acute kidney injury caused by cisplatin in the application can obviously reduce the creatinine and urea nitrogen levels, improve the morphological damage of kidney tissues, and has a remarkable effect on preventing and treating acute kidney injury caused by cisplatin.
Owner:GUANGDONG PHARMA UNIV

Detection method of infantile cough syrup

The invention belongs to the technical field of medicines, and particularly relates to an infantile cough relieving syrup detection method which comprises the following steps: identifying radix peucedani, platycodon grandiflorum, pericarpium citri reticulatae and cortex mori radicis in infantile cough relieving syrup by adopting a thin layer chromatography; and simultaneously detecting the fructus arctii and the radix scutellariae by adopting a high performance liquid chromatography. The detection method for the infantile cough relieving syrup has the advantages of being rapid in analysis, easy to operate, high in accuracy, wide in adaptability and the like, and establishment and overall evaluation of the quality standard of the infantile cough relieving syrup are facilitated.
Owner:CHENGDU BETTER DENUO PHARM CO LTD

Use of pgugt29 in synthesis of platycodin d3

The application discloses application of PgUGT29 in synthesis of kudou saponin D3. Specifically, the application includes cloning, codon optimization, protein expression and purification of the gene PgUGT29 and application of the enzyme activity of the protein. The nucleotide sequence of the kudou PgUGT gene is shown as SEQ ID NO. 1, the optimized nucleotide sequence is shown as SEQ ID NO. 2, and the encoded amino acid sequence is shown as SEQ ID NO. 3. The kudou PgUGT29 gene in the application has the function of specifically catalyzing kudou saponin D to generate kudou saponin D3, and can be used for generating kudou saponin D3, improving the quality of kudou and improving the pharmacological activity of kudou.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +2

Healthy energy strengthening and stasis removing formula for resisting non-small cell lung cancer and preparation method of healthy energy strengthening and stasis removing formula

The invention relates to a body resistance strengthening and stagnation eliminating prescription for resisting non-small cell lung cancer and a preparation method thereof. The body resistance strengthening and stagnation eliminating prescription is prepared from the following raw material medicines in parts by weight: 2-50g / part of radix fici simplicissimae, 2-50g / part of radix pseudostellariae, 2-50g / part of poria cocos, 2-50g / part of rhizoma atractylodis macrocephalae, 2-50g / part of radix scutellariae, 2-50g / part of oldenlandia diffusa, 2-50g / part of radix ranunculi ternati, 2-50g / part of polygonum cuspidatum, 2-50g / part of curcuma zedoary, 2-50g / part of oyster, 2-50g / part of platycodon grandiflorum, 2-50g / part of edible tulip and 2-50g / part of sculellaria barbata. Cell tests and construction of an NSCLC osimertinib-resistant animal model prove that the body resistance strengthening and stagnation eliminating prescription can regulate a tumor microenvironment (TME) and inhibit growth of osimertinib-resistant non-small cell lung cancer cells. In addition, the formula for strengthening the body resistance and removing stasis can also inhibit growth of common non-small cell lung cancer cells. Meanwhile, clinical observation finds that the body resistance strengthening and stasis removing prescription can improve symptoms such as insomnia, rash and diarrhea of patients with lung accumulation (lung cancer and pulmonary nodule), and improve the life quality of the patients.
Owner:SHENZHEN BAOAN DISTRICT TRADITIONAL CHINESE MEDICINE HOSPITAL

Rhinitis pill patch for treating rhinitis and preparation method thereof

The invention discloses a rhinitis pill patch for treating rhinitis and a preparation method thereof. The rhinitis pill patch is prepared from the following raw materials: codonopsis pilosula, honeysuckle, cimicifugae foetidae, astragalus membranaceus, houttuynia cordata, bighead atractylodes rhizome, radix bupleuri, almond, platycodon grandiflorum, fried divaricate saposhnikovia root, paniculate swallowwort root, biond magnolia flower, cassia twig, folium mori, rhizoma zingiberis, white paeony root, radix angelicae, semen lepidii, cocklebur fruit, chrysanthemum, fructus forsythiae, mint, scutellaria baicalensis, pig nail, spina gleditsiae, red paeony root and the like. The preparation method comprises the steps of drying, crushing and pelleting. The rhinitis pill patch is used for relieving symptoms such as nasal obstruction, rhinocnesmus, sneezing and clear nasal discharge, has the functions of tonifying lung and spleen, and ventilating lung and opening orifices, is administrated through the Shenque acupoint, has the clinical effective rate of 98%, is simple, convenient and efficient, is suitable for people of all ages, and is especially suitable for children.
Owner:丁长城

Electron beam irradiation sterilization and quality detection method for Platycodon grandiflorum

The invention discloses a platycodon electron beam irradiation sterilization and quality detection method, which belongs to the field of Chinese medicine sterilization and quality detection of Chinese medicine, and comprises the following steps: (1) establishing a fingerprint of platycodon; (2) sealing and packaging the platycodon in a packaging bag, and irradiating the packaged platycodon using a high-energy electron accelerator; (3) storing the irradiated platycodon at room temperature; (4) performing quality detection on the irradiated platycodon. The application can significantly reduce the number of microorganisms in platycodon; the test results show that after 360 days of storage, the number of microorganisms in the irradiated platycodon meets the requirements of the pharmacopoeia, and the sensory properties and physical and chemical indicators thereof are not significantly changed. At the same time, under the same chromatographic conditions, the application not only establishes the fingerprint of platycodon, but also simultaneously determines the content of platycodon saponin D in platycodon. The whole method is simple to operate and has both qualitative and quantitative functions. The application overcomes the singleness of the original quality detection method and has a high application value.
Owner:SOUTHWEAT UNIV OF SCI & TECH

Traditional Chinese medicine composition and application thereof

The invention discloses a traditional Chinese medicine composition and application thereof. The composition comprises 8-12 parts of agastache rugosus, 4-8 parts of fructus gleditsiae, 8-12 parts of radix angelicae, 8-12 parts of pericarpium citri reticulatae, 4-8 parts of mint, 4-8 parts of liquorice, 8-12 parts of platycodon grandiflorum, 4-8 parts of radix aucklandiae, 8-12 parts of radix saposhnikoviae, 4-8 parts of pinellia ternate, 0.1-0.5 part of realgar, 8-12 parts of radix ampelopsis, 8-12 parts of notopterygium root, 8-12 parts of radix bupleuri, 8-12 parts of scutellaria baicalensis, 4-8 parts of coptis chinensis, 8-12 parts of golden cypress, 8-12 parts of poria cocos, 8-12 parts of rhizoma alismatis, 8-12 parts of fructus aurantii, 8-12 parts of radix scrophulariae and 4-8 parts of The traditional Chinese medicine composition can be used for treating or preventing fever, respiratory tract diseases, digestive tract diseases or myocarditis caused by viruses, bacteria or fungi, and has the advantages of scientific formula and exact curative effect.
Owner:BEIJING CHANGJIDE HEALTH TECHNOLOGY CO LTD

Equipment for preparing depression-relieving and mind-tranquilizing ointment and preparation method thereof

The invention discloses a preparation method, and particularly relates to equipment for preparing paste for relieving depression and stabilizing mind and a preparation method of the paste for relieving depression and stabilizing mind. 8 parts of radix curcumae; 12 parts of salvia miltiorrhiza; 10 parts of Chinese angelica; 8 parts of ligusticum wallichii; 15 parts of radix paeoniae alba; 5 parts of liquorice; 7 parts of fructus aurantii; 6 parts of green tangerine peel; 6 parts of pericarpium citri reticulatae; 4 parts of radix scutellariae; 4 parts of moutan bark; 10 parts of hawthorn; and 8 parts of platycodon grandiflorum. The strategy of dosing in batches and decocting in sections ensures that all the medicinal materials release effective components at the most appropriate temperature and time, and the situation that volatile components are lost due to long-time high temperature is avoided, so that the overall medicine effect extraction rate is increased. The precise temperature control, vacuum concentration and time-phased dosing strategy effectively avoids the adverse effects of high temperature, overlong decoction and other process conditions on the active ingredients, so that the drug properties of the medicinal materials are fully retained and played in a balanced manner.
Owner:JINAN ZHANGQIU DISTRICT HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Quality detection method of bulbus fritillariae cirrhosae lung-heat-clearing syrup

The invention provides a quality detection method of bulbus fritillariae cirrhosae lung-heat-clearing syrup. According to the quality detection method, the contents of amygdalin, sipeimine, liquiritin and platycodin in the bulbus fritillariae cirrhosae lung-heat-clearing syrup are detected by adopting an HPLC-ELSD (High Performance Liquid Chromatography-Evaporative Light Scattering Detector) chromatography. According to the method disclosed by the invention, the contents of four components, namely amygdalin, sipeimine, liquiritin and platycodin D, in the bulbus fritillariae cirrhosae lung-heat-clearing syrup are determined by adopting an HPLC-ELSD method, so that the quality of the bulbus fritillariae cirrhosae lung-heat-clearing syrup can be relatively rapidly evaluated, and reference is expected to be provided for quality control of a preparation. According to the method, interference of strong ultraviolet absorption substances is effectively avoided, the research cost is reduced, the operation process is simplified, an economic and efficient analysis means is provided for determining the content of saponin compounds, and meanwhile, a reference is provided for formulating a quality control standard of the bulbus fritillariae cirrhosae lung-heat-clearing syrup.
Owner:FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE

Traditional chinese medicine composition and use thereof

PCT designated stageWO2026138383A1OfficinalPharmaceutical Aids
Provided are a traditional Chinese medicine composition and a method for preparing same. The composition is prepared from the following raw materials and optionally a pharmaceutically acceptable excipient. The raw materials include: Astragali Radix, Lonicerae Flos, Saposhnikoviae Radix, Cinnamomi Ramulus, Paeoniae Alba Radix, Forsythiae Fructus, Atractylodis Macrocephalae Rhizoma, Platycodonis Radix, Zingiberis Rhizoma, Jujubae Fructus, Citri Reticulatae Pericarpium, Isatidis Radix, and Glycyrrhizae Radix et Rhizoma. The composition can be used for preparing a medicament for treating common cold, viral infection, fever, inflammation, or cough, for relieving phlegm, for relieving pain, for immunoregulation, or for protecting influenza A close contacts.
Owner:BEIJING YILING PHARMA

Plumose thistle phosphoglucose isomerase gene PgGPI, product encoded by the gene and application

The application discloses a platycodon grandiflorum phosphoglucoisomerase gene PgGPI and an application of a product coded by the platycodon grandiflorum phosphoglucoisomerase gene PgGPI, and belongs to the technical field of platycodon grandiflorum genes. The platycodon grandiflorum phosphoglucoisomerase gene PgGPI is cloned from the platycodon grandiflorum, and a nucleotide sequence of the platycodon grandiflorum phosphoglucoisomerase gene PgGPI is shown as SEQ ID NO. 1. The PgGPI gene is successfully expressed in Escherichia coli, and it is verified through an enzymatic experiment that the PgGPI has catalytic activity and can effectively isomerize glucose-6-phosphate into fructose-6-phosphate, thereby laying a solid foundation for further exploring a biosynthesis mechanism of the platycodon grandiflorum polysaccharide. In addition, by means of the PgGPI gene and gene engineering technology, it is expected to significantly improve the content of the polysaccharide substance in the platycodon grandiflorum.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Antibacterial and antiviral formula for improving lung immunity

The invention discloses an antibacterial and antiviral formula for improving lung immunity, which is prepared from the following raw materials in parts by weight: 9-13 parts of honeysuckle, 9-13 parts of rhinacanthus nasutus, 9-13 parts of platycodon grandiflorum, 9-13 parts of houttuynia cordata, 9-13 parts of radix scrophulariae, 9-13 parts of mint, 9-13 parts of folium mori, 9-13 parts of divaricate saposhnikovia root, 9- 6-10 parts of rhinacanthus nasutus; 6-10 parts of platycodon grandiflorum; 6-10 parts of herba houttuyniae; 8-12 parts of radix scrophulariae; 5-9 parts of mint; 9-13 parts of folium mori; 8-12 parts of divaricate saposhnikovia root; 20 to 24 parts of corn; and 3-7 parts of licorice. The health-care formula provided by the invention is prepared by compatibility of medicinal and edible traditional Chinese medicinal materials, has the effects of relieving cough and reducing sputum, moistening dryness and tonifying qi, clearing away heat and toxic materials and the like, not only improves lung health, but also is easy to purchase.
Owner:TIANJIN CLOUD LADDER ENTERPRISE MANAGEMENT CONSULTING CO LTD

Medicated diet composition for treating heat cough, and preparation method therefor and use thereof

A medicated diet composition for treating a heat cough, prepared from the raw materials in the following parts by mass: 50-100 parts of kumquat, 30-50 parts of Eleocharis dulcis, 5-10 parts of Glehniae radix and 5-10 parts of Platycodonis radix. The medicated diet composition can improve the symptoms of a heat cough of a SARS-CoV-2 infection.
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE +1

Application of traditional chinese medicine composition in preparation of drugs for treating neuritis

A traditional Chinese medicine composition for treating neuritis. The traditional Chinese medicine composition is prepared mainly from Notopterygii Rhizoma et Radix, Angelicae Pubescentis Radix, Poria, Saposhnikoviae Radix, Schizonepetae Herba, Chuanxiong Rhizoma, Platycodonis Radix, Bupleuri Radix, Peucedani Radix, Aurantii Fructus, and Glycyrrhizae Radix et Rhizoma. The traditional Chinese medicine composition can significantly relieve facial paralysis, movement disorders, and other related symptoms of facial neuritis in a rat, remarkably improve expression of VEGFb, VEGFR1, and VEGFR2 proteins in postoperative side facial nerves of the rat, and promote recovery and regeneration of damaged rear axons.
Owner:SHANDONG NEW TIME PHARMA CO LTD

Packaging box (Platycodon pear juice)

InactiveCN309146322SMechanical engineeringPlatycodi radix
1. Name of the product of this design: Packaging box (Platycodon pear juice). 2. Purpose of this design product: used for packaging products. 3. The design key point of this appearance design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view.
Owner:ANHUI GUOYI PHARMACEUTICAL CO LTD

Platycodon grandiflorum phosphomannose isomerase gene PgPMI as well as encoded product and application thereof

PendingCN122071709ABacteriaMicroorganism based processesEscherichia coliGlycosyl-Phosphatidylinositol
The invention discloses a platycodon grandiflorum phosphomannose isomerase gene PgPMI as well as an encoded product and application thereof, and belongs to the technical field of platycodon grandiflorum genes. According to the invention, the platycodon grandiflorum phosphomannose isomerase gene PgPMI is cloned from platycodon grandiflorum, and the nucleotide sequence of the platycodon grandiflorum phosphomannose isomerase gene PgPMI is shown as SEQ ID NO. 1. According to the invention, the expression of the PgPMI gene in escherichia coli is successfully realized, and an enzymatic experiment verifies that the PgPMI has catalytic activity, so that mannose-6-phosphoric acid and fructose-6-phosphoric acid can be mutually converted, and a foundation is laid for revealing biosynthesis of platycodon grandiflorum polysaccharide. In addition, the platycodon grandiflorum phosphomannose isomerase can also be applied to biosynthesis pathways of plant ascorbic acid, cell walls, glycosylated proteins, lipoproteins, glycosyl phosphate inositol ankyrin and the like.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Pharmaceutical composition for resisting chronic heart failure as well as preparation method and application of pharmaceutical composition

The invention provides a pharmaceutical composition for resisting chronic heart failure as well as a preparation method and application thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix aconiti lateralis preparata, semen lepidii, poria cocos, rhizoma atractylodis macrocephalae, radix paeoniae alba, fresh ginger, rhizoma alismatis, peach kernels, flos carthami, radix salviae miltiorrhizae, radix angelicae sinensis, rhizoma chuanxiong, radix achyranthis bidentatae, radix bupleuri, fructus aurantii, radix platycodonis, radix astragali, fructus jujubae and radix glycyrrhizae preparata. The prepared pharmaceutical composition for resisting chronic heart failure is simple in preparation method and good in treatment effect, has very good effects of regulating vascular tension, myocardial contractility and heart remodeling, inhibits ferroptosis of myocardial cells so as to protect myocardial cells from being damaged and prevent heart failure, and is small in side effect, high in patient compliance and free of toxic and side effects. Wide application prospects are realized.
Owner:XIDIAN GRP HOSPITAL

Loquat syrup and preparation method thereof

The invention discloses loquat syrup and a preparation method thereof, and relates to the field of medicines.The preparation method comprises the steps that folium eriobotryae, radix stemonae and platycodon grandiflorum are subjected to percolation extraction with an ethanol solution, and fat-soluble components in the three kinds of medicinal materials such as triterpenic acid components in the folium eriobotryae, alkaloid components in the radix stemonae and saponin components in the platycodon grandiflorum can be effectively extracted; meanwhile, medicine residues obtained after percolation, pericarpium papaveris, cynanchum glaucescens and cortex mori radicis are decocted and extracted together with water, water-soluble components such as alkaloids, flavonoids, polysaccharides and amino acids in the medicine residues can be effectively extracted, and the preparation method has the advantages of being easy to operate and implement, high in preparation efficiency, good in stability and the like; the quality and the clinical treatment effect of the loquat syrup can be obviously improved.
Owner:YAAN THREE NINE PHARMA

Traditional Chinese medicine composition as well as preparation method and application thereof

The invention belongs to the field of medicine, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof. The invention relates to a preparation method of an anti-aging agent. Comprising the following components in parts by weight: 60-150 parts of astragalus membranaceus, 8-15 parts of angelica sinensis, 6-12 parts of radix paeoniae rubra, 8-12 parts of peach kernel, 6-10 parts of safflower, 6-12 parts of radix bupleuri, 10-20 parts of radices trichosanthis, 12-25 parts of salvia miltiorrhiza, 6-12 parts of ligusticum wallichii, 15-30 parts of radix rehmanniae recen, 8-15 parts of radix achyranthis bidentatae, 8-12 parts of fructus aurantii, 8-12 parts of platycodon grandiflorum, 5-10 parts of liquorice, 10-30 parts of folium mori, 8-15 parts of almond, 8-15 parts of scutellaria baicalensis, 10-30 parts of folium eriobotryae, 3-10 parts of raw rhubarb, 6-20 parts of bulbus fritillariae cirrhosae and 3-12 parts of pseudo-ginseng. Optionally, the composition also comprises 6-12 parts of lumbricus. Optionally, the composition further comprises 3-9 parts of ground beetles. Postoperative intracranial and pulmonary infection can be prevented, the pathological basis of nerve injury is improved, neural function recovery is promoted, and patient prognosis is improved.
Owner:BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV

Application of traditional Chinese medicine composition in preparation of medicine for preventing and / or treating cytokine storm

The traditional Chinese medicine composition is mainly prepared from herba schizonepetae, radix saposhnikoviae, rhizoma seu radix notopterygii, radix angelicae pubescentis, poria cocos, rhizoma chuanxiong, radix platycodonis, radix bupleuri, radix peucedani, fructus aurantii and radix glycyrrhizae, and the new application refers to application of the traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating cytokine storm. Research finds that the traditional Chinese medicine composition can rapidly and effectively restrain release of cytokines, and a safe and effective treatment medicine is provided for preventing and treating cytokine storm.
Owner:SHANDONG NEW TIME PHARMA CO LTD

Detection method of traditional Chinese medicine composition

The invention relates to a method for detecting a traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from ephedra, bitter apricot kernel, platycodon grandiflorum, radix peucedani, thunberg fritillary bulb, radix stemonae, radix glehniae, oroxylum indicum and liquorice, the method is characterized in that the detection comprises the step of carrying out UPLC-TQ-MS detection on a test solution of the traditional Chinese medicine composition, and the chromatographic conditions of the UPLC-TQ-MS detection comprise: the specification is 3.0 * 50 mm; an Agilent Eclipse Plus C18 chromatographic column with the size of 1.8 [mu] m is adopted; a mobile phase is an A (0.08% formic acid water (containing 0.0625% ammonium formate) solution)-B (acetonitrile) system.
Owner:JIANGSU KANION PHARMA CO LTD

External ointment for treating eczema and preparation method thereof

The invention relates to an external ointment for treating eczema and a preparation method thereof. Sinkiang lithospermum erythrorhizon, radix sophorae flavescentis and cortex phellodendri are used as monarch drugs. Sinkiang lithospermum erythrorhizon clears heat, cools blood, detoxifies and promotes eruption, radix sophorae flavescentis and cortex phellodendri clear heat, eliminate dampness, dispel wind and arrest itching, and directly act on the root of eczema damp-heat toxin. Salvia miltiorrhiza, radix rehmanniae, radix paeoniae rubra, cortex moutan and purslane are used as ministerial drugs. The radix rehmanniae, the radix paeoniae rubra and the cortex moutan are used for cooling blood and clearing heat, and the purslane is used for clearing away heat and toxic materials and assisting the monarch drug to enhance the effects of clearing heat and cooling blood, and dispersing blood stasis and relieving itching. Cynanchum paniculatum, radix saposhnikoviae, radix angelicae, platycodon grandiflorum, sanguisorba officinalis and cortex dictamni are used as adjuvant drugs. Radix cynanchi paniculati and divaricate saposhnikovia root dispel wind and arrest itching, radix angelicae dahuricae eliminates dampness and arrest itching, platycodon grandiflorum carries medicine and is transdermal, sanguisorba officinalis is used for cooling blood and astringing, cortex dictamni is used for clearing heat and eliminating dampness, and monarch and ministerial medicines are jointly assisted in A trace amount of dexamethasone is used for assisting rapid anti-inflammation, uncomfortable symptoms such as skin itch, papule and scabbing caused by eczema can be relieved, and instant pain of a patient can be rapidly relieved; skin barrier damage caused by eczema is improved, and normal physiological function recovery of skin is promoted.
Owner:芦婷婷

A Platycodin Glycosyltransferase PgGT1, Its Encoding Gene and Applications

ActiveCN116606830BTransferasesFermentationAmino acid sequence homologyGlycosyltransferase
The present invention discloses a platycodin glycosyltransferase PgGT1, its encoding gene and applications, and claims a platycodin PgGT1 protein, which is a protein as follows (a1) or (a2): (a1) a protein encoded by the amino acid sequence shown in SEQ ID NO.2; (a2) a protein derived from SEQ ID NO.2 with a homology of ≧95% to the amino acid sequence shown in SEQ ID NO.2 and related to the regulation of the biosynthesis of platycodin D3 and / or platycodin E. The platycodin PgGT1 protein provided by the present invention can catalyze the addition of one molecule of glucose to the substrate platycodin D to generate platycodin D3 within ten minutes, and further rapidly and completely convert it into platycodin E within 1 h, having high economic value and broad application prospects.
Owner:CHINA PHARM UNIV

Platycodon grandiflorum 1-deoxy-D-xylulose-5-phosphate reductoisomerase PgDXR1 gene and application thereof

The invention provides a platycodon grandiflorum 1-deoxy-D-xylulose-5-phosphate reductoisomerase PgDXR1 gene, the nucleotide sequence of the platycodon grandiflorum 1-deoxy-D-xylulose-5-phosphate reductoisomerase PgDXR1 gene is as shown in SEQ ID NO. 1, and the amino acid sequence of a corresponding code is as shown in SEQ ID NO. 2. The invention further provides a plant overexpression vector containing the PgDXR1 gene and a genetically engineered host cell containing the PgDXR1 gene. In addition, the invention also provides an application of the PgDXR1 gene in regulation and control of synthesis of plant triterpenoid saponin. The invention provides the platycodon grandiflorum PgDXR1 gene related to synthesis of the triterpenoid saponin of the platycodon grandiflorum for the first time, and an expression product of the gene can positively regulate synthesis of the triterpenoid saponin; the invention provides new evidence for perfecting the synthetic route of the plant triterpenoid saponin, has important theoretical and practical significance for improving the quality of traditional Chinese medicinal materials, and provides a new way for regulating and controlling the content of the triterpenoid saponin of platycodon grandiflorum by utilizing genetic engineering.
Owner:WEST ANHUI UNIV

Plant composition for treating nasal polyp and nasal gland hypertrophy and preparation method thereof

The invention relates to the technical field of nasal disease treatment, in particular to a plant composition for treating nasal polyp and nasal gland hypertrophy, which is prepared from the following raw material medicines in parts by mass: 10 to 15 parts of flos magnoliae, 8 to 12 parts of radix angelicae, 10 to 20 parts of radix scutellariae, 15 to 25 parts of honeysuckle flower, 10 to 18 parts of fructus forsythiae, 5 to 10 parts of radix platycodonis, 3 to 8 parts of herba menthae, 10 to 20 parts of herba houttuyniae and 5 to 12 parts of herba centipedae. And the following active extraction components in parts by weight: 1-3 parts of bromelain, 0.5-2 parts of quercetin, 0.5-1.5 parts of curcumin and 1-4 parts of a frankincense serrata serrata extract. Nasal cavity inflammation and tissue edema are effectively relieved through a combined effect, firstly, flos magnoliae and radix angelicae in the formula can dissipate wind-cold, dredge nasal orifices and directly improve the ventilation function of the nasal cavity, meanwhile, radix scutellariae, honeysuckle and other medicinal materials clear away damp-heat toxin in the body through the effects of clearing away heat and drying dampness, inflammatory response is inhibited from the source, and the effect is remarkable. By matching with modern active ingredients such as bromelain and curcumin, the release of inflammatory mediators can be further blocked, and the capillary permeability is reduced.
Owner:GENERAL HOSPITAL OF PLA

Application of traditional chinese medicine composition in preparation of drugs for treating neuritis

ActiveUS12779001B2Facial nervePharmaceutical Substances
A traditional Chinese medicine composition for treating neuritis. The traditional Chinese medicine composition is prepared mainly from Notopterygii rhizoma et radix, Angelicae pubescentis radix, Poria, Saposhnikoviae radix, Schizonepetae herba, Chuanxiong rhizoma, Platycodonis radix, Bupleuri radix, Peucedani radix, Aurantii fructus, and Glycyrrhizae radix et rhizoma. The traditional Chinese medicine composition can significantly relieve facial paralysis, movement disorders, and other related symptoms of facial neuritis in a rat, remarkably improve expression of VEGFb, VEGFR1, and VEGFR2 proteins in postoperative side facial nerves of the rat, and promote recovery and regeneration of damaged rear axons.
Owner:SHANDONG NEW TIME PHARMA CO LTD

Compound emblic leafflower fruit sore-throat relieving lozenge film-coated tablet for treating throat diseases and preparation method thereof

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a compound emblic leafflower fruit sore-throat relieving lozenge film-coated tablet for treating throat diseases and a preparation method thereof. The compound emblic leafflower fruit sore-throat relieving lozenge film-coated tablet for treating throat diseases comprises a tablet core and a film coating layer wrapping the tablet core, the tablet core comprises phyllanthus emblica dry paste powder, compound dry powder, menthol, borneol, corn starch, sucrose powder and hydroxypropyl methylcellulose; the compound dry powder is a water extract of a mixture of radix scrophulariae, platycodon grandiflorum and liquorice; the weight ratio of the corn starch to the sucrose powder to the hydroxypropyl methylcellulose is (0.5-15): (45-60): (0.5-8); the film coating layer comprises gelatin; the weight ratio of the gelatin to the hydroxypropyl methylcellulose is (0.5-8): (0.3-3). The compound emblic leafflower fruit sore-throat relieving lozenge film-coated tablet for treating throat diseases has good storage stability, and the appearance and palatability are improved.
Owner:GUANGZHOU BAIYUNSHAN QIXING PHARMA