18 results about "Platycodi radix" patented technology

The invention belongs to the technical field of medicines, and particularly relates to an infantile cough relieving syrup detection method which comprises the following steps: identifying radix peucedani, platycodon grandiflorum, pericarpium citri reticulatae and cortex mori radicis in infantile cough relieving syrup by adopting a thin layer chromatography; and simultaneously detecting the fructus arctii and the radix scutellariae by adopting a high performance liquid chromatography. The detection method for the infantile cough relieving syrup has the advantages of being rapid in analysis, easy to operate, high in accuracy, wide in adaptability and the like, and establishment and overall evaluation of the quality standard of the infantile cough relieving syrup are facilitated.

The application discloses application of PgUGT29 in synthesis of kudou saponin D3. Specifically, the application includes cloning, codon optimization, protein expression and purification of the gene PgUGT29 and application of the enzyme activity of the protein. The nucleotide sequence of the kudou PgUGT gene is shown as SEQ ID NO. 1, the optimized nucleotide sequence is shown as SEQ ID NO. 2, and the encoded amino acid sequence is shown as SEQ ID NO. 3. The kudou PgUGT29 gene in the application has the function of specifically catalyzing kudou saponin D to generate kudou saponin D3, and can be used for generating kudou saponin D3, improving the quality of kudou and improving the pharmacological activity of kudou.

The invention discloses a rhinitis pill patch for treating rhinitis and a preparation method thereof. The rhinitis pill patch is prepared from the following raw materials: codonopsis pilosula, honeysuckle, cimicifugae foetidae, astragalus membranaceus, houttuynia cordata, bighead atractylodes rhizome, radix bupleuri, almond, platycodon grandiflorum, fried divaricate saposhnikovia root, paniculate swallowwort root, biond magnolia flower, cassia twig, folium mori, rhizoma zingiberis, white paeony root, radix angelicae, semen lepidii, cocklebur fruit, chrysanthemum, fructus forsythiae, mint, scutellaria baicalensis, pig nail, spina gleditsiae, red paeony root and the like. The preparation method comprises the steps of drying, crushing and pelleting. The rhinitis pill patch is used for relieving symptoms such as nasal obstruction, rhinocnesmus, sneezing and clear nasal discharge, has the functions of tonifying lung and spleen, and ventilating lung and opening orifices, is administrated through the Shenque acupoint, has the clinical effective rate of 98%, is simple, convenient and efficient, is suitable for people of all ages, and is especially suitable for children.

The invention discloses a preparation method, and particularly relates to equipment for preparing paste for relieving depression and stabilizing mind and a preparation method of the paste for relieving depression and stabilizing mind. 8 parts of radix curcumae; 12 parts of salvia miltiorrhiza; 10 parts of Chinese angelica; 8 parts of ligusticum wallichii; 15 parts of radix paeoniae alba; 5 parts of liquorice; 7 parts of fructus aurantii; 6 parts of green tangerine peel; 6 parts of pericarpium citri reticulatae; 4 parts of radix scutellariae; 4 parts of moutan bark; 10 parts of hawthorn; and 8 parts of platycodon grandiflorum. The strategy of dosing in batches and decocting in sections ensures that all the medicinal materials release effective components at the most appropriate temperature and time, and the situation that volatile components are lost due to long-time high temperature is avoided, so that the overall medicine effect extraction rate is increased. The precise temperature control, vacuum concentration and time-phased dosing strategy effectively avoids the adverse effects of high temperature, overlong decoction and other process conditions on the active ingredients, so that the drug properties of the medicinal materials are fully retained and played in a balanced manner.

Provided are a traditional Chinese medicine composition and a method for preparing same. The composition is prepared from the following raw materials and optionally a pharmaceutically acceptable excipient. The raw materials include: Astragali Radix, Lonicerae Flos, Saposhnikoviae Radix, Cinnamomi Ramulus, Paeoniae Alba Radix, Forsythiae Fructus, Atractylodis Macrocephalae Rhizoma, Platycodonis Radix, Zingiberis Rhizoma, Jujubae Fructus, Citri Reticulatae Pericarpium, Isatidis Radix, and Glycyrrhizae Radix et Rhizoma. The composition can be used for preparing a medicament for treating common cold, viral infection, fever, inflammation, or cough, for relieving phlegm, for relieving pain, for immunoregulation, or for protecting influenza A close contacts.

The application discloses a platycodon grandiflorum phosphoglucoisomerase gene PgGPI and an application of a product coded by the platycodon grandiflorum phosphoglucoisomerase gene PgGPI, and belongs to the technical field of platycodon grandiflorum genes. The platycodon grandiflorum phosphoglucoisomerase gene PgGPI is cloned from the platycodon grandiflorum, and a nucleotide sequence of the platycodon grandiflorum phosphoglucoisomerase gene PgGPI is shown as SEQ ID NO. 1. The PgGPI gene is successfully expressed in Escherichia coli, and it is verified through an enzymatic experiment that the PgGPI has catalytic activity and can effectively isomerize glucose-6-phosphate into fructose-6-phosphate, thereby laying a solid foundation for further exploring a biosynthesis mechanism of the platycodon grandiflorum polysaccharide. In addition, by means of the PgGPI gene and gene engineering technology, it is expected to significantly improve the content of the polysaccharide substance in the platycodon grandiflorum.

The invention discloses an antibacterial and antiviral formula for improving lung immunity, which is prepared from the following raw materials in parts by weight: 9-13 parts of honeysuckle, 9-13 parts of rhinacanthus nasutus, 9-13 parts of platycodon grandiflorum, 9-13 parts of houttuynia cordata, 9-13 parts of radix scrophulariae, 9-13 parts of mint, 9-13 parts of folium mori, 9-13 parts of divaricate saposhnikovia root, 9- 6-10 parts of rhinacanthus nasutus; 6-10 parts of platycodon grandiflorum; 6-10 parts of herba houttuyniae; 8-12 parts of radix scrophulariae; 5-9 parts of mint; 9-13 parts of folium mori; 8-12 parts of divaricate saposhnikovia root; 20 to 24 parts of corn; and 3-7 parts of licorice. The health-care formula provided by the invention is prepared by compatibility of medicinal and edible traditional Chinese medicinal materials, has the effects of relieving cough and reducing sputum, moistening dryness and tonifying qi, clearing away heat and toxic materials and the like, not only improves lung health, but also is easy to purchase.

A medicated diet composition for treating a heat cough, prepared from the raw materials in the following parts by mass: 50-100 parts of kumquat, 30-50 parts of Eleocharis dulcis, 5-10 parts of Glehniae radix and 5-10 parts of Platycodonis radix. The medicated diet composition can improve the symptoms of a heat cough of a SARS-CoV-2 infection.

The invention discloses a platycodon grandiflorum phosphomannose isomerase gene PgPMI as well as an encoded product and application thereof, and belongs to the technical field of platycodon grandiflorum genes. According to the invention, the platycodon grandiflorum phosphomannose isomerase gene PgPMI is cloned from platycodon grandiflorum, and the nucleotide sequence of the platycodon grandiflorum phosphomannose isomerase gene PgPMI is shown as SEQ ID NO. 1. According to the invention, the expression of the PgPMI gene in escherichia coli is successfully realized, and an enzymatic experiment verifies that the PgPMI has catalytic activity, so that mannose-6-phosphoric acid and fructose-6-phosphoric acid can be mutually converted, and a foundation is laid for revealing biosynthesis of platycodon grandiflorum polysaccharide. In addition, the platycodon grandiflorum phosphomannose isomerase can also be applied to biosynthesis pathways of plant ascorbic acid, cell walls, glycosylated proteins, lipoproteins, glycosyl phosphate inositol ankyrin and the like.

The invention belongs to the field of medicine, and particularly relates to a traditional Chinese medicine composition and a preparation method and application thereof. The invention relates to a preparation method of an anti-aging agent. Comprising the following components in parts by weight: 60-150 parts of astragalus membranaceus, 8-15 parts of angelica sinensis, 6-12 parts of radix paeoniae rubra, 8-12 parts of peach kernel, 6-10 parts of safflower, 6-12 parts of radix bupleuri, 10-20 parts of radices trichosanthis, 12-25 parts of salvia miltiorrhiza, 6-12 parts of ligusticum wallichii, 15-30 parts of radix rehmanniae recen, 8-15 parts of radix achyranthis bidentatae, 8-12 parts of fructus aurantii, 8-12 parts of platycodon grandiflorum, 5-10 parts of liquorice, 10-30 parts of folium mori, 8-15 parts of almond, 8-15 parts of scutellaria baicalensis, 10-30 parts of folium eriobotryae, 3-10 parts of raw rhubarb, 6-20 parts of bulbus fritillariae cirrhosae and 3-12 parts of pseudo-ginseng. Optionally, the composition also comprises 6-12 parts of lumbricus. Optionally, the composition further comprises 3-9 parts of ground beetles. Postoperative intracranial and pulmonary infection can be prevented, the pathological basis of nerve injury is improved, neural function recovery is promoted, and patient prognosis is improved.

The invention relates to a method for detecting a traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from ephedra, bitter apricot kernel, platycodon grandiflorum, radix peucedani, thunberg fritillary bulb, radix stemonae, radix glehniae, oroxylum indicum and liquorice, the method is characterized in that the detection comprises the step of carrying out UPLC-TQ-MS detection on a test solution of the traditional Chinese medicine composition, and the chromatographic conditions of the UPLC-TQ-MS detection comprise: the specification is 3.0 * 50 mm; an Agilent Eclipse Plus C18 chromatographic column with the size of 1.8 [mu] m is adopted; a mobile phase is an A (0.08% formic acid water (containing 0.0625% ammonium formate) solution)-B (acetonitrile) system.

The invention relates to an external ointment for treating eczema and a preparation method thereof. Sinkiang lithospermum erythrorhizon, radix sophorae flavescentis and cortex phellodendri are used as monarch drugs. Sinkiang lithospermum erythrorhizon clears heat, cools blood, detoxifies and promotes eruption, radix sophorae flavescentis and cortex phellodendri clear heat, eliminate dampness, dispel wind and arrest itching, and directly act on the root of eczema damp-heat toxin. Salvia miltiorrhiza, radix rehmanniae, radix paeoniae rubra, cortex moutan and purslane are used as ministerial drugs. The radix rehmanniae, the radix paeoniae rubra and the cortex moutan are used for cooling blood and clearing heat, and the purslane is used for clearing away heat and toxic materials and assisting the monarch drug to enhance the effects of clearing heat and cooling blood, and dispersing blood stasis and relieving itching. Cynanchum paniculatum, radix saposhnikoviae, radix angelicae, platycodon grandiflorum, sanguisorba officinalis and cortex dictamni are used as adjuvant drugs. Radix cynanchi paniculati and divaricate saposhnikovia root dispel wind and arrest itching, radix angelicae dahuricae eliminates dampness and arrest itching, platycodon grandiflorum carries medicine and is transdermal, sanguisorba officinalis is used for cooling blood and astringing, cortex dictamni is used for clearing heat and eliminating dampness, and monarch and ministerial medicines are jointly assisted in A trace amount of dexamethasone is used for assisting rapid anti-inflammation, uncomfortable symptoms such as skin itch, papule and scabbing caused by eczema can be relieved, and instant pain of a patient can be rapidly relieved; skin barrier damage caused by eczema is improved, and normal physiological function recovery of skin is promoted.

The invention relates to the technical field of nasal disease treatment, in particular to a plant composition for treating nasal polyp and nasal gland hypertrophy, which is prepared from the following raw material medicines in parts by mass: 10 to 15 parts of flos magnoliae, 8 to 12 parts of radix angelicae, 10 to 20 parts of radix scutellariae, 15 to 25 parts of honeysuckle flower, 10 to 18 parts of fructus forsythiae, 5 to 10 parts of radix platycodonis, 3 to 8 parts of herba menthae, 10 to 20 parts of herba houttuyniae and 5 to 12 parts of herba centipedae. And the following active extraction components in parts by weight: 1-3 parts of bromelain, 0.5-2 parts of quercetin, 0.5-1.5 parts of curcumin and 1-4 parts of a frankincense serrata serrata extract. Nasal cavity inflammation and tissue edema are effectively relieved through a combined effect, firstly, flos magnoliae and radix angelicae in the formula can dissipate wind-cold, dredge nasal orifices and directly improve the ventilation function of the nasal cavity, meanwhile, radix scutellariae, honeysuckle and other medicinal materials clear away damp-heat toxin in the body through the effects of clearing away heat and drying dampness, inflammatory response is inhibited from the source, and the effect is remarkable. By matching with modern active ingredients such as bromelain and curcumin, the release of inflammatory mediators can be further blocked, and the capillary permeability is reduced.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a compound emblic leafflower fruit sore-throat relieving lozenge film-coated tablet for treating throat diseases and a preparation method thereof. The compound emblic leafflower fruit sore-throat relieving lozenge film-coated tablet for treating throat diseases comprises a tablet core and a film coating layer wrapping the tablet core, the tablet core comprises phyllanthus emblica dry paste powder, compound dry powder, menthol, borneol, corn starch, sucrose powder and hydroxypropyl methylcellulose; the compound dry powder is a water extract of a mixture of radix scrophulariae, platycodon grandiflorum and liquorice; the weight ratio of the corn starch to the sucrose powder to the hydroxypropyl methylcellulose is (0.5-15): (45-60): (0.5-8); the film coating layer comprises gelatin; the weight ratio of the gelatin to the hydroxypropyl methylcellulose is (0.5-8): (0.3-3). The compound emblic leafflower fruit sore-throat relieving lozenge film-coated tablet for treating throat diseases has good storage stability, and the appearance and palatability are improved.

The invention belongs to the technical field of medicines, and in particular relates to an application of apiose-platycodin D3 (Deapiose-platycodin D3, the molecular formula of which is C58H94O29, the molecular weight of which is 1255.36 and the CAS number of which is 67884-05-3) in preparation of a medicine for treating gastrointestinal tumors. Through cell proliferation experiments and clone formation experiments, it is verified for the first time that apiose platycodin D3 can effectively inhibit growth of human esophageal cancer, colorectal cancer and gastric cancer cells. The invention provides a new candidate drug and basis for clinical treatment and prevention of gastrointestinal tumors.

Disclosed are a traditional Chinese medicine composition for clearing heat, detoxifying, relieving sore throat, and reducing swelling, and a preparation method therefor, and use thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-20 parts of Houttuyniae Herba, 8-15 parts of Astragali Radix, 8-15 parts of Andrographis Herba, 8-15 parts of Scrophulariae Radix, 8-15 parts of Platycodonis Radix, 8-15 parts of Archidendri Folium, 2-6 parts of Lonicerae Japonicae Flos, 2-6 parts of Bupleuri Radix, 2-6 parts of Belamcandae Rhizoma, 2-6 parts of Peucedani Radix, 1-4 parts of Trollii Flos, and 0.1-0.6 parts of Calculus Bovis Factitius. The effect of the traditional Chinese medicine composition in treating acute pharyngitis and fever abatement is superior to that of each comparative example.

The application discloses a method for regulating the germination and growth of platycodon grandiflorum by allelopathy between medicinal materials and application thereof, and uses water extraction of traditional Chinese medicinal materials to carry out allelopathy treatment on platycodon grandiflorum seeds to regulate the germination and growth of the platycodon grandiflorum, wherein the traditional Chinese medicinal materials are any one of radix cyathulae, radix saposhnikoviae and radix adnati; the water extraction of traditional Chinese medicinal materials is any one of water extraction of radix cyathulae, water extraction of radix saposhnikoviae and water extraction of radix adnati; the concentration of the water extraction of radix cyathulae is 10-20 mg / ml; the concentration of the water extraction of radix saposhnikoviae is 10-30 mg / ml; and the concentration of the water extraction of radix adnati is 20-30 mg / ml; the application takes radix adnati, radix cyathulae and radix saposhnikoviae as research objects, studies the allelopathy of the water extraction of the three kinds of traditional Chinese medicinal materials on the germination and seedling growth of the platycodon grandiflorum, and selects the most suitable traditional Chinese medicinal material for intercropping with the platycodon grandiflorum and a treatment method before intercropping, thereby laying a foundation for the selection of the platycodon grandiflorum and other intercropped medicinal materials in the future.

The application provides a fermented beverage for relieving fatigue and a preparation method thereof, and relates to the technical field of functional beverages, and belongs to the technical field of A23L2. The fermented beverage comprises a radix astragali fermentation extract, a platycodon grandiflorum extract, L-arginine, taurine, inositol, caffeine, nicotinamide, vitamin B6, L-lysine hydrochloride, pyrroloquinoline quinone and excipients. The radix astragali fermentation extract can improve ATP generation efficiency, reduce post-exercise lactic acid accumulation, reduce the damage of oxidative stress to muscle and nerve cells, and reduce immune suppression caused by fatigue; the platycodon grandiflorum extract can refresh the mind, improve the cognitive function decline caused by central fatigue, enhance capillary permeability, and promote the removal of metabolic waste. The radix astragali fermentation extract and the platycodon grandiflorum extract have excellent anti-fatigue effect. Under the combined action of various components, fatigue is relieved, energy is quickly supplemented, and physical strength is recovered.