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Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves

a cell therapy and tissue regeneration technology, applied in the field of improving cell therapy in patients, can solve the problems of impaired overall recruitment of stem/progenitor cells in patients with cardiovascular risk factors, and achieve the effects of reducing home comfort, increasing expression of chemoattractants, and reducing the ability to re-inject drugs

Inactive Publication Date: 2006-11-02
DORNIER MEDTECH SYST GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The present invention provides a therapeutic tool to improve the recruitment of stem and progenitor cells in patients undergoing cell therapy. This is achieved by using shock waves as a therapeutic tool to enhance the expression of chemoattractant and pro-angiogenic factors in the targeted tissue, which will improve the recruitment of systemically infused stem and progenitor cells. Combining the application of shock waves and stem cells and / or progenitor cells can enhance the therapeutic effect for cardiovascular and neurological diseases.

Problems solved by technology

Since the expression of chemoattractant factors in chronically injured tissue is markedly reduced as compared to acute injury, the overall recruitment of stem / progenitor cells in patients with cardiovascular risk factors is impaired.

Method used

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  • Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves
  • Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves
  • Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves

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examples

[0066] 1. Materials for Preparing Endothelial Progenitor Cells from Peripheral Blood

[0067] As the starting material for preparing endothelial progenitor cells, peripheral blood was freshly drawn and collected in heparin monovettes (10 ml).

[0068] The following materials were used in the examples described below.

[0069] Dulbecco's Phosphate Buffered Saline without calcium and magnesium (Cat. No. H-15-002) was used for suspension of the cells for injection. PAA was purchased from Laboratories GmbH (Pasching, Austria). EGM Bullet Kit (EBM medium) (Cat. No. CC-3124) and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine-labeled acetylated low-density lipoprotein (Dil-Ac-LDL) (Cat. No. #4003) was obtained from CellSystems (St. Katharinen, Germany). Fetal Bovine Serum (Cat. No. 10270-106) was obtained form Invitrogen GmbH (Karlsruhe, Germany). Biocoll Separating Solution, Density: 1.077 (Cat. No. L6115) was purchased from Biochrom AG (Berlin, Germany). Human fibronectin, 1 mg / ml (Cat...

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Abstract

Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and / or applying to the patient a therapeutically effective amount of stem cells and / or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient's heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.

Description

RELATED PATENT APPLICATION [0001] This application claims priority under 35 U.S.C. § 119 to U.S. Provisional Patent Application No. 60 / 636,204 filed Dec. 15, 2004 and entitled “Methods for Improving Cell Therapy and Tissue Regeneration in Patients with Cardiovascular and Neurological Diseases by Means of Shockwaves.” The subject matter of the above-identified priority application is hereby fully incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention relates to methods for improving cell therapy in a patient. More specifically, the present invention relates to methods for improving cell therapy in patient who is suffering from a cardiovascular or a neurological disease by using shock waves as a therapeutic tool for targeting the recruitment of stem cells and / or progenitor cells to a tissue of the patient. BACKGROUND OF THE INVENTION [0003] Stem and progenitor cells derived from the bone marrow may play a role in ongoing endothelial repair (Kalka et al., ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K48/00A61H1/00C12N15/09A61K35/44
CPCA61B17/22004A61B2017/00247A61B2018/00392A61H23/008A61K38/1866A61K38/195A61K35/44A61K2300/00A61P21/00A61P25/00A61P25/04A61P43/00A61P9/00A61P9/10
Inventor LUTZ, ANDREASEIZENHOFER, HARALDZEIHER, ANDREAS MICHAELDIMMELER, STEFANIEHEESCHEN, CHRISTOPHERAICHER, ALEXANDRA
Owner DORNIER MEDTECH SYST GMBH
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