Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy

A technology of cells and myocardium, applied in the field of tissue regeneration of ischemic cardiomyopathy
CN100366257CInactive Publication Date: 2008-02-06THE CLEVELAND CLINIC FOUND
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE CLEVELAND CLINIC FOUND
Publication Date
2008-02-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a method of treating the infarcted myocardial tissue, including the concentration of SDF-1 protein in the infarcted tissue. The concentration of stem cells in the peripheral blood of the infarcted tissue is also increased. When the concentration of SDF-1 protein in the infarcted tissue is increased, the number of stem cells in the peripheral blood is also increased at the same time.
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Description

field of invention

[0001] The invention relates to a method for tissue regeneration of ischemic cardiomyopathy, in particular to a method for treating ischemic cardiomyopathy after myocardial infarction for a long time (that is, multiple weeks). Background of the invention

[0002] Acute myocardial infarction (MI) remains the leading cause of morbidity and death in Western societies. Although recent therapeutic advances have been directed primarily at restoring perfusion to arteries associated with early infarcts, a "ceiling" of benefit exists, Topol, E.J. Lancet 357, 1905-1914 (2001). Patients with acute myocardial infarction (MI) essentially eventually develop congestive heart failure, mostly due to left ventricular (LV) remodeling, a process that involves the heart muscle becoming thinned, dilated, reduced in function, and eventually dead (CHF). Robbins, M.A. & O'Connell, J.B., pp.3-13 (Lippincott-Raven, Philadelphia, 1998). Pfeffer, J.M., Peffer, M.A., Fletcher, P.J. &...

Claims

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