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Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy

A technology of cells and myocardium, applied in the field of tissue regeneration of ischemic cardiomyopathy

Inactive Publication Date: 2008-02-06
THE CLEVELAND CLINIC FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A "ceiling" of benefit exists despite recent therapeutic advances directed primarily at restoring perfusion to arteries associated with early infarcts, Topol, E.J. Lancet 357, 1905-1914 (2001)

Method used

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  • Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy
  • Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy
  • Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy

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Embodiment

[0146] The present invention is further illustrated by the following specific examples. The examples given are for illustrative purposes only and are not intended to limit the scope or content of the invention in any way.

[0147] Effect of G-CSF on stem cell mobilization after 8 weeks of MI

[0148] In order to determine whether G-CSF-induced stem cell mobilization can induce myocardial regeneration in rats using the established model of ischemic cardiomyopathy, rats 8 weeks after MI were randomly assigned to receive recombinant human G-CSF (125 μg / kg / day, 5 days, intraperitoneal injection) group or saline group. Five days after initiation of G-CSF treatment, blood samples were obtained to demonstrate bone marrow stimulation, and the G-CSF group exhibited three-fold higher leukemia counts (37.3±5.3 cells / μl) compared to the saline group (11.8±4.0 cells / μl). Administration of 5-bromo-2'-deoxyuridine BrdU for 14 days started on the last day of G-CSF administration to label...

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Abstract

The present invention discloses a method of treating the infarcted myocardial tissue, including the concentration of SDF-1 protein in the infarcted tissue. The concentration of stem cells in the peripheral blood of the infarcted tissue is also increased. When the concentration of SDF-1 protein in the infarcted tissue is increased, the number of stem cells in the peripheral blood is also increased at the same time.

Description

field of invention [0001] The invention relates to a method for tissue regeneration of ischemic cardiomyopathy, in particular to a method for treating ischemic cardiomyopathy after myocardial infarction for a long time (that is, multiple weeks). Background of the invention [0002] Acute myocardial infarction (MI) remains the leading cause of morbidity and death in Western societies. Although recent therapeutic advances have been directed primarily at restoring perfusion to arteries associated with early infarcts, a "ceiling" of benefit exists, Topol, E.J. Lancet 357, 1905-1914 (2001). Patients with acute myocardial infarction (MI) essentially eventually develop congestive heart failure, mostly due to left ventricular (LV) remodeling, a process that involves the heart muscle becoming thinned, dilated, reduced in function, and eventually dead (CHF). Robbins, M.A. & O'Connell, J.B., pp.3-13 (Lippincott-Raven, Philadelphia, 1998). Pfeffer, J.M., Peffer, M.A., Fletcher, P.J. &...

Claims

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Application Information

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IPC IPC(8): A61K31/70A61K48/00A61K45/00A01N63/00C12N15/63C12N5/00C12N5/08A61P9/00A61P9/10C12N5/10
Inventor 马克·S·佩恩阿尔曼·T·阿斯卡里马修·凯德罗夫斯基
Owner THE CLEVELAND CLINIC FOUND
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