Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A bioactive scaffold for repairing the endometrium and enhancing fertility

A bioactive, collagen scaffold technology, applied in prosthetics, medical science, etc., can solve problems such as difficulty in restoring endometrial physiological functions and easy re-adhesion

Active Publication Date: 2021-11-30
ZHEJIANG UNIV
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hysteroscopic surgery to remove fibrous scars can restore the shape of the uterine cavity, it is often difficult to restore the physiological function of the endometrium
Moderate and severe intrauterine adhesions are very easy to re-adhesion after surgery, and the rate of post-operative re-adhesion is as high as 62.5%. There is still no effective method to prevent post-operative re-adhesion, resulting in a postoperative pregnancy rate of only 22.5% to 33.3%.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A bioactive scaffold for repairing the endometrium and enhancing fertility
  • A bioactive scaffold for repairing the endometrium and enhancing fertility
  • A bioactive scaffold for repairing the endometrium and enhancing fertility

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] (a) Preparation method of SDF-1α sustained-release particles with recruitment function

[0023] The SDF-1α sustained-release particles are formed by electrostatic complexing of negatively charged sulfonated chitosan, slightly positively charged SDF-1α and positively charged polylysine.

[0024] Sulfonated chitosan is prepared with chitosan as the base material and chlorosulfonic acid as the sulfonated reagent. First, 9 g of chitosan, 15 mL of dichloroacetic acid and 150 mL of formamide were thoroughly mixed in a beaker to fully swell the chitosan. After that, 150 mL of anhydrous DMF was placed in a 500 mL three-necked flask, stirred in an ice bath, and 30 mL of chlorosulfonic acid was slowly added dropwise thereto. After that, the fully swollen chitosan was added to the three-necked flask, and the reaction was carried out at 60° C. for 2 hours. After the reaction, a small amount of deionized water was added to neutralize chlorosulfonic acid, the precipitate was centri...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a bioactive scaffold for repairing endometrium and improving fertility. The scaffold includes a base and contained bioactive factors, and recruits and captures endogenous stem cells through the bioactive factors. Stem cells are pluripotent and play an immune regulatory role in wounds, which can effectively promote endometrial repair and significantly increase fertility. Aiming at the problems of intrauterine adhesions and reduced fertility rate caused by hysteroscopic surgery, the present invention adopts the homing method of endogenous stem cells integrating recruitment and capture to repair the damaged endometrium, avoiding traditional repair Safety hazards arising from the use of exogenous cells in materials. The raw materials used in the invention have good biocompatibility, simple preparation process, no exogenous cells, and high biological safety.

Description

technical field [0001] The invention relates to the field of tissue engineering scaffolds, in particular to a biologically active scaffold for repairing endometrium and improving fertility. Background technique [0002] Intrauterine adhesions are the second leading cause of secondary infertility in women, mainly caused by trauma, infection, etc. Endometrial damage is accompanied by regeneration and repair obstacles, endometrial fibrosis, and ultimately leads to intrauterine adhesions and endometrial atrophy. Endometrial fibrosis, as the main pathological feature of intrauterine adhesions, not only forms fibrous scars, leading to abnormal uterine cavity morphology, leading to infertility or miscarriage, but also aggravates the vicious circle of aplastic and fibrosis caused by ischemia and hypoxia. Although hysteroscopic surgery to remove fibrous scars can restore the shape of the uterine cavity, it is often difficult to restore the physiological function of the endometrium. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24A61L27/22A61L27/20
CPCA61L27/20A61L27/227A61L27/24C08L5/08
Inventor 马列张松英郑晓闻辛廖冰
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com