27 results about "Dichloroacetic acid" patented technology

The present invention provides a method for efficiently producing a nucleic acid oligomer. Specifically, the present invention provides a method for producing a nucleic acid oligomer represented by Formula (2), the method including a step of reacting a nucleic acid oligomer represented by Formula (1) with a dichloroacetic acid solution having a molar ratio of formaldehyde to dichloroacetic acid (formaldehyde mol / dichloroacetic acid mol) of 90×10−6 or less:wherein symbols have the meanings given in the description;wherein symbols have the meanings given in the description.

The application relates to a polyaryletherketone resin, a preparation method thereof and application thereof in functional membranes, and belongs to the technical field of functional polymer materials. First, an aromatic monomer 4,4'-((9-(6-(4-tritylphenoxy)hexyl)-9H-carbazole-3,6-diyl)bis(diphenylmethylene))diphenol (monomer 1) containing a dense benzene ring and a flexible side group is prepared; then, through a nucleophilic substitution reaction catalyzed by K2CO3, a polyaryletherketone precursor polymer containing a Schiff base is prepared by taking 1,1-bis(4-fluorophenyl)-N-phenylmethane imine, 4,4'-dihydroxydiphenyl ketone and the monomer 1 as raw materials; after the polyaryletherketone precursor polymer is sulfonated by concentrated sulfuric acid, a polyaryletherketone resin containing sulfonic acid groups is prepared; after the polyaryletherketone resin is dissolved in dichloroacetic acid, a polyaryletherketone ion exchange functional membrane is prepared by adopting a flow extension method, and the membrane has the advantages of excellent oxidation resistance stability, good dimensional stability and solution processing property and the like.

The invention belongs to the technical field of acyclic compounds, and particularly relates to a method for preparing chloroacetic acid by hydrogenation reduction of dichloroacetic acid, which comprises the following steps: A1, adding a chlorination liquid containing dichloroacetic acid into a raw material storage tank, mixing with hydrogen, and heating to obtain a mixed material; a2, conveying the mixed material into a hydrogenation reactor loaded with a composite metal modified catalyst for reaction to obtain chloroacetic acid liquid and mixed gas; and A3, conveying the mixed gas to a stripping tower, condensing the mixed gas through a condenser to obtain hydrogen chloride gas and condensate, and conveying the condensate to the hydrogenation reactor again for recycling. According to the method disclosed by the invention, a byproduct, namely the chlorination liquid, generated in a chlorination reaction in a chloroacetic acid production process is used as a reaction raw material, dichloroacetic acid and trichloroacetic acid in the chlorination liquid can be effectively reduced into chloroacetic acid, and other substances in the chlorination liquid cannot be influenced.

The present invention provides a production method for purified dichloroacetic acid and an efficient production method for nucleic acid molecules using same. Specifically, the present invention provides: a production method for purified dichloroacetic acid in which the molar ratio of formaldehyde to dichloroacetic acid is 81×10-5 or lower and the molar ratio of dichloroacetic anhydride to dichloroacetic acid is 20×10-5 or lower, wherein dichloroacetic acid having a formaldehyde and / or dichloroacetic anhydride content higher than the aforementioned ratios is brought into contact with at least one compound having a lower boiling point than dichloroacetic acid selected from the group consisting of aliphatic alcohols, aliphatic amines, and water, and a fraction including an aprotic inert solvent having a boiling point lower than that of dichloroacetic acid is distilled from the produced mixed liquid in the presence of the solvent; and a production method for nucleic acid molecules in which the purified dichloroacetic acid is used as a deprotection agent.

The invention discloses polyaryletherketone resin, a preparation method and application of the polyaryletherketone resin in a functional film, and belongs to the technical field of functional polymer materials. The preparation method comprises the following steps: firstly, preparing an aromatic monomer 4, 4 '-((9-(6-(4-triphenylmethyl phenoxy) hexyl)-9H-carbazole-3, 6-diyl) bis (diphenylmethylene)) diphenol (monomer 1) of a dense benzene ring containing a flexible side group, then taking 1, 1-bis (4-fluorophenyl)-N-phenylmethane imine, 4, 4'-dihydroxydiphenylketone and the monomer 1 as raw materials, and carrying out a nucleophilic substitution reaction catalyzed by K2CO3, so as to obtain the high-molecular polymer. A polyaryletherketone precursor polymer containing Schiff base is prepared; a polyaryletherketone precursor polymer is sulfonated with concentrated sulfuric acid, polyaryletherketone resin containing sulfonic acid groups is prepared, the polyaryletherketone resin is dissolved in dichloroacetic acid, a film is laid through a casting method, the polyaryletherketone ion exchange functional membrane is prepared, and the membrane has the advantages of being excellent in anti-oxidation stability, good in size stability, good in solution processability and the like.

The utility model discloses a system for recycling chloroacetic acid by dechlorinating dichloroacetic acid through photocatalysis, which relates to the technical field of chloroacetic acid synthesis equipment and comprises a collecting tank I used for collecting mother liquor containing dichloroacetic acid during preparation of chloroacetic acid, and the collecting tank I is sequentially connected with a plurality of stages of condensers and a filter I through pipelines. A filtrate outlet I of the filter I is sequentially connected with a storage tank, a photocatalytic reaction kettle, a plurality of stages of condensers and a filter II; a filtrate outlet II of the filter II is connected with the storage tank through a reflux pipeline; stirring mechanisms are arranged in the collecting tank I and the photocatalytic reaction kettle, an ultraviolet visible light lamp is mounted in the photocatalytic reaction kettle, a material inlet of the photocatalytic reaction kettle is connected with a mother liquor supply pipeline, a water supply pipeline, a catalyst supply pipeline and a hydrogen supply pipeline, and the collecting tank I is connected with a nitrogen pipeline. The yield of chloroacetic acid prepared by an acetic anhydride catalysis method is improved, the generation of waste liquid is reduced, and the treatment cost of wastewater is reduced.

This invention relates to the field of dichloroacetic acid preparation technology, specifically a method for preparing high-purity dichloroacetic acid. The method uses anhydrous dichloroacetic acid alkyl ester or anhydrous dichloroacetyl chloride as a single raw material. The method includes: adding deionized water to a corrosion-resistant reactor, starting stirring and cooling to 10-30°C, adding the single raw material and an acidic catalyst, reacting at 40-80°C for 1-8 hours, and then refining through multi-stage separation to obtain high-purity dichloroacetic acid. The anhydrous dichloroacetic acid alkyl ester is selected from methyl dichloroacetate, ethyl dichloroacetate, propyl dichloroacetate, or isopropyl dichloroacetate. The acidic catalyst is a ZrO₂-TiO₂ supported acid solid catalyst or a complex liquid organic acid catalyst.

The invention relates to the field of macromolecules, and discloses a method for refining polyetherketoneketone and a polyetherketoneketone refined product. The method comprises the following steps: (1) treating a polyetherketoneketone complex by adopting a pretreatment agent; (2) the polyether ketone ketone crude product and a mixed chain supporting solution are mixed and washed, a first product is obtained, the mixed chain supporting solution comprises a main chain supporting agent and a cosolvent, the main chain supporting agent comprises one or more selected from parachlorophenol, trifluoroacetic acid, difluoroacetic acid, dichloroacetic acid and chloroacetic acid, the cosolvent comprises one or more selected from N, N-dimethylformamide and dimethyl sulfoxide, and the main chain supporting agent comprises one or more selected from dichlorophenol, trifluoroacetic acid, difluoroacetic acid, dichloroacetic acid and chloroacetic acid. The solvent is one or more of water, N-methyl pyrrolidone and N-methyl formamide; (3) adding a mixed aqueous solution into the first product to remove at least part of metal ions to obtain a second product; and (4) washing the second product for multiple times by using an organic solvent, and washing and drying to obtain the refined polyether ketone ketone. The content of aluminum ions in the polyetherketoneketone prepared by the method is low.

The invention provides a method for simultaneously detecting dichloroacetic acid and trichloroacetic acid in urine, and belongs to the technical field of analysis detection and occupational health / environmental health. According to the method disclosed by the invention, a synergistic pretreatment strategy of acidic sample loading, WAX / reversed-phase mixed mode solid-phase extraction, water / low-proportion organic phase step-by-step leaching and ammonia-water-containing organic phase elution is adopted; a technical route of protein precipitation, acidification pH regulation, purification and enrichment by adopting WAX / reversed-phase mixed mode solid-phase extraction on a 96-well plate and stable isotope internal standard isotope dilution LC-MS / MS quantification is adopted, the method can effectively reduce the matrix effect and realize high-throughput analysis in a high-salinity urine matrix, the quantitation limits of DCEA and TCAA are not higher than 0.30 g / L and 0.20 g / L respectively, and the method has the advantages that the method is simple and convenient to operate, and the method is suitable for large-scale popularization and application. The method is suitable for biological monitoring and risk assessment of occupational and environmental low-level exposure crowds.

The invention relates to a preparation method of fatty acid amide propyl betaine, and belongs to the technical field of surfactants. The preparation method provided by the invention comprises the following steps: S1, adding N, N-dimethyl propane diamine into an initial raw material, and carrying out heating reflux reaction to obtain fatty acid amide propyl dimethylamine; the initial raw materials comprise at least one of fatty acid and derivatives thereof; s2, adding water, monochloroacetic acid and a sodium hydroxide aqueous solution into fatty acid amide propyl dimethylamine, heating and carrying out quaternization reaction to obtain a crude product; s3, hydrolyzing the crude product under the conditions that the temperature is 70 to 100 DEG C and the pressure is 0.1 to 0.5 MPa, so as to obtain the fatty acid amide propyl betaine. According to the preparation method provided by the invention, other impurities do not need to be introduced for post-treatment, the prepared fatty acid amide propyl betaine can effectively hydrolyze residual monochloroacetic acid and dichloroacetic acid, by-products are reduced, the product safety is remarkably improved, and the fatty acid amide propyl betaine has a relatively high application value.

Topical formulations comprising peroxyacids prepared in situ from trichloroacetic acid, dichloroacetic acid, monochloroacetic acid or acetic acid and hydrogen peroxide are useful for promoting hair growth and for preventing hair loss.

The present disclosure refers to therapeutic combinations and pharmaceutical compositions comprising glycolysis inhibitors / modulators and prenyltransferase inhibitors for treating brain tumors. In particular, the disclosure describes therapeutic combinations and pharmaceutical compositions of dichloroacetate (DCA) and perillyl alcohol (POH) useful for treating brain cancers such as glioblastoma multiforme (GBM). Additionally, the disclosure provides methods for treating GBM and other forms of brain cancer using the same.

This invention relates to the field of biopharmaceutical technology, specifically to the application of dichloroacetate in the preparation of drugs for preventing high-altitude pulmonary edema. This invention is the first to propose and verify the application of dichloroacetate in preventing high-altitude pulmonary edema. By administering dichloroacetate to mice via drinking water three days in advance as a preventative measure, the degree of pulmonary edema was reduced, providing new drug selection and experimental evidence for the prevention and treatment of altitude sickness.

The present application belongs to the field of microbial technology, and relates to a high-efficiency dichloroacetic acid degrading Pseudomonas aeruginosa and application thereof, the high-efficiency dichloroacetic acid degrading Pseudomonas aeruginosa is named SJTX, and the preservation number is CGMCC No. 36706. The Pseudomonas aeruginosa SJTX in the present application can grow by using dichloroacetic acid as a sole carbon source, can efficiently degrade dichloroacetic acid, and the degradation rates of the Pseudomonas aeruginosa on 10 mg / L, 50 mg / L and 100 mg / L dichloroacetic acid within 24 hours are 45.8%, 42.4% and 24.4% respectively, and the Pseudomonas aeruginosa has good adaptability to high salt and heavy metals, and is suitable for effectively removing and bioremediating dichloroacetic acid pollutants in water bodies, soil and other environments. The strain of the present application has good comprehensive performance in the degradation efficiency of dichloroacetic acid and environmental tolerance compared with the dichloroacetic acid degrading strains found.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a method for purifying a crude chloroacetic acid product. The method comprises the following steps: S1, impregnating activated carbon with chloropalladic acid to prepare a catalyst precursor; the preparation method comprises the following steps: blending a catalyst precursor, a dispersing agent, a reducing agent, poly (N-vinyl caprolactam) and (S, S)-(+)-N, N '-bis (3, 5-di-tert-butyl salicylidene)-1, 2-cyclohexanediamine, carrying out a reduction reaction to prepare a palladium-carbon catalyst, and passivating to prepare a passivated palladium-carbon catalyst; s2, the heated crude chloroacetic acid product and hydrogen are introduced into a micro-interface generator to be mixed, then hydrogenation reaction is carried out under the action of a passivated palladium-carbon catalyst, gas-liquid separation and rectification are carried out after the reaction is completed, and the chloroacetic acid product is prepared. By improving the problems of insufficient selectivity and conversion rate of dichloroacetic acid impurities in the chloroacetic acid crude product purified by the existing palladium-carbon catalyst, the content of the dichloroacetic acid impurities in the chloroacetic acid crude product after catalytic hydrogenation is effectively reduced.

The present disclosure refers to therapeutic combinations and pharmaceutical compositions comprising glycolysis inhibitors / modulators and prenyltransferase inhibitors for treating brain tumors. In particular, the disclosure describes therapeutic combinations and pharmaceutical compositions of dichloroacetate (DCA) and perillyl alcohol (POH) useful for treating brain cancers such as glioblastoma multiforme (GBM). Additionally, the disclosure provides methods for treating GBM and other forms of brain cancer using the same.

Topical formulations containing peroxyacids prepared in situ from trichloroacetic acid, dichloroacetic acid, monochloroacetic acid, or acetic acid and hydrogen peroxide are useful for promoting hair growth and preventing hair loss.

The present invention relates to an ionic compound, a pharmaceutical composition for treating cancer comprising the ionic compound, and method for preparing the ionic compound and the pharmaceutical composition. More specifically, it relates to a pharmaceutical composition for treating cancer: which comprises an ionic compound in which two different compounds, each different from the other, selected from ascorbic acid, dichloroacetic acid and lactate are combined with one metal ion; has better therapeutic effect by overlapping and complex disturbances of cancer cell metabolism because different compounds are simultaneously uptake into cancer cells and each acts through different mechanisms on cancer cells, compared to the conventional anticancer drugs focusing on one specific mutation or cancer cell growth signal; and can more effectively inhibit the proliferation, invasion and metastasis of cancer cells because it is less susceptible to drug.

A composition comprising dichloroacetic acid and glyoxylic acid, wherein the content of glyoxylic acid is below 1000 ppm, and a method for preparing and using the composition. A method for preparing the composition, which comprises mixing a dichloroacetic acid raw material having a glyoxylic acid content of more than 1000 ppm with a glyoxylic acid capturing reagent, and a method for preparing oligonucleotides, which comprises using the composition. It has been found that glyoxylic acid is an impurity in commercially available DCA products, which can cause failure in oligonucleotide synthesis. Ion chromatography can be used to detect glyoxylic acid in dichloroacetic acid and accurately determine its concentration.

The application discloses a doped photocatalytic reduction catalyst and a preparation method and application thereof, relates to the technical field of catalyst materials, and specifically discloses a doped photocatalytic reduction catalyst, which comprises the following raw materials in percentage by mass: tetrabutyl titanate 10-20%; a nickel source 4-8%; a cadmium source 1-2%; an ethanol aqueous solvent 40-60%; concentrated hydrochloric acid 1-10%; and diatomite 10-30%. The tetrabutyl titanate, the nickel source and the cadmium source account for 5-30% of the total amount of the raw materials, the amount ratio of the tetrabutyl titanate, the nickel source and the cadmium source is 1:0.1-0.3:0.02-0.06, and the amount ratio of ethanol and water in the ethanol aqueous solvent is 1-5:1. The obtained reduction catalyst can be used in a process for generating chloroacetic acid by adopting a dichloroacetic acid dechlorination method, so that the process can be carried out under normal pressure, the catalytic reaction condition is mild, the conversion rate of dichloroacetic acid is high, and the process is suitable for popularization and application to industrialization and large-scale production.

The invention relates to the technical field of chemical synthesis, and discloses a chloracetyl chitosan oligosaccharide derivative and a preparation method and application thereof.Monochloroacetic acid (MCAA), dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) with disinfection and sterilization capabilities are grafted to chitosan oligosaccharide to generate the novel chloracetyl chitosan oligosaccharide derivative; chitosan oligosaccharide is a macromolecule containing-NH2 and multiple-OH and has good biological activity and biocompatibility, the macromolecule formed after acylation of three kinds of chloroacetic acid and chitosan oligosaccharide is added with disinfection and sterilization capacity, meanwhile, the low-toxicity characteristic and biocompatibility of chitosan oligosaccharide are reserved, and chitosan oligosaccharide becomes a novel excellent bactericide.

This invention pertains to the preparation technology of chemical intermediates and aims to provide a method for the continuous production of dichloroacetic acid and dichloroacetyl chloride. The method includes: continuously feeding sulfuric acid, water, and tetrachloroethylene into a continuous flow reactor, heating to carry out a continuous reaction; discharging gas from the top of the continuous flow reactor, and overflowing liquid from the top of the reactor; separating the gas and liquid phases to obtain the products dichloroacetic acid and / or dichloroacetyl chloride; controlling the ratio of dichloroacetic acid and dichloroacetyl chloride by adjusting the feed rates of sulfuric acid, water, and tetrachloroethylene. This invention utilizes a continuous flow reactor to allow the raw materials to contact in a continuous gas-liquid turbulent flow, ensuring thorough mixing, promoting the reaction, and improving the mass transfer effect between reactants. Compared with existing technologies, this invention significantly improves reaction efficiency, significantly reduces equipment costs, and enhances operational safety, enabling continuous production.

The application discloses a hydrophilic convertible ternary eutectic solvent and a preparation method and application thereof, and belongs to the technical field of plant active substance extraction. The hydrophilic convertible ternary eutectic solvent is prepared by taking tetrabutylammonium chloride, dichloroacetic acid and ethylene glycol as raw materials. The eutectic solvent can be used as an extraction reagent to extract polyphenol components in sorghum bran. Compared with traditional extraction reagents, 70% ethanol and 70% methanol, the ternary eutectic solvent greatly improves the yield of polyphenols in sorghum bran.

The present invention provides a production method for purified dichloroacetic acid and an efficient production method for a nucleic acid molecule using the same. Specifically, the present invention provides a production method for purified dichloroacetic acid having a molar ratio of formaldehyde to dichloroacetic acid of 81 × 10-5 or less and a molar ratio of dichloroacetic anhydride to dichloroacetic acid of 20 × 10-5 or less, the method including: bringing dichloroacetic acid having both or one of formaldehyde content and dichloroacetic anhydride content exceeding the ratio(s), into contact with at least one compound having a boiling point lower than that of dichloroacetic acid selected from the group consisting of aliphatic alcohols, aliphatic amines, and water, and, in the coexistence of an aprotic inert solvent having a boiling point lower than that of dichloroacetic acid, distilling off a fraction containing the solvent from the resulting mixed liquid, and a production method for a nucleic acid molecule using the purified dichloroacetic acid as a deprotecting agent.