7 results about "Dichloroacetic acid" patented technology

The present invention provides a production method for purified dichloroacetic acid and an efficient production method for nucleic acid molecules using same. Specifically, the present invention provides: a production method for purified dichloroacetic acid in which the molar ratio of formaldehyde to dichloroacetic acid is 81×10-5 or lower and the molar ratio of dichloroacetic anhydride to dichloroacetic acid is 20×10-5 or lower, wherein dichloroacetic acid having a formaldehyde and / or dichloroacetic anhydride content higher than the aforementioned ratios is brought into contact with at least one compound having a lower boiling point than dichloroacetic acid selected from the group consisting of aliphatic alcohols, aliphatic amines, and water, and a fraction including an aprotic inert solvent having a boiling point lower than that of dichloroacetic acid is distilled from the produced mixed liquid in the presence of the solvent; and a production method for nucleic acid molecules in which the purified dichloroacetic acid is used as a deprotection agent.

This invention relates to the field of dichloroacetic acid preparation technology, specifically a method for preparing high-purity dichloroacetic acid. The method uses anhydrous dichloroacetic acid alkyl ester or anhydrous dichloroacetyl chloride as a single raw material. The method includes: adding deionized water to a corrosion-resistant reactor, starting stirring and cooling to 10-30°C, adding the single raw material and an acidic catalyst, reacting at 40-80°C for 1-8 hours, and then refining through multi-stage separation to obtain high-purity dichloroacetic acid. The anhydrous dichloroacetic acid alkyl ester is selected from methyl dichloroacetate, ethyl dichloroacetate, propyl dichloroacetate, or isopropyl dichloroacetate. The acidic catalyst is a ZrO₂-TiO₂ supported acid solid catalyst or a complex liquid organic acid catalyst.

Topical formulations comprising peroxyacids prepared in situ from trichloroacetic acid, dichloroacetic acid, monochloroacetic acid or acetic acid and hydrogen peroxide are useful for promoting hair growth and for preventing hair loss.

This invention relates to the field of biopharmaceutical technology, specifically to the application of dichloroacetate in the preparation of drugs for preventing high-altitude pulmonary edema. This invention is the first to propose and verify the application of dichloroacetate in preventing high-altitude pulmonary edema. By administering dichloroacetate to mice via drinking water three days in advance as a preventative measure, the degree of pulmonary edema was reduced, providing new drug selection and experimental evidence for the prevention and treatment of altitude sickness.

The present application belongs to the field of microbial technology, and relates to a high-efficiency dichloroacetic acid degrading Pseudomonas aeruginosa and application thereof, the high-efficiency dichloroacetic acid degrading Pseudomonas aeruginosa is named SJTX, and the preservation number is CGMCC No. 36706. The Pseudomonas aeruginosa SJTX in the present application can grow by using dichloroacetic acid as a sole carbon source, can efficiently degrade dichloroacetic acid, and the degradation rates of the Pseudomonas aeruginosa on 10 mg / L, 50 mg / L and 100 mg / L dichloroacetic acid within 24 hours are 45.8%, 42.4% and 24.4% respectively, and the Pseudomonas aeruginosa has good adaptability to high salt and heavy metals, and is suitable for effectively removing and bioremediating dichloroacetic acid pollutants in water bodies, soil and other environments. The strain of the present application has good comprehensive performance in the degradation efficiency of dichloroacetic acid and environmental tolerance compared with the dichloroacetic acid degrading strains found.

This invention pertains to the preparation technology of chemical intermediates and aims to provide a method for the continuous production of dichloroacetic acid and dichloroacetyl chloride. The method includes: continuously feeding sulfuric acid, water, and tetrachloroethylene into a continuous flow reactor, heating to carry out a continuous reaction; discharging gas from the top of the continuous flow reactor, and overflowing liquid from the top of the reactor; separating the gas and liquid phases to obtain the products dichloroacetic acid and / or dichloroacetyl chloride; controlling the ratio of dichloroacetic acid and dichloroacetyl chloride by adjusting the feed rates of sulfuric acid, water, and tetrachloroethylene. This invention utilizes a continuous flow reactor to allow the raw materials to contact in a continuous gas-liquid turbulent flow, ensuring thorough mixing, promoting the reaction, and improving the mass transfer effect between reactants. Compared with existing technologies, this invention significantly improves reaction efficiency, significantly reduces equipment costs, and enhances operational safety, enabling continuous production.