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Process for preparation of alpha-ketoglutaric acid

一种酮戊二酸、制备工艺的技术，应用在α-酮戊二酸的制备工艺领域，能够解决α-酮戊二酸制备方法复杂、生产成本增加、不能满足市场的需求等问题

Inactive Publication Date: 2012-07-18
张国基
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the traditional preparation method of α-ketoglutaric acid is very complex, time-consuming and costly, and is not suitable for industrial production
Especially the traditional method will use a large amount of organic solvents in the reaction, which makes the production cost increase, the production time is long, it is not suitable for mass production, and cannot meet the needs of the market

Method used

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  • Process for preparation of alpha-ketoglutaric acid
  • Process for preparation of alpha-ketoglutaric acid
  • Process for preparation of alpha-ketoglutaric acid

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Embodiment Construction

[0030] figure 1 and figure 2 It is a process step for preparing α-ketoglutaric acid in the present invention;

[0031] (a) Reaction of equimolar methyl dichloroacetate and methyl acrylate in the presence of sodium methoxide to obtain dimethyl 2,2-dichloroglutarate;

[0032] (b) Reaction of dimethyl 2,2-dichloroglutarate with alkali solution to obtain crude α-ketoglutarate aqueous solution;

[0033] (c) Purifying the crude α-ketoglutaric acid aqueous solution to obtain a refined α-ketoglutaric acid aqueous solution;

[0034] (d) adding water to adjust the concentration of the purified α-ketoglutarate aqueous solution;

[0035] The preparation of dimethyl 2,2-dichloroglutarate is further described as follows:

[0036] In the reactor, add equimolar methyl dichloroacetate and methyl acrylate, start stirring, and control the reaction temperature at 40°C to 50°C. Then slowly add a concentration of 30% sodium methoxide solution into the reactor, the weight of sodium methoxide i...

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Abstract

A process for preparation of [alpha]-ketoglutaric acid, comprising the steps of: (a) reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain dimethyl 2,2-dichloroglutarate; (b) reacting the dimethyl 2,2-dichloroglutarate from step (a) with hydroxide solution to obtain crude [alpha]-ketoglutaratic acid aqueous solution; (c) purifying the crude [alpha]-ketoglutaratic acid aqueous solution to obtain purified [alpha]-ketoglutaratic acid aqueous solution; and (d) adjusting a concentration of the purified [alpha]-ketoglutaratic acid aqueous solution by adding water, thereby a yield of the purified [alpha]-ketoglutaratic acid aqueous solution is approximately 75%. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.

Description

technical field [0001] The invention belongs to a preparation method of a pharmaceutical preparation containing two carboxyl active ingredients, especially avoiding the use of a large amount of organic solvents in the production process, obtaining a high product yield and low cost for mass production of α-ketone Preparation process of glutaric acid. Background technique [0002] α-Ketoglutarate is an important biomolecule, one of the important intermediates in the tricarboxylic acid cycle, a nitrogen transporter and a symbiotic substance in molecular oxidation. It plays an important role in the metabolism of microbial cells and is also an important precursor for the synthesis of various amino acids and proteins. It can be used as a nutrition enhancer, as a component of sports nutrition drinks, as an organic intermediate, as a biochemical reagent, as a supporting reagent for measuring liver function, as a physical enhancement supplement, etc. In addition, α-ketoglutarate ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/347C07C51/02
CPCC07C51/43C07C67/347C07C51/412C07C51/47C07C277/08C07C51/02C07C51/41C07C279/02C07C69/63C07C59/347
Inventor 张国基
Owner 张国基
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