61 results about "Chloral hydrate" patented technology

The invention relates to the technical field of medical dressings, in particular to an itching-relieving hydrogel dressing and a preparation method thereof. The itching-relieving hydrogel dressing comprises cortex phellodendri extract, radix scutellariae extract, radix sophorae flavescentis extract, fructus cnidii extract, cortex dictamni extract, mint, glycerol, carbomer, chloral hydrate, epsilon-polylysine, camphor, borneol, propylene glycol and purified water. The itching-relieving hydrogel dressing has the advantages that by being prepared from pure traditional Chinese medicines except for adjuvants, the itching-relieving hydrogel dressing is little in irritation, free from toxic or side effect, safe to use, good in permeability and treatment effect and quick in action and can be used for relieving symptoms such as skin and mucosa itching caused by cicatrices formed after burn, scald, operations and vagina or various other wounds.

The invention relates to a process for synthesizing 1-[(2,4-dichlorobenzene) methyl]-1H-indazole-3-carboxyl acid which consists of, using phenylhydrazine as starting raw material, producing beta-acetylphenylhydrazine through reaction with glacial acetic acid, reacting with hydrated chloral and hydroxylamine hydrochloride, obtaining N-acetamido-isonitro-acetanilide, preparing 1H-indazole-3-carboxylic acid under the condition of concentrated sulfuric acid, finally subjecting 1H-indazole-3-carboxylic acid with 2,4-dichlorin benzyl chloride.

The invention relates to a chloral hydrate permeabilization flaking method in microscopic identification of TC, which can effectively solve the problem of easy control, high efficiency and safety of chloral hydrate permeabilization. The method comprises the following steps: adding water in chloral hydrate for dissolving to obtain a chloral hydrate solution with mass concentration of 30-50%; adding 0.1-0.5g of traditional Chinese medicinal material powder into 2ml of chloral hydrate solution with mass concentration of 30-50% to prepare a mixture; filling the mixture into a container, preheating to 100-110 DEG C, then heating to 125-135 DEG C for 4-8 minutes, realizing permeabilization of the mixture; dropping the 1-2 drops of permeabilized mixture on a slide glass, adding 1-2 drops of dilute glycerin, uniformly mixing the traditional Chinese medicinal material powder on the slide glass, covering a coverslip, using an absorbent paper to remove overflowed liquid, and keeping the clean coverslip and slide glass. The flaking method can be effectively used for chloral hydrate permeabilization, and has the advantages of energy saving, safety, high efficiency, controllable performance, wide application and environmental protection, is especially suitable for teaching and scientific research, has strong utility value, and is great innovation of chloral hydrate permeabilization flaking method.

The invention provides a method for detecting a chloral hydrate raw material and chloral hydrate suppository related substances. The method comprises the steps of carrying out derivatization reactionand then carrying out GC-MS detection. The method is good in specificity and high in sensitivity, the stability and repeatability of the method are good, the analyzing efficiency is high, various impurities of chloral hydrate suppository can be qualified and quantified sensitively and accurately, therefore, the quality of the chloral hydrate suppository is evaluated objectively, comprehensively and accurately, and the method plays an important significance on control over the quality of the chloral hydrate suppository and guaranteeing the clinical effects.

The invention discloses an oral sedative for children. The oral sedative comprises the following components: simple syrup, a chloral hydrate solution with the mass concentration of 10%-20%, and a glucose solution, containing sodium citrate, with the mass concentration of 5%-10% according to the volume proportion of the (1-2):2:1, wherein the mass concentration of the glucose solution dissolving sodium citrate is 5%-10%; the main simple syrup component is the simple syrup of cane sugar, and the mixed oral sedative is a weak alkaline solution with the pH value of 7-8. According to the sedative formula of the application, (1) the taste of the conventional chloral hydrate is improved, and the conflict reaction when the sedative is taken by an infant patient is reduced; (2) the effect-taking time of the oral chloral hydrate sedative is shortened, so that the sedative can be absorbed by small intestines relatively easily, the bioavailability is improved, the stimulation on gastrointestinal tracts is reduced, and nausea and vomiting are reduced.

The invention discloses a method for preparing a single-cell suspension of aortic cells of a mouse. The method is characterized by specifically comprising the following steps of firstly, preparing 1 ml of an enzyme mixed solution, the surviving healthy wild mouse, an operating table of which the whole tabletop is a flat ice surface and a plurality of instruments; and then, performing intraperitoneal injection anesthesia on the prepared wild mouse by 200-500 microliters of chloral hydrate until the mouse is dead, immediately performing perfusion flushing on blood vessels of the wild mouse by 20ml of a phosphate buffer salt solution, performing overall disinfection on the dead wild mouse by alcohol with the volume fraction of 75%, performing thoracotomy andlaparotomy after disinfection is completed, and exposing the heart and the aorta. The whole operation process is completed on the operating table. Preparation of a single-cell suspension of vascular tissues of the mouse by using a shearing and mixed enzyme combined digestion process is simple, convenient and feasible, more immune cells exist, and an effective tissue single-cell suspension preparation method is provided for research of vascular immune cells.

The invention discloses stable chloral hydrate syrup as well as a preparation method, a quality control method and application thereof, belongs to the technical field of medicines, and solves the problems that chloral hydrate is poor in stability, harsh in storage condition and short in validity period and needs to be diluted during use in the prior art. The stable chloral hydrate syrup comprises chloral hydrate, cane sugar and water, the mass volume concentration of chloral hydrate is 10%, and the pH value of the chloral hydrate syrup is 2.3-3.0. The chloral hydrate syrup disclosed by the invention also comprises glycerol. The chloral hydrate syrup disclosed by the invention adopts the specification that the concentration of chloral hydrate used clinically is 10%, does not need to be newly prepared when in use, and is accurate in dosage, safe, controllable and stable in property.

The invention relates to refrigerator deodorants. The refrigerator deodorants comprise, by weight, 3-8 parts of sodium carbonate, 2-4 parts of chloral hydrate, 4-7 parts of potassium permanganate, 3-5 parts of ethyl alcohol, 1-3 parts of single ricinoleic acid glyceride, 2-6 parts of sodium chloride, 1-5 parts of ten-polyglycerol palmitate, 2-4 parts of glycerinum, 0.6-2 parts of lactic acid and 25 parts of water. The refrigerator deodorants have the beneficial effects of being colourless and tasteless, free of corrosion, environment-friendly and the like; meanwhile, peculiar smells in a refrigerator can be effectively removed; in addition, a certain bactericidal effect is achieved.

The invention relates to a method for detecting the content of impurities in a drug, in particular to a method for determining the content of halogenated acid in chloral hydrate or a preparation thereof through gas chromatography.

The invention relates to a manufacturing method of a single and isometric gastric ulcer model induced by acetic acid in a rat. The method comprises procedures as follows: the rat is fasting but drinks freely for 24 hours; the chloral hydrate of 10 percent (0.3nl/100g weight) is used for anesthetizing the rat by muscle administration; lodophor is used for sterilizing the abdomen skin of the rat; a cut is made on the side wall of the abdomen and a stomach is pulled out slightly; the nipper with an annular front end (with the inner diameter of 9mm) clamps a corpus ventriculi part 3mm away from a pyloric part; after a distal stomach-antrum is penetrated, 0.81ml of the mineral oil and the acetic acid solution of 160 percent of 0.02ml ( with the total volume of 0.2ml) are injected into a lumen; after 45 seconds, the mixed solution of acetic acid and the mineral oil is absorbed from stomach; afterwards, the physiological saline of 2ml is injected into a gastral cavity for flushing and is drained off after 1min; and at last, the stomach is put back and the abdomen is sewed up. After an operation, the rat is carried out usual care. The method is easy to be handled and can make a single round ulcer with the inner diameter of 9mm. The area and the depth of the ulcer can be controlled. In addition, the problem of adhesion can be solved; the ulcer is extremely similar with the human ulcer in pathological features and healing mechanism; and the ulcer model is very sensitive to various anti-ulcer drugs.

Methods for detecting chloral hydrate in dichloroacetic acid are described.

An industrialization preparation method for 4-fluoroisatin is disclosed by the invention, and comprises: (a) dissolving chloral hydrate and sodium sulfate in water, heating to 30 DEG C-35 DEG C, then successively adding m-fluoroaniline, concentrated hydrochloric acid and an aqueous solution of hydroxylamine hydrochloride, heating to 80 DEG C-90 DEG C for continually reaction, after a complete reaction, air-pump filtering and washing the filter cake with water, and obtaining the intermediate; and (b) heating concentrated sulfuric acid to 50 DEG C-60 DEG C, successively adding TEBBE reagent and the intermediate obtained in step (a), then continually heating to 80 DEG C-85 DEG C and reacting, after a complete reaction, cooling and precipitating an orange red precipitate, and therefore obtaining the 4-fluoroisatin product. The invention also discloses the corresponding 4-fluoroisatin product. The industrialization preparation method can help to obtain the product with a simple process, a high yield and low cost, and is convenient to control quality and applicable in industrialization production in a large scale.

The invention relates to a production method of isatin. The production method comprises the following steps: (1) aniline hydrochloride (or containing part of un-salinized aniline) produced by reactionof aniline and hydrochloric acid is subjected to oximation reaction with chloral hydrate, hydroxylamine hydrochloride, water and sodium sulfate decahydrate or sodium sulfate in an acid medium, oximido acetanilide is obtained in the range of the ratio determined by the action mechanism of sodium sulfate, part of solid-phase sodium sulfate is retained in the system in the initial stage of the reaction, and the ratio of aniline (mol)/water (kg) can be increased; (2) in the closed-loop reaction, the reaction time is prolonged in exchange for low reaction temperature and low sulfuric acid concentration in order to improve the reaction safety and increase the yield of isatin. Compared with typical processes, the method has the advantages that the reaction safety is improved, the yield of isatinis increased, unit consumption and production cost can also be reduced, the utilization rate of equipment is increased, and the amount of produced waste water is reduced. According to the process, noobvious amplification effect is found by tests in thousands of moles.

The invention relates to a sample pretreatment method for detecting the content of chloral hydrate in a health-care product and a detection method of the chloral hydrate. The sample pretreatment method for detecting the content of chloral hydrate in the health care product comprises the following steps: taking a proper amount of sample, adding an acid solution, heating, and decomposing chloral hydrate to generate HCl and HCOOH gases; and absorbing the generated gas with water to obtain a solution to be detected. According to the method, chloral hydrate can be subjected to a hydrolysis reaction under acidic and heating conditions and generate hydrogen chloride and formic acid with high volatility, then the hydrogen chloride and the formic acid are separated by combining a gas-liquid separation technology, and the content of chloral hydrate in the health care product is determined by adopting an analysis technology for detecting chloride ions or formic acid. Compared with the prior art, the sample pretreatment method for detecting the content of chloral hydrate in the health care product and the detection method of the sample pretreatment method have the advantages that matrix interference can be effectively eliminated, the sample pretreatment time is shortened, the detection and analysis process of chloral hydrate in the health care product is greatly simplified, the steps are simple, and the sensitivity is high.

The invention provides a method for determining the content of chloroalkane in chloral hydrate or a preparation thereof by gas chromatography, which comprises the following steps of 1, precisely weighing a chloroalkane reference substance, and dissolving the chloroalkane reference substance in an organic solvent to obtain a reference substance solution, 2, dissolving or diluting a to-be-detected sample chloral hydrate or a preparation thereof with water or an inorganic salt aqueous solution optionally, adding an organic solvent for extraction, and taking an organic layer as a test solution, and 3, respectively detecting the reference substance solution and the test solution through gas chromatography, and calculating the content of the chloralkane.

The invention provides a calming spray used before live pig slaughtering, relating to the technical field of live pig slaughtering. The calming spray comprises the following raw materials: 80-100 parts of chloral hydrate solution, 60-70 parts of sodium citrate, 60-80 parts of glucose solution, 5-7 parts of sucrose, 6-8 parts of simple syrup, 3-5 parts of vermilion powder, 6-8 parts of magnetite powder, 7-9 parts of euphorbia royleana, 6-8 parts of seed of wild jujube, 3-5 parts of amber essential oil, 2-4 parts of polygala root, 3-5 parts of tuckahoe, 4-6 parts of cortex albiziae and 60-80 parts of water. The calming spray has the beneficial effects that the adopted raw materials are rich and cheap, the preparation process is simple and convenient, the raw material ratio is reasonable, the raw materials are easy to obtain, the used raw materials are pollution-free, and non-toxic chemical agents and Chinese patent medicines are reasonably compounded, thereby ensuring the lasting and safe drug effect, avoiding the strong body influence to live pigs, being harmless to the meat quality of the live pigs, and ensuring the emotional stability of the live pigs.

The invention relates to a garden seed sterilization mildew-proof treating agent. The treating agent is composed of the following ingredients, by weight, 28-32 parts of corn starch, 30-34 parts of red peppers, 26-30 parts of anhydrite mine, 30-34 parts of fly ash, 26-30 parts of clinoptilolite, 30-34 parts of vermiculite powder, 26-30 parts of santal, 32-36 parts of lysimachia foenum-graecum powder, 26-30 parts of zinc sulfate, 30-34 parts of dipterex, 26-30 parts of chloral hydrate, 30-34 parts of sodium diacetate, 26-30 parts of butyl hydroxyanisole, 30-34 parts of sodium dehydroacetate, 26-30 parts of polyglycerol, 30-34 parts of olive oil macrogol ester, 26-30 parts of nimbin, 30-34 parts of buprofezin, 26-30 parts of rare earth cerium oxide powder, 30-34 parts of butene-fipronil, 26-30 parts of agritol, 30-34 parts of Dupont curzate, 26-30 parts of thiacloprid and 1000-2000 parts of water. The treating agent has excellent sterilization and mildew-proof performances, and raises the garden seed survival rate.