3 results about "Chloral hydrate" patented technology

The invention discloses a preparation method of chloral hydrate oral liquid, which comprises the following steps: 1) preparation of chloral hydrate microspheres: dissolving chloral hydrate in an organic solvent, and then adding a carrier material into the solution to obtain an oil phase; adding a surfactant into deionized water to form a water phase; slowly dropwise adding the oil phase into the water phase while stirring and performing ultrasonic treatment to obtain an emulsion; continuously stirring the emulsion, removing the organic solvent, gradually solidifying the medicine and the carrier material in the oil phase to form microspheres, washing, separating and drying to obtain chloral hydrate microspheres; 2) preparation of chloral hydrate oral liquid: dissolving sorbitol in water to obtain a sorbitol aqueous solution; and adding the chloral hydrate microspheres into a sorbitol aqueous solution to obtain the chloral hydrate oral liquid. The chloral hydrate oral liquid prepared by the method has relatively high stability, and meanwhile, the acceptability of a patient is improved.

The present application relates to the chemical technology field, specifically to a kind of preparation method of high-purity o-vanillin.The method uses o-methoxyphenylamine as starting material, with chloral hydrate and hydroxylamine hydrochloride is condensed, hydroxylamine oximation reaction, and cyclization reaction is carried out under strong acid condition, and compound 2 is generated;Compound 2 is oxidized under strong base condition, and compound 3 is generated;Compound 3 is esterified with primary alcohol to generate corresponding ester, and then reduction hydrogenation reaction is carried out under the action of strong reducing agent, and compound 4 is generated;Compound 4 is reacted with oxidizing agent in the presence of nitroxyl radical catalyst, and compound 5 is generated;Compound 5 carries out diazotization hydrolysis reaction, and o-vanillin is generated.The method avoids the problem of regioselectivity of traditional formylation reaction through specific reaction sequence, eliminates the generation of isomer impurities from the source, realizes the efficient, environmentally friendly, economic synthesis of high-purity o-vanillin, and provides high-quality raw material guarantee for downstream pharmaceutical.

The invention relates to the field of drug detection and analysis, in particular to a method for detecting degraded impurities such as carboxylic acids and aldehydes of chloral hydrate. According to the detection method, high performance liquid chromatography is adopted, octadecyl silane bonded silica gel is adopted as a filling agent, an ultraviolet detector is adopted, and the detection wavelength is 195 nm + / -2 nm. According to the detection method, effective separation of auxiliary material peaks and related substances can be achieved, peak patterns of all peaks are good, the separation degree between impurity peaks and main peaks and the separation degree between the impurity peaks meet the requirements of pharmacopeia, and specificity is good. The method is suitable for drug registration quality research of chloral hydrate and preparations thereof.