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Kit containing chloral hydrate and application of kit

The technology of chloral hydrate and medicine box is applied in the directions of medical preparations with inactive ingredients, containers with multiple items, medical containers, etc., which can solve the problem of difficulty in obtaining chloral hydrate preparations, inconvenient use of injections, and poor compliance of children. and other problems, to achieve the effect of easy operation, good compliance, and improved stability

Active Publication Date: 2020-12-01
TEFENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, effectively improving the stability of chloral hydrate oral solution becomes a difficult problem, and there is no effective method report always
In addition, hospital preparations are limited to the use of this preparation in hospitals and are not allowed to be sold externally. For the large number of small and medium-sized hospitals and grass-roots hospitals that do not have the preparation conditions, it is difficult to obtain chloral hydrate preparations. Clinicians often have to choose phenobarbital with severe side effects Drugs such as sodium, propofol, and ketamine injections
Compared with oral drugs, injections are inconvenient to use and poor compliance in children

Method used

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  • Kit containing chloral hydrate and application of kit
  • Kit containing chloral hydrate and application of kit
  • Kit containing chloral hydrate and application of kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 chloral hydrate concentrate

[0047] Take anhydrous citric acid (0.1g), put it in a glass beaker, add purified water (3.3g), stir to dissolve, slowly and continuously add chloral hydrate (10g) under stirring, stir at a constant speed (300r / min) until complete Dissolve, filter, and pot to obtain chloral hydrate concentrated solution (pH 1.25).

Embodiment 2

[0048] The preparation of embodiment 2 dilution

[0049] Take purified water (0.91ml), put it in a beaker, add sodium benzoate (0.1g), stir and dissolve to obtain a sodium benzoate solution.

[0050] Take another purified water (45.5ml), put it in a glass beaker, heat to boil, add sucrose (60.05g), sucralose (0.1g) and edetate disodium (0.01g), stir to dissolve, boil for 30min, stop heating , cooled to below 80°C, added anhydrous citric acid (0.91g), sodium benzoate solution and raspberry essence (0.4g), added purified water to make up to 91ml, stirred well, filtered, potted, and the diluted solution was obtained (pH 2.48).

Embodiment 3

[0051] The preparation of embodiment 3 dilutions

[0052] Take purified water (0.91ml), put it in a beaker, add sodium benzoate (0.1g), stir and dissolve to obtain a sodium benzoate solution.

[0053] Take another purified water (45.5ml), put it in a glass beaker, heat to boil, add sucrose (60.05g) and sucralose (0.1g), stir to dissolve, boil for 30min, stop heating, cool to below 80°C, add anhydrous Citric acid (0.91g), sodium benzoate solution and raspberry essence (0.4g), add purified water to make up to 91ml, stir well, filter, potting, and obtain the diluted solution (pH2.36).

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PUM

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Abstract

The invention relates to a kit comprising a first container containing a chloral hydrate concentrate and a second container containing a diluent and application of the chloral hydrate concentrate andthe diluent to preparation of a medicament for use as a sedative-hypnotic agent.

Description

technical field [0001] The present invention relates to a kit comprising a first container containing a chloral hydrate concentrate and a second container containing a diluent, and the use of said chloral hydrate concentrate and diluent in the preparation of a medicament for use as a sedative-hypnotic agent. Background technique [0002] Diagnosis and treatment of childhood illnesses often require multiple medical tests such as MRI, CT, EKG, EEG, eye exams, dental exams, etc. As a special group, children have immature psychological development, and their ability to control their own emotions and behaviors in the process of diagnosis and treatment is far inferior to that of adults. The process is difficult. For this reason, before diagnosis and treatment, children are often required to take sedative hypnotics to keep them calm, reduce anxiety and fear, and ensure the smooth progress of the diagnosis and treatment process. [0003] At present, clinically, chloral hydrate ora...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B65D81/32A61K31/11A61K9/00A61K9/08A61K47/26A61P25/20A61J1/05
CPCB65D81/32A61K31/11A61K9/0095A61K9/08A61K47/26A61P25/20A61J1/05A61K9/00
Inventor 陶亮云琦孙媛媛
Owner TEFENG PHARM CO LTD
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