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Kit containing chloral hydrate and use thereof

A technology of chloral hydrate and medicine box, which is applied in the direction of medical preparations with non-active ingredients, containers with multiple items, medical containers, etc., and can solve problems such as poor compliance of children, inconvenient use of injections, and large toxic and side effects

Active Publication Date: 2022-07-22
TEFENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, effectively improving the stability of chloral hydrate oral solution becomes a difficult problem, and there is no effective method report always
In addition, hospital preparations are limited to the use of this preparation in hospitals and are not allowed to be sold externally. For the large number of small and medium-sized hospitals and grass-roots hospitals that do not have the preparation conditions, it is difficult to obtain chloral hydrate preparations. Clinicians often have to choose phenobarbital with severe side effects Drugs such as sodium, propofol, and ketamine injections
Compared with oral drugs, injections are inconvenient to use and poor compliance in children

Method used

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  • Kit containing chloral hydrate and use thereof
  • Kit containing chloral hydrate and use thereof
  • Kit containing chloral hydrate and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 chloral hydrate concentrate

[0047] Take anhydrous citric acid (0.1g), put it in a glass beaker, add purified water (3.3g), stir to dissolve, slowly and continuously add chloral hydrate (10g) under stirring, and stir at a constant speed (300r / min) until complete Dissolve, filter, and seal to obtain chloral hydrate concentrate (pH 1.25).

Embodiment 2

[0048] Preparation of Example 2 Diluent

[0049] Take purified water (0.91ml), put it in a beaker, add sodium benzoate (0.1g), stir to dissolve, and obtain a sodium benzoate solution.

[0050] Take another purified water (45.5ml), put it in a glass beaker, heat to boil, add sucrose (60.05g), sucralose (0.1g) and disodium edetate (0.01g), stir to dissolve, boil for 30min, stop heating , cooled to below 80°C, add anhydrous citric acid (0.91g), sodium benzoate solution and raspberry essence (0.4g), add purified water to make up to 91ml, stir well, filter, potting to get the dilution (pH 2.48).

Embodiment 3

[0051] Example 3 Preparation of Diluent

[0052] Take purified water (0.91ml), put it in a beaker, add sodium benzoate (0.1g), stir to dissolve, and obtain a sodium benzoate solution.

[0053] Take another purified water (45.5ml), put it in a glass beaker, heat to boil, add sucrose (60.05g) and sucralose (0.1g), stir to dissolve, boil for 30min, stop heating, cool to below 80°C, add anhydrous Citric acid (0.91g), sodium benzoate solution and raspberry essence (0.4g) were added with purified water to make up to 91ml, stirred well, filtered and potted to obtain a diluent (pH 2.36).

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Abstract

The present invention relates to a kit comprising a first container containing a chloral hydrate concentrate and a second container containing a diluent and the use of the chloral hydrate concentrate and the diluent in the preparation of a medicament for use as a sedative-hypnotic agent.

Description

technical field [0001] The present invention relates to a kit comprising a first container containing a chloral hydrate concentrate and a second container containing a diluent and the use of the chloral hydrate concentrate and the diluent in the preparation of a medicament for use as a sedative-hypnotic agent. Background technique [0002] Diagnosis and treatment of children's diseases usually require a variety of medical examinations, such as MRI, CT, ECG, EEG, eye examination, dental examination, etc. As a special group, children are not yet mature in their psychological development, and their ability to control their own emotions and behaviors in the process of diagnosis and treatment is far less than adults. The process is difficult to carry out. For this reason, before diagnosis and treatment, children are often required to take sedative-hypnotic agents to keep them calm, reduce anxiety and fear, and ensure the smooth progress of the diagnosis and treatment process. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B65D81/32A61K31/11A61K9/00A61K9/08A61K47/26A61P25/20A61J1/05
CPCB65D81/32A61K31/11A61K9/0095A61K9/08A61K47/26A61P25/20A61J1/05A61K9/00
Inventor 陶亮云琦孙媛媛
Owner TEFENG PHARM CO LTD
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