Helicid modifier and its preparation method and uses

A technology of tofu fruit glycosides and modifiers, which is applied in the field of novel tofu fruit glycoside modifiers, and can solve problems such as no tofu fruit sugar modifiers

Inactive Publication Date: 2008-08-27
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no any report of tofu fruit sugar modifier

Method used

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  • Helicid modifier and its preparation method and uses
  • Helicid modifier and its preparation method and uses
  • Helicid modifier and its preparation method and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Preparation of tetraacetylated tofu glucoside.

[0016] Take 200g tofu glucoside and dissolve it in 200mL pyridine, add 400mL acetic anhydride, heat in a water bath at 60°C for 3 hours, add an appropriate amount of water directly to the reactant to precipitate a solid, mash the precipitated solid, and successively use 1000ml dilute hydrochloric acid (2%) and 1000ml Sodium carbonate (5%) aqueous solution was suction-filtered 3 times on a Buchner funnel, then rinsed with water, heated and dissolved in 500ml 95% alcohol solution, crystallized and recrystallized repeatedly to obtain 283g tetraacetylated tofu glucoside, obtained The rate is 88.9%.

[0017] Structural identification data of tetraacetylated tofu glucoside:

[0018] Ultraviolet spectrum (UV) was measured with UV-210A instrument. Infrared spectrum (IR) was measured with a Bio-RadFTS-135 spectrophotometer, and KBr pellets were used. The polarimeter uses a JASCO-20 polarimeter. Melting point with X-...

Embodiment 2

[0032] Example 2: Preparation of tetrasuccinic acid half ester tofu glucoside.

[0033] Dissolve 0.7g tofu fruit glycosides in 5mL pyridine, add 1g succinic anhydride and 1.14g 4-N,N-lutidine (DMAP), heat in a water bath at 60°C for 3 hours, add appropriate amount of water to the reactant, and wash with chloroform After three extractions, the chloroform part was subjected to gel (Sephadex LH-20) chromatography (mobile phase: chloroform:methanol=1:1) to obtain 1.42 g of tetrasuccinic acid half ester curin, with a yield of 84.2%.

[0034] Structural identification data of tetrasuccinic acid half ester tofu glucoside:

[0035] The polarimeter uses a JASCO-20 polarimeter. Mass Spectrum (MS) was measured with Auto SPEC 3000 mass spectrometer. NMR spectrum ( 1 H NMR and 13 C NMR) was measured with Bruker DRX-400 superconducting nuclear magnetic resonance instrument, TMS was used as internal standard, CD 3 OD as solvent.

[0036] The structural formula is as shown in formula (I...

preparation Embodiment 1

[0047] [Formulation Example 1] Tablet

[0048] Tablets are prepared according to methods known in the art, each containing the following ingredients:

[0049] Formula (I) compound 50mg

[0050] Lactose 70mg

[0051] Magnesium Stearate 3mg

[0052] Polyvinylpyrrolidone 7mg

[0053] Total 130mg

[0054] The tablets may, if desired, be film-coated with hydroxypropylmethylcellulose, talc and coloring agents.

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Abstract

The invention discloses a new decorative of bean curd with structure formula (I), which is characterized by the following: adopting the decorative as active component of drug component; fitting for preparing sedative-hypnotic and antiphlogistic anodyne.

Description

Technical field: [0001] The present invention relates to a novel modified tofu glucoside, a preparation method thereof, a pharmaceutical composition containing the modified tofu glucoside as an active ingredient, and their application in the preparation of sedative and hypnotic drugs and in the preparation of anti-inflammatory and analgesic drugs . Background technique: [0002] Tofu glucoside (Helicid) is an active ingredient monomer glycoside (4-formylphenyl-β-allose) extracted from the fruits of several plants of the genus HeliciaLour. Anti-inflammatory and analgesic effect. In the prior art, there is no any report of tofu fruit sugar modification. Invention content: [0003] The object of the present invention is to provide a new class of tofu glucoside modification with medicinal value and its preparation method, and the further object is to provide the compound tofu glucoside modification of the present invention in the preparation of sedative hypnotic drugs and an...

Claims

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Application Information

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IPC IPC(8): C07H15/20C07H13/06C07H13/08A61K31/7034A61P25/20A61P29/00
Inventor 周俊赵友兴陈纪军尚建华刘玉清朱兆云王京昆赵云丽
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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