Capsular coronary compression device and method for making animal model of chronic myocardial ischemia

Abstract

The invention discloses a capsule type coronary oppressing device and a method for manufacturing a chronic myocardial ischemia animal model. The capsule type coronary oppressing device at least comprises a capsule body and an injection pipe communicated with the capsule body. The method for manufacturing a chronic myocardial ischemia animal model includes the steps that firstly, an animal sample is fixed on an experiment table; secondly, a skin is shaved; thirdly, the thoracic cavity is cut open and the heart is exposed; fourthly, the coronary artery is extracted, the capsule body of the capsule type coronary oppressing device is fixed on the myocardium and bundled with the coronary artery, and at least a rubber tube section of the injection pipe of the capsule type coronary oppressing device is fixed below the skin of the animal sample; fifthly, the thorax is closed for feeding. According to the capsule type coronary oppressing device and the method for manufacturing the chronic myocardial ischemia animal model, the chronic myocardial ischemia animal model which can perform multiple times of intermittent ischemia reperfusion on the cardiac muscle and can be continuously studied can be constructed. New ideas and a basis can be provided for treating the ischemic cardiomyopathy in clinic work, and new progresses can be provided for treatment theories of the ischemic cardiomyopathy.

Description

technical field [0001] The invention relates to a capsule coronary compression device and a method for manufacturing a chronic myocardial ischemia animal model using the capsule coronary compression device to compress animal coronary arteries. Background technique [0002] Drugs, interventional therapy and surgery are effective means to treat myocardial ischemia. Reversal of ventricular remodeling after adequate revascularization is an important factor to improve the survival rate of patients and affect the long-term mortality. Coronary artery intervention (PCI) or coronary artery bypass grafting (CABG), which are widely used clinically at present, are effective means to unblock infarcted vessels and restore myocardial blood supply, but for diffuse multivessel disease, coronary artery lumen Extensive thinning and narrow inner diameter, the treatment effect of conventional treatment methods is often poor. A large number of studies have shown that the greater omentum has a ri...

AI Technical Summary

Problems solved by technology

[0005] Patent application 200820156364.9 discloses a time-controlled arterial constriction ring, which is placed on the coronary blood vessels of animal samples, and the coronary arteries are swelled slowly by absorbing water in the blood of animal samples with a high water-swellable resin. Compression, this kind of narrowing ring uses a single material, the narrowing progress is relatively fixed, the maneuverability is poor, the price is expensive, and the time from ischemia to infarction is relatively short, usually 1-2 weeks, which is similar to that of chronic myocardial infarction in common clinical cases. The blood disease course (months, years) is quite different, and the compression on the coronary artery is not reversible, the time available for research is short, and the animal samples eventually die, so it is impossible to establish a myocardial ischemia model for continuous research

Some studies have also established a chronic myocardial ischemia model by injecting isoproterenol to cause increased myocardial oxygen consumption and myocardial ischemia due to coronary artery spasm.

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