Use of leonurine in preparing medicine for preventing and treating ischemic cardiomyopathy

A technology of ischemic cardiomyopathy and motherwort, which is applied in drug combinations, cardiovascular system diseases, and pharmaceutical formulations, and can solve problems such as the lack of protective effect of motherurine on myocardial ischemia.

Active Publication Date: 2009-02-04
ZHUHAI HENGQIN NEW DISTRICT ZHONGZHU ZHENGTAI MEDICAL MANAGEMENT CO LTD
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Leonurine is a specific component of traditional Chinese medicine Leonurine. It has been reported in literature that Leonurine can significantly inhibit the contraction of vascular smooth muscle by inhibiting the influx of external calcium and the release of internal calcium. There is no research on the protective effect of Leonurine on myocardial ischemia. to report

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of leonurine in preparing medicine for preventing and treating ischemic cardiomyopathy
  • Use of leonurine in preparing medicine for preventing and treating ischemic cardiomyopathy
  • Use of leonurine in preparing medicine for preventing and treating ischemic cardiomyopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 In vitro hypoxia model experiment of leonurine

[0037] The present invention detects the cell survival rate with the method of MTT analysis, adopts the hypoxia model of this field experiment routine, uses losartan as positive control drug, and the concentration of the selected motherwort is 10 -6 mmol / L, the experimental data were analyzed by one-way analysis of variance, p<0.01, the results showed that motherwort can significantly improve the survival rate of hypoxic cells and the survival rate of ischemic cardiomyocytes;

[0038] Cell death can lead to the leakage of lactate dehydrogenase. By detecting and analyzing the amount of LDH leakage into the culture medium, the results show that motherwortine can significantly reduce the leakage of lactate dehydrogenase. One-way analysis of variance, p<0.01;

[0039] The active reaction of catalase is the ability to scavenge free radicals, and the experiment of the present invention shows that motherwortine can...

Embodiment 2

[0043] Myocardial infarction model test of embodiment 2 leonurine

[0044] Using the mature myocardial infarction model of ligation of the anterior descending coronary artery in the field, the method of intraperitoneal injection was used, and the infarct area was detected by the method of TTC staining. The experimental data was analyzed by one-way analysis of variance. Significantly reduce the size of myocardial infarction.

[0045] Myocardial infarction can lead to the release of myocardial enzymes LDH and CK into the plasma, and the said motherurine can significantly reduce the levels of LDH and CK in the plasma, and reduce the degree of myocardial damage. One-way analysis of variance, p<0.05.

[0046] MDA reflects the degree of lipid peroxidation damage. Superoxide dismutase (SOD) plays a vital role in the body's oxidation and antioxidant balance. This enzyme can remove superoxide anion free radicals and protect cells from damage, the results of this experiment show that t...

Embodiment 3

[0049] The heart failure model test of embodiment 3 leonurine

[0050] The present invention uses the mature heart failure model of ligation of the anterior descending coronary artery in the field, adopts the method of intraperitoneal administration, and uses the method of arterial and ventricular intubation to detect cardiac function, and the results show that motherwort can reduce ventricular end-systolic pressure , increase the contraction rate, improve heart function. One-way analysis of variance, p<0.05.

[0051] The content of vitamin C and cysteine ​​in plasma was detected by capillary electrophoresis. The results show that motherwortine can increase vitamin C and decrease cysteine ​​content in blood plasma, and motherwortine can improve antioxidant capacity, single factor analysis of variance, p<0.05.

[0052] Table 1 is the test results of cardiac function in the heart failure model, showing that motherwort improves the cardiac function of rats with myocardial infar...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the Chinese medicine pharmaceutical field and relates to the application of specific monomer leonurine in Chinese medicinal herb motherwort in preparing medicine combination, in particular to the application in preparing the medicine combination which cures ischemic cardiomyopathy. By the experimental research of anoxic myocardium models in vitro, the result shows that the leonurine can increase livability of ischemic myocyte, can decrease the leakage rate of lactate dehydrogenase, can increase the activity of antioxidase catalase, can increase the activity of SOD, can minish the level of lipid peroxidation products, and proves that the leonurine has obvious protective effect on ischemic myocardium and prepares the medicine which cures ischemic cardiomyopathy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to the application of the specific monomer leonurine in the Chinese herbal medicine motherwort in the preparation of pharmaceutical compositions, especially the application in the preparation of pharmaceutical compositions for preventing and treating ischemic cardiomyopathy. Background technique [0002] Ischemic cardiomyopathy, especially acute myocardial infarction, has been the leading cause of death in both developed and developing countries in recent decades. Studies have shown that the increase in the production of reactive oxygen species (Reactive oxygen species, ROS) in the body exceeds the scavenging capacity of the endogenous antioxidant system, resulting in oxidative stress, which can accelerate the aging of the human body, increase the incidence of tumors, and cause cardiovascular system damage. The injury, aggravating the degree of myocardial damage. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/235A61P9/10
CPCA61K31/24A61P9/00A61P9/04A61P9/10A61P43/00
Inventor 朱依谆刘新华朱依纯侯爱君孙逊
Owner ZHUHAI HENGQIN NEW DISTRICT ZHONGZHU ZHENGTAI MEDICAL MANAGEMENT CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap