3results about How to "Good cell membrane permeability" patented technology

The application provides a fluorescent probe compound for simultaneously detecting HClO and SO2 at double sites and synthesis and application thereof. The probe compound takes phenothiazine as a response group of HClO, expands the conjugated structure of phenothiazine, and introduces a response group of SO2 and an organelle positioning group on the near-infrared fluorescent skeleton, thereby constructing an endoplasmic reticulum-targeted fluorescent probe BQTPA for simultaneously detecting HClO and SO2. The probe can realize dual-channel simultaneous detection of HClO and SO2 through two completely separated emission channels (λem=598 nm and 448 nm), and exhibits excellent selectivity, high sensitivity (detection limits are 7.9 nM and 33.8 nM, respectively) and good light stability to the response of HClO and SO2. The probe is successfully used for monitoring the changes of exogenous and endogenous HClO and SO2 levels in cells, further reveals the dynamic changes of the two in the process of drug-induced liver injury and ferroptosis, and clarifies the role of ferroptosis in liver injury.

The invention discloses aromatic compounds based on a 2, 3-dicyano-5, 10-dihydrophenazine structure as well as a preparation method and application of the aromatic compounds, and relates to the field of organic synthetic chemistry and biological functional materials. The compound based on the 2, 3-dicyano-5, 10-dihydrophenazine structure comprises a donor-DCyPZ structure, a DCyPZ unit serves as a strong electron acceptor and a rigid pi-bridge, and an electron donating group connected with the DCyPZ unit is a functional module capable of being subjected to wide structural modification. By changing the chemical structure of an electron-donating group, the photophysical properties and biological activity of molecules can be systematically adjusted, and the near-infrared luminescent material has efficient near-infrared luminescence in an aggregation state, ultra-large Stokes shift, excellent light stability and phototoxicity and ultrafast cell imaging capability which can be realized without assistance of a nano-carrier. The invention provides a novel fluorescent probe platform which is adjustable in structure, excellent in performance and convenient to apply, and has a wide application prospect in the fields of cell dynamic imaging, tumor monitoring and treatment and the like.

The present invention provides a nucleic acid having excellent cell membrane permeability. The present invention relates to: a nucleic acid having a structure represented by the following general formula (A1) or (A2) [in the formula, R0 is an alkyl group having 1 to 30 carbon atoms that is substituted with one or more fluorine atoms, a group having 1 to 5 etheric oxygen atoms between carbon atoms of an alkyl group having 2 to 30 carbon atoms that is substituted with one or more fluorine atoms, an alkyl group having 10 to 30 carbon atoms that is not substituted with a fluorine atom, or a group having 1 to 5 etheric oxygen atoms between carbon atoms of an alkyl group having 10 to 30 carbon atoms that is not substituted with a fluorine atom; n11 and n12 each independently represent an integer of 1 or more; B is a nucleobase; and a filled circle indicates a bond]; a cell membrane permeabilizing agent containing the nucleic acid as an active ingredient; and a nucleic acid drug containing the nucleic acid as an active ingredient.