Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composite nanomaterial of organic naphthalene and inorganic phosphate

A technology of composite nanomaterials and inorganic phosphates, applied in the field of composite materials, to achieve the effects of good biocompatibility, excellent cell membrane permeability, and low biological toxicity

Active Publication Date: 2016-09-21
HENAN NORMAL UNIV
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Corresponding organic and inorganic composite nanomaterials are rarely reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite nanomaterial of organic naphthalene and inorganic phosphate
  • Composite nanomaterial of organic naphthalene and inorganic phosphate
  • Composite nanomaterial of organic naphthalene and inorganic phosphate

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0060] On the other hand, the present invention provides the preparation method of the above-mentioned composite nanomaterial of organic naphthalene and inorganic phosphate of the present invention, comprising the following steps:

[0061] 1) 4-bromo-1,8-naphthoside and 4-bromoacenaphthenequinone react with L-H in a molar ratio of 1:1-1:6 to prepare compound i and compound ii;

[0062]

[0063] In a specific embodiment, the reaction temperature of the step 1) is 0-200°C, preferably 25-180°C, more preferably 50-180°C, most preferably 60-150°C; the reaction time is 1-36 hours, Preferably 1-23 hours, more preferably 1-22 hours, most preferably 1-20 hours; the reaction solvent is selected from dichloromethane, ethanol, methanol, acetone, 1,4-dioxane, glycerol, Ethyl acetate, acetic acid or mixtures thereof, more preferably dichloromethane, ethanol, methanol, 1,4-dioxane, glycerol, ethyl acetate, acetic acid or mixtures thereof, most preferably ethanol, methanol, glycerol , eth...

Embodiment 1

[0083] Composite nanomaterial A of organic naphthalene and inorganic phosphate 1 (referred to as material A 1 ), the synthetic route is as follows:

[0084]

[0085] (1) Compound A 1 Synthesis of -1

[0086] Add 20mmol of 4-bromo-1,8-naphthoside and 70mmol of diethanolamine into a round bottom flask containing 10ml of ethanol solution under nitrogen protection. The reaction was heated to reflux for 16h and then stopped. The mixture was poured into ice water, precipitated out, and suction filtered to obtain the crude product of yellow solid powder, Compound A 1 -1, yield 90%.

[0087] (2) Compound A 1 Synthesis of -2

[0088] 20mmol compound A 1 -1 and 30mmol of aminovaleric acid were added to a round bottom flask of 20ml of acetic acid solution, under nitrogen protection. The reaction was heated to reflux at 125°C for 12 hours and then stopped. The solvent was distilled off under reduced pressure and separated by column chromatography to obtain compound A as a yel...

Embodiment 2

[0098] Example 2: Material A 1 water solubility detection test

[0099] Using the material A synthesized above 1 Added to water, measured at different concentrations (0.27, 0.65, 0.86, 1.1, 1.5, 2.0, 3.0mg / mL) A 1 Absorbance at the wavelength of maximum absorption of an aqueous solution. The test result is image 3 , shows: when material A 1When the concentration is 2.0mg / mL, the absorbance value does not shift, that is, material A 1 The solubility in water is 2.0mg / mL.

[0100] The instruments used in this example are Agilent 8453 UV spectrophotometers.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
densityaaaaaaaaaa
Login to View More

Abstract

The invention provides a composite nanomaterial of organic naphthalene and inorganic phosphate, and the composite nanomaterial has the structure of general formula I shown in the description. The composite nanomaterial can perform identification, adsorption, clearance and transport of the heavy metal in the living cell, and can show obvious different identification signals in the adsorption process of the heavy metal in the living cell. The material has a certain level of water solubility, has good membrane permeability, and has low biotoxicity, phototoxicity, and photobleaching property. The spectral region of the material has enough large difference with the spectral region of the biological sample.

Description

technical field [0001] The invention relates to a kind of composite material which can be used for the identification and adsorption of heavy metals in living cells, especially the composite material of fluorescent organic naphthalene and inorganic phosphate. Background technique [0002] Heavy metals refer to metals with a density greater than 4.5 grams per cubic centimeter, such as lead (Pb), cadmium (Cd), chromium (Cr), mercury (Hg), copper (Cu), gold (Au), silver (Ag), etc. Heavy metals can strongly interact with proteins and enzymes in the human body, making them inactive, and may also accumulate in certain organs of the human body, causing chronic poisoning. Mercury (Hg), for example, mainly harms the nervous system, damages the brain, causes limb numbness, movement disorders, narrowed vision, and hearing difficulties caused by mercury poisoning encephalopathy. In severe cases, heart failure leads to death. People with severe poisoning may have symptoms such as oral l...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D221/14C07D471/06C07D413/04G01N21/64
CPCC07D221/14C07D413/04C07D471/06G01N21/6428
Inventor 仉华范灵超杜思雨吴呈珂姚美焕王魁
Owner HENAN NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com