Near infrared fluorescence probe adopting nile blue as parent, preparation method thereof and applications thereof

A fluorescent probe, Nile blue technology, applied in the field of near-infrared fluorescent probes, can solve the problems of lack of imaging specificity, increase accurate diagnosis, large radioactivity, etc., achieve good cell membrane permeability, low biological toxicity, synthetic easy effect
CN103820104AActive Publication Date: 2014-05-28SICHUAN ANKERUI NEW MATERIAL TECH CO LTD
4 Cites 12 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN ANKERUI NEW MATERIAL TECH CO LTD
Publication Date
2014-05-28

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a near infrared fluorescence probe adopting nile blue as a parent, a preparation method thereof and applications thereof. The fluorescence probe has a structure shown as the general formula I as the attached drawing 1. The fluorescence probe can effectively improve deficiencies of tumor labeling fluorescence probes at present, can sensitively and accurately response to target cells COX-2 expression amount of which is abnormal, and is suitable for effective specific near infrared fluorescence probes labeling living tumor cells. The fluorescence probe provided by the invention is simple in synthesis and products are easy to obtain. The fluorescence probe provided by the invention has a very low fluorescence background in non-tumor cells and high fluorescence signals in tumor cells, and has strong specific labeling function for tumor cells. In addition, compounds of the type have good cell membrane permeability, low biotoxicity, low phototoxicity and low photobleaching capability and can locate a special organelle of a certain kind tumor cell.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a kind of near-infrared fluorescent probe with Nile blue as the matrix, its preparation method, and the application of the fluorescent probe in the preparation of biomarker kits, especially tumor cell marker kits. Background technique

[0002] According to the statistics of the World Health Organization (WHO), in the 1980s, there were about 7 million new cancer patients in the world every year, and about 5 million people died of cancer every year. Cancer is attacking human beings with an irresistible trend. It is an important work to find a simple, fast, effective and sensitive cancer marker technology. The existing marker imaging methods mainly include: X-ray detection technology, ultrasonic detection technology, CT detection technology, nuclear magnetic resonance (MRI) detection technology, infrared thermal imaging detection technology, near-infrared scanning detection technology, PET-CT detection technology, etc. . However...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More