Pseuoginsenoside F11 phospholipid complex as well as preparation method and application thereof

A technology for simulating ginsenoside and phospholipid complexes, which is applied in the directions of pharmaceutical combinations, pharmaceutical formulations, and inactive medical preparations, etc., to achieve the effects of facilitating industrial production, improving oral bioavailability, and enhancing curative effects

Active Publication Date: 2013-05-22
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are no relevant patent reports on the preparation and application of pseudoginsenoside F11 phospholipid complex

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  • Pseuoginsenoside F11 phospholipid complex as well as preparation method and application thereof
  • Pseuoginsenoside F11 phospholipid complex as well as preparation method and application thereof
  • Pseuoginsenoside F11 phospholipid complex as well as preparation method and application thereof

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preparation example Construction

[0043] A method for preparing the phospholipid complex of pseudo-ginsenoside F11 as described above, characterized in that: the steps are as follows:

[0044] (1) Uniformly disperse the phospholipids in the aqueous solution of the hydrophilic carrier by magnetic stirring;

[0045](2) Add pseudo-ginsenoside F11 into the aqueous solution of hydrophilic excipients dispersed with phospholipids in 2-6 times according to the above ratio, and pass through at 1500r·min -1 Grinding in a high-speed grinding machine for 1h-6h to prepare the grinding suspension of the phospholipid complex of pseudoginsenoside F11.

[0046] During the preparation of the above-mentioned grinding suspension, the pseudo-ginsenoside F11 was added to the aqueous solution of hydrophilic adjuvant dispersed with phospholipids in 4 times, at 1500r min -1 Grind for 3 hours in a grinder running at high speed.

[0047] Pharmaceutically acceptable excipients should be added to the grinding suspension of the phospholi...

Embodiment 1

[0060] Grinding suspension of pseudoginsenoside F11: 30g of pseudoginsenoside F11, 300g of hydrogenated soybean lecithin, 30g of hydroxypropyl cellulose (HPC), 270g of distilled water; Propyl cellulose aqueous solution; take 300g of hydrogenated soybean lecithin and evenly disperse in the hydroxypropyl cellulose aqueous solution; weigh 30g of pseudoginsenoside F11 crude drug, divide it into 2 batches of feeding, and place it together with the above-mentioned hydroxypropyl cellulose aqueous solution in the grinding In the cup, at 1500r·min -1 Grind for 3 hours in a grinding machine running at high speed to obtain the pseudo-ginsenoside F11 phospholipid complex grinding suspension (hereinafter referred to as: pseudo-ginsenoside F11 grinding suspension). After grinding, the average particle size of pseudoginsenoside F11 raw material is reduced to less than 1 μm under a microscope.

Embodiment 2

[0062] Grinding suspension of pseudoginsenoside F11: 150g of pseudoginsenoside F11, 75g of soybean lecithin, 5g of hydroxypropyl cellulose (HPC), 45g of distilled water; Propyl cellulose aqueous solution; take 75g of soybean lecithin and evenly disperse in the hydroxypropyl cellulose aqueous solution; weigh 50g of pseudoginsenoside F11 crude drug, divide it into 2 batches of feeding, and place it together with the above-mentioned hydroxypropyl cellulose aqueous solution in the grinding In the cup, at 1500r·min -1 Grind for 1 hour in a high-speed grinding machine to obtain a grinding suspension of pseudoginsenoside F11. After grinding, the average particle size of pseudoginsenoside F11 raw material is reduced to less than 1 μm under a microscope.

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Abstract

The invention discloses a pseuoginsenoside F11 phospholipid complex as well as a preparation method and application of the pseuoginsenoside F11 phospholipid complex and belongs to the field of pharmaceutic preparations. The preparation method of the pseuoginsenoside F11 phospholipid complex comprises the following steps of: dispersing phospholipid in a hydrophilic carrier solution with a certain concentration, then adding pseuoginsenoside F11 to obtain a mixture, and then grinding the mixture into a suspension solution with the particle size being smaller than 1000nm, wherein the medicine, namely the pseuoginsenoside F11 and the phospholipid mutually act to form a phospholipid compound. The pharmaceutic liposolubility of the prepared phospholipid compound is increased, the permeability of the prepared phospholipid compound on cell membranes is increased, and therefore the bioavailability of the pseuoginsenoside F11 is greatly improved; the phospholipid compound can be prepared into quick-release pellets; and the activity of the prepared pseuoginsenoside F11 quick-release pellets is remarkably improved. No organic solvent is used in the preparation process, so that the environmental pollution is avoided and the production safety is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a phospholipid complex of pseudo-ginsenoside F11, a preparation method thereof, and an application thereof in pharmaceutical preparations. Background technique [0002] Pseudo-ginsenoside F11 belongs to octilon-type ginsenoside, which is a tetracyclic three-mushroom glycoside compound whose side chain is a bark ring. It is a component extracted from American ginseng. In recent years, it has also been found in Panax ginseng, Pearl ginseng, Panax notoginseng and Vietnamese ginseng. Molecular formula is C 42 h 72 o 14 , the molecular weight is 801.03, and the structural formula is as follows: [0003] [0004] At present, the pharmacological research of pseudo-ginsenoside F11 mainly contains the following aspects: (1) octilone type soap has the effect of antagonizing the formation of morphine physical dependence and mental dependence and antagonizing met...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/7048A61K47/24A61K47/48A61P25/36A61P9/10A61P25/28
Inventor 吴春福杨静玉唐星王芳王立辉
Owner SHENYANG PHARMA UNIVERSITY
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