Polypeptide for carrying out targeting on mitochondria, and preparation method and application of polypeptide

A mitochondrial and targeted technology, applied in the field of biomedicine, can solve the problems of difficult multi-functional targeted modification and inability to target release of active substances without traces, and achieves a simple synthesis method, convenient multi-functional modification, and good biocompatibility. Effect
CN113616807AActive Publication Date: 2021-11-09SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2021-11-09

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Abstract

The invention discloses a polypeptide for carrying out targeting on mitochondria, and a preparation method and application of the polypeptide. The polypeptide is briefly recorded as MTPs. The polypeptide, which is prepared by the scheme of the invention, for carrying out the targeting on the mitochondria has a simple in synthesis method, and the obtained polypeptide can specifically carry out targeting on the cell mitochondria, is almost non-toxic to cells, has good cell membrane penetration characteristics, can be conveniently subjected to further multifunctional derivative modification, and provides a potential delivery tool for preparation of mitochondrial targeting drugs.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to a mitochondria-targeting polypeptide and its preparation method and application. Background technique

[0002] Cancer (malignant tumor) has become a major disease that seriously endangers human health, and has brought enormous pressure to people's lives and economic and social development. Although tremendous progress has been made in the prevention, detection, and treatment of cancer, there are currently no effective therapies for treating tumors. A long-standing problem in cancer chemotherapy is the non-specific distribution of therapeutic drugs and lack of tumor selectivity, which can lead to systemic toxicity and other serious side effects during treatment, such as alopecia, anemia, kidney, liver and bone marrow damage, etc. Therefore, it is of great significance to develop an effective anticancer drug delivery system to distinguish cancer cells from normal cells, so a...

Claims

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