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Zinc ion fluorescence probe compound, preparation method and application

A fluorescent probe and compound technology, applied in the field of analytical chemistry, can solve the problems of deviation of measurement results and insufficient selectivity, and achieve the effects of simple structure, good selectivity, and strong anti-interference ability of other metal ions

Inactive Publication Date: 2016-05-04
INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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Problems solved by technology

But they generally have some problems, such as insufficient selectivity, the influence of factors such as ambient temperature, solvent polarity, pH value, fluorophore concentration, instruments and equipment, etc., resulting in large deviations in the measurement results.

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  • Zinc ion fluorescence probe compound, preparation method and application
  • Zinc ion fluorescence probe compound, preparation method and application
  • Zinc ion fluorescence probe compound, preparation method and application

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Embodiment Construction

[0046] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and through specific implementation methods.

[0047] Such as figure 1 As shown in a, 2-(2'-hydroxyphenyl)benzoxazole (HBO) has the characteristics of ketone and enol dual emission ratio fluorescent probes, which can effectively eliminate the data distortion caused by the above factors, so that The measurement results are more accurate. Moreover, it has the advantages of high fluorescence quantum yield and large Stokes shift, and is expected to become an ideal fluorophore molecule for zinc ion fluorescent probes.

[0048] For Zn 2+ For , the classical recognition group R moiety is ethylenediaminetetraacetic acid (EDTA) (eg figure 1 b) and N,N,N,N-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) (such as figure 1 c) and its derivatives. EDTA on Zn 2+ and Cd 2+ There is no selectivity, therefore, simply using EDTA as a fluorescent probe for ...

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Abstract

The invention discloses a zinc ion fluorescence probe compound, a preparation method and application and relates to the technical field of analytical chemistry. The chemical formula of the zinc ion fluorescence probe compound is C39H35N7O2, and the zinc ion fluorescence probe compound is obtained by using 2-(2'-hydroxy phenyl) benzoxazole compound as a parent structure and performing derivatization. The zinc ion fluorescence probe compound has good selectivity, high sensitivity and good capability of resisting interference of other metal ions and is an ideal zinc ion sensing molecule.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry, in particular to a zinc ion fluorescent probe compound, a preparation method and an application thereof. Background technique [0002] Zinc ion is an important trace element and the second most abundant metal cation in human body after iron ion. It plays key roles in living organisms, such as neurotransmission, enzyme regulation, gene expression and apoptosis. Many studies have shown that zinc deficiency can lead to various clinical diseases such as growth retardation, immune system dysfunction, anorexia and skin damage. Additionally, zinc imbalances have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and epilepsy, among others. Therefore, the highly selective identification and detection of zinc ions is of great significance to chemistry, biology, clinical medicine and other disciplines. [0003] C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D413/14C09K11/06G01N21/64
CPCC07D413/14C09K11/06C09K2211/1007C09K2211/1029C09K2211/1033G01N21/64G01N2021/6417
Inventor 王凤忠陈卫华尚玉婷范蓓单吉浩李敏敏卢嘉刘佳萌
Owner INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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