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Application of bronopol and analogue thereof in drug preparation

A technology of Bropol and analogues, applied in the field of medicine, can solve problems such as bacterial infections that have never been seen, and achieve the effect of rich sources and good therapeutic effects

Inactive Publication Date: 2014-12-17
李志海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There have been no reports of these two compounds treating bacterial infections, especially animals infected with multi-drug resistant bacteria.

Method used

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  • Application of bronopol and analogue thereof in drug preparation

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Embodiment Construction

[0010] In order to better understand the essence of the present invention, the following pharmacological experiments and clinical trials and results of Bropol and its analogues illustrate their new applications in the field of pharmacy.

[0011] 1. Preparation

[0012] 1. Preparation of Bropol soluble powder: Take 1000g of Bropol, mix it with 4000g of anhydrous glucose, pack it into 100g / bag, and set aside.

[0013] 2. Preparation of 2,2-dibromo-2-nitroethanol soluble powder: 1Kg of 2,2-dibromo-2-nitroethanol was mixed with 19Kg of 100 mesh glucose, dried at 60°C for 3 hours, mixed evenly, and packaged Make 100g / bag and set aside.

[0014] 3. Preparation of Bropol Capsules: Grind 100g Bropol 60 mesh, mix with 900g 60 mesh anhydrous glucose, add a small amount of magnesium stearate and mix evenly, pack into 0.5g / capsule, 2000 capsules, each Capsules contain 50 mg of Bropol for oral administration.

[0015] Bropol and its analogues can also be made into other different dosage...

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Abstract

The invention relates to an application of bronopol and an analogue thereof in the preparation of antibacterial drugs, and belongs to the medicine filed. The chemical name of antibacterial is 2-bromo-2-nitro-1,3-propylene glycol, and the chemical name of the analogue of bronopol is 2,2-dibromo-2-nitroethanol. Bronopol and analogue thereof have a very good inhibition activity on bacteria, and drug resistant bacteria, especially multi-drug resistant bacteria, and can be used to treat a plurality of common bacterial infections of livestock and poultry.

Description

technical field [0001] The invention relates to the application of Bropol and its analogues in medicine, which belongs to the field of medicine. Background technique [0002] With the long-term use of a large number of antibacterial drugs in the aquaculture industry, a very severe situation of bacterial drug resistance has been produced. Relevant literature conducted drug resistance experiments on 62 strains of chicken-derived Escherichia coli isolated from six regions in Shanxi Province in the past five years. There is also resistance to drugs that have not been used. The strains resistant to 11-20 kinds of antibacterial drugs accounted for more than 87.1%. The highest drug resistance rate was furazolidone, which accounted for 96.8%, followed by lincomycin, 95.2%, and compound sulfonamide, 93.4%. The resistance rate to ampicillin, penicillin, amoxicillin, erythromycin, streptomycin, enrofloxacin, and doxycycline was 80.6% to 88.7%; to apramycin, nitrofurantoin, sparfloxa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61P31/00A61P31/04
Inventor 李志海张卫红
Owner 李志海
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