3 results about "Geo database" patented technology

The present application relates to a kind of methods based on transcriptome sequencing, machine learning and molecular docking analysis of evodiamine treatment vestibular schwannoma (VS), the present application is analyzed by integrating transcriptome sequencing technology and GEO database, combined with machine learning algorithm, molecular docking and molecular dynamics simulation method, the potential key target and signal pathway of evodiamine treatment VS are systematically analyzed, provide technical support for the mechanism research of evodiamine, and provide reference basis for future individualized treatment strategy of VS.

The invention provides a rural planning method and system of a multi-source data fusion model, and relates to the technical field of rural planning, and the method comprises the steps: constructing a fusion model of a GIS spatial data model, a BIM model and an inclined three-dimensional model, and presenting a to-be-planned rural three-dimensional scene according to the fusion model and a three-dimensional scene graph data structure; planning index measurement, sunlight analysis, height control analysis and underground space analysis are carried out on the to-be-planned rural three-dimensional scene, a plurality of planning schemes are generated, and the planning schemes are visually presented on the to-be-planned rural three-dimensional scene; and feasibility simulation analysis is carried out on the visually presented planning scheme, fine adjustment is carried out on the planning scheme according to the simulation analysis result, and the intuitiveness and interactivity of the planning result are enhanced through three-dimensional scene display.

The invention provides an Alzheimer's disease biomarker and a screening method thereof. The Alzheimer's disease biomarker is a CD44 gene or a protein coded by the CD44 gene. The screening method of the Alzheimer's disease biomarker comprises the following steps: screening differential expression genes of AD patients through a GEO database, obtaining differentially expressed ferroptosis related genes, carrying out protein interaction network analysis on the differential expression genes of the AD patients related to ferroptosis, carrying out Mendel randomization through machine learning, and screening out the differential expression genes of the AD patients related to ferroptosis; and carrying out human plasma RT-qPCR verification on the randomization result, and selecting a gene which is different from the control group in expression level in the RT-qPCR verification as the Alzheimer's disease biomarker. The CD44 is used as the Alzheimer's disease biomarker, the prediction effect is excellent, a new clue is provided for diagnosis and treatment of AD, and a foundation is laid for revealing complex pathogenesis and developing more effective intervention measures.