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AML patient immune typing system, AML patient prognostic scoring model and construction method thereof

A technique for immunophenotyping and construction methods, which is applied to the analysis of two-dimensional or three-dimensional molecular structures, epidemic warning systems, instruments, etc., and can solve problems such as the absence of immune typing models, so as to help guide clinical treatment, Accurate grouping and significant difference in prognosis

Active Publication Date: 2021-06-29
THE SECOND AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV
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Problems solved by technology

Despite the diversification of research methods and results, there is no more optimal model based on immunophenotyping

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  • AML patient immune typing system, AML patient prognostic scoring model and construction method thereof
  • AML patient immune typing system, AML patient prognostic scoring model and construction method thereof
  • AML patient immune typing system, AML patient prognostic scoring model and construction method thereof

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Embodiment Construction

[0024] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail in conjunction with specific embodiments.

[0025] The present invention uses big immune data of AML patients to create the immune typing of AML patients, then builds a new prognosis scoring model for AML patients, and explores effective potential therapeutic targets and drugs for each group of immune typing, providing new basis and basis for precise treatment Strategy.

[0026] The establishment process of the immune typing system of AML patients:

[0027] (1) First, in order to construct the immune big data of AML patients, we collected and downloaded 7 AML-related GEO databases (GSE10358, GSE66525, GSE8970, GSE12417, GSE37642, GSE6891 and GSE71014), with a total of 1799 cases. Among them, 1299 samples had overall survival (OS) data. The basic information of the patients is shown in Table 1. We removed the ...

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Abstract

The invention discloses an AML patient immune typing system, an AML patient prognosis scoring model and a construction method thereof. The construction method of the immune typing system comprises the following steps: 1) collecting immune microenvironment information of an AML patient from a GEO database; 2) carrying out clustering analysis to obtain 10 immune cell types with clinical prognosis significance; 3) clustering the patients into three groups: Cluster1, Cluster2 and Cluster3, the immune score and the microenvironment score of the Cluster1 being the lowest, and the HSC infiltration degree of the Cluster1 being the highest; the immune score and the microenvironment score of the Cluster3 being the highest, and the HSC infiltration degree of the Cluster3 being the lowest; the Cluster2 being between the two groups, so that the establishment of the immune typing system is completed. In addition, an AML patient prognosis model is constructed according to the immune typing system, and the model is higher in precision compared with an existing model.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an immune typing system for AML patients, a prognostic scoring model for AML patients and a construction method thereof. Background technique [0002] Acute myeloid leukemia (AML) is a hematological malignancy caused by the uncontrolled proliferation of bone marrow progenitor cells. It has a high clinical incidence rate, high recurrence rate, and low cure rate. Therefore, it is urgent to find new treatment options. At present, research on the immune microenvironment of AML and the design of new drugs using immune principles has always been a hot spot in basic and clinical research. However, in terms of AML typing, the current AML classification system mainly includes the FAB typing system based on morphology, divided into M0-M7; the WHO typing system based on cytomolecular genetics, divided into AML with RUNX1-RUNX1T1, AML With CBFB-MYH11 and so on. Although the immunological resea...

Claims

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Application Information

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IPC IPC(8): G16B15/30G16H50/20G16H50/30G16H50/80
CPCG16B15/30G16H50/20G16H50/30G16H50/80Y02A90/10
Inventor 曾添晟付林
Owner THE SECOND AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV
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