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Application of apoptosis-related genes in repeated implantation failure

A technology of apoptosis and genes, applied in the fields of biomedicine and molecular biology, can solve the problem of few apoptosis-related genes

Pending Publication Date: 2021-10-29
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are still few studies on the role of apoptosis-related genes in recurrent implantation failure. Therefore, it is necessary to explore more effective markers for the diagnosis and treatment monitoring of recurrent implantation failure, laying a solid foundation for the development of diagnosis, treatment of RIF and related drugs. Base

Method used

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  • Application of apoptosis-related genes in repeated implantation failure
  • Application of apoptosis-related genes in repeated implantation failure
  • Application of apoptosis-related genes in repeated implantation failure

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Experimental program
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Effect test

Embodiment

[0081] 1. Expression and Clinical Cohorts

[0082] GEO database (https: / / www.ncbi.nlm.nih.gov / geo / ): RIF dataset GSE92324, RIF validation set GSE71835.

[0083] Among them, the GSE92324 cohort specimen information:

[0084] 1.1 Inclusion conditions:

[0085] RIF group: 20-40 years old, no previous pregnancy history (primary infertility), at least 2 unsuccessful IVF cycles or at least 2 unsuccessful transfers of high-quality embryos.

[0086] Control group: Fertile egg donors who have undergone COS treatment are the control group, that is, women who have had normal childbirth at least 2 years before enrollment, as fertile healthy egg donors (age 20-40 years old).

[0087] 1.2 Exclusions:

[0088] Patients with polycystic ovary syndrome, endometriosis, abnormal hormone levels, autoimmune diseases, and infertility caused by male factors, while the control group excluded women who received oral contraceptives or any hormone therapy before childbirth or oocyte transplantation ....

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Abstract

The invention provides application of apoptosis-related genes in repeated implantation failure, and belongs to the technical field of biological medicine and molecular biology. According to the application of the apoptosis-related genes in repeated implantation failure, endometrial RNA-seq related data are called from a GEO database, a series of differential genes are screened out from a GSE92324 queue, finally, it is determined that abnormal expression of three apoptosis related genes, namely, CSRNP1, BIRC8 and ELAPOR1 is closely related to repeated implantation failure, verification is carried out through a verification queue (GSE71835), the apoptosis-related genes are proved to have a good diagnostic value for the repeated implantation failure, so that the apoptosis-related genes can be used as prediction and diagnosis markers and potential treatment targets of the repeated implantation failure, plays an important role in diagnosis and treatment of the repeated implantation failure, and has a good practical popularization and application value.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and molecular biology, and specifically relates to the application of apoptosis-related genes in repeated planting failures. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Repeated / recurrent implantation failure (RIF) refers to infertile patients undergoing multiple cycles of in vitro fertilization (IVF) / intra-cytoplasmic sperm injection (ICSI) and transplanted Multiple high-quality embryos without embryo implantation or clinical pregnancy. So far, the molecular mechanism of embryo implantation has not been elucidated. The reasons are complex and involve many aspects, including the follo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/118C12Q2600/136
Inventor 曲迅徐小飞董召刚南兆棣
Owner SHANDONG UNIV QILU HOSPITAL
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