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Evaluation model device for prognosis of esophageal squamous cell carcinoma and modeling method thereof

A technique for esophageal squamous cell carcinoma and prognosis evaluation, applied in the field of medical devices

Pending Publication Date: 2020-08-11
FIRST HOSPITAL OF QINHUANGDAO
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, researchers mostly focus on one or two immune cells to explore their relationship with cancer prognosis, and the established prognosis model also has a large room for improvement

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  • Evaluation model device for prognosis of esophageal squamous cell carcinoma and modeling method thereof
  • Evaluation model device for prognosis of esophageal squamous cell carcinoma and modeling method thereof
  • Evaluation model device for prognosis of esophageal squamous cell carcinoma and modeling method thereof

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Embodiment Construction

[0029] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention.

[0030] refer to Figure 1-4 A prognostic evaluation model device for esophageal squamous cell carcinoma, including a GEO database module, a data acquisition module, a data preprocessing module, a content feature extraction module, a feature variable extraction module, and a prognosis model building module;

[0031] The data acquisition module is used to acquire gene expression data and prognosis data related to esophageal squamous cell carcinoma in the GEO database module;

[0032] The data preprocessing module is used to preprocess the gene expression data and prognosis data related to esophageal squamous cell carcinoma;

[0033] The content feature extraction modu...

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Abstract

The invention discloses an evaluation model device for prognosis of esophageal squamous cell carcinoma and a modeling method thereof. The evaluation model device for prognosis of esophageal squamous cell carcinoma comprises a GEO database module, a data acquisition module, a data preprocessing module, a content feature extraction module, a feature variable extraction module and a prognosis model establishment module, wherein the data acquisition module is used for acquiring gene expression data and prognosis data related to esophageal squamous cell carcinoma in the GEO database module; the data preprocessing module is used for preprocessing the gene expression data and the prognosis data related to esophageal squamous cell carcinoma; and the content feature extraction module is used for extracting content features of the data processed by the data preprocessing module. According to the invention, a tumor infiltration lymphocyte subtype related to survival time can be screened, and a prognosis model is established; and when new feature data exists, the survival time probability of a patient with esophageal squamous cell carcinoma can be obtained only by inputting the values of the feature data into a regression model, so the method has important significance in prognosis of esophageal squamous cell carcinoma.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an esophageal squamous cell carcinoma prognosis evaluation model device and a modeling method thereof. Background technique [0002] Esophageal squamous cell carcinoma (ESCC) is one of the most common cancer types worldwide and a common cause of high cancer-related mortality. Despite advances in diagnostic methods, chemotherapy, radiotherapy, and surgery, ESCC still has high morbidity and mortality, and the prognosis of advanced patients remains poor. The current prognostic assessment of ESCC is mainly based on the TNM staging of the tumor at the time of diagnosis to predict the prognosis. Although TNM staging is a stable and effective prognostic evaluation system, its accuracy needs to be improved in clinical practice. Therefore, a new and more targeted ESCC prognostic evaluation index or model is urgently needed clinically. [0003] Tumor immune microenvironment (TIME) is the ...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16H50/70C12Q1/6886
CPCG16H50/30G16H50/70C12Q1/6886
Inventor 毛羽付占昭董立新张运捷张强
Owner FIRST HOSPITAL OF QINHUANGDAO
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