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Novel screening method for multiple myeloma prognosis gene

A multiple myeloma and gene technology, applied in the direction of instruments, hybridization, data visualization, etc., can solve the problem of the lack of establishment of multiple myeloma prognosis genetic screening methods

Active Publication Date: 2019-09-10
THE FIRST AFFILIATED HOSPITAL OF FUJIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, the heterogeneity of multiple myeloma has been paid more and more attention, however, there is no screening method for multiple myeloma prognosis genes in the world

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  • Novel screening method for multiple myeloma prognosis gene
  • Novel screening method for multiple myeloma prognosis gene
  • Novel screening method for multiple myeloma prognosis gene

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Embodiment Construction

[0039] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is some embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the implementation manners in the present invention, all other implement...

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Abstract

The invention provides a novel screening method for a multiple myeloma prognosis gene based on a gene coexpression network. The method comprises the following steps of S1, acquiring a gene expressionspectrum GSE24080 of an MM patient from a GEO database, preprocessing the gene in the gene expression spectrum GSE24080, and obtaining 5413 genes which have the front 25% highest expression value variances; S2, performing WGCNA gene coexpression network analysis on the 5413 genes for identifying a coexpression functional module; and S3, evaluating correlation between the functional module and clinical information through Pearson related examination, thereby determining a most substantial module.

Description

technical field [0001] The invention relates to a method for screening multiple myeloma prognosis genes based on a gene co-expression network. Background technique [0002] Multiple myeloma (MM) is a malignant plasma cell disease in which tumor cells originate from plasma cells in the bone marrow, which are cells that develop to the final functional stage of B lymphocytes. At present, the heterogeneity of multiple myeloma has been paid more and more attention. However, there is no screening method for multiple myeloma prognostic genes in the world. Contents of the invention [0003] The present invention provides a screening method for multiple myeloma prognosis genes based on gene co-expression network, which can effectively solve the above problems. [0004] The present invention is achieved like this: [0005] A method for screening multiple myeloma prognosis genes based on a gene co-expression network, characterized in that it comprises the following steps: [0006]...

Claims

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Application Information

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IPC IPC(8): G16B35/20G16B45/00G16B25/10G16B50/30
CPCG16B35/20G16B45/00G16B25/10G16B50/30
Inventor 曾志勇陈君敏
Owner THE FIRST AFFILIATED HOSPITAL OF FUJIAN MEDICAL UNIV
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