Aconite extract injection for treating osteoarthritis as well as preparation method and application of aconite extract injection
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A kind of osteoarthritis, extract technology, applied in the field of traditional Chinese medicine production, can solve the problem that the therapeutic effect has not been unanimously recognized, and achieve the effect of no drug dependence, less adverse reactions, and low price
Inactive Publication Date: 2017-12-19
HEILONGJIANG ACAD OF TCM
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Diacerein, glucosamine, chondroitin sulfate and other drugs that improve the condition of OA have given scholars hope to overcome OA, but the therapeutic effect has not been unanimously recognized
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specific Embodiment approach 1
[0041] A preparation method of aconitum extract injection for treating osteoarthritis, comprising the steps of:
[0042] Step 1, taking 75 parts of Aconitum aconitum and 75 parts of Aconitum aconitum respectively as raw materials according to parts by weight, crushing the weighed medicinal materials into coarse powder, and mixing them uniformly for later use;
[0043] Step 2. According to the ratio of 1kg: 10L of medicinal material and solvent, add the uniformly mixed medicinal powder in step 1 into the ethanol solution, stir evenly, and soak in airtight at room temperature for 2 hours, and set aside;
[0044] Step 3, move the mixture in step 2 into a high-pressure reactor for extraction under pressure, and filter and separate the liquid medicine and filter residue after pressure relief;
[0045] Step 4. Add 10 times the volume of water to the filter residue obtained in step 3, mix evenly, move it into a high-pressure reactor for extraction under pressure, and filter to retain...
specific Embodiment approach 2
[0089] A preparation method of aconitum extract injection for treating osteoarthritis, comprising the steps of:
[0090] Step 1, taking 75 parts of Aconitum aconitum and 25 parts of Aconitum aconitum respectively as raw materials according to parts by weight, crushing the weighed medicinal materials into coarse powder, and mixing them uniformly for later use;
[0091] Step 2. According to the ratio of medicinal material to solvent of 1kg:8L, add the medicinal powder mixed uniformly in step 1 into the ethanol solution, stir evenly, and soak in airtight at room temperature for 2 hours, and set aside;
[0092] Step 3, move the mixture in step 2 into a high-pressure reactor for extraction under pressure, and filter and separate the liquid medicine and filter residue after pressure relief;
[0093] Step 4. Add 10 times the volume of water to the filter residue obtained in step 3, mix evenly, move it into a high-pressure reactor for extraction under pressure, and filter to retain th...
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Abstract
The invention discloses an aconite extract injection for treating osteoarthritis as well as a preparation method and application of the aconite extract injection, and belongs to the technical field of traditional Chinese medicine production. The preparation method comprises the steps: weighing radix aconiti and radix aconiti kusnezoffii as raw materials, adding uniformly mixed medicine powder into an alcohol solution, performing sealed soaking, transferring into a high-pressure reaction kettle, performing pressurized extraction, performing depressurization, performing filtering, separating medicine liquid from a filter residue, adding 8-10 volume times of water into the filter residue, performing uniform mixing, transferring into the high-pressure reaction kettle, performing pressurized extraction, concentrating the two medicine liquids until no alcohol odor exists, performing filtering, adding absolute alcohol to allow the alcohol content to reach 75%, performing standing overnight, performing filtering, concentrating the medicine liquid until no alcohol odor exists, performing dilution with injection water to be 10 times, and performing encapsulation and sterilization to obtain the aconite extract injection. The aconite extract injection has the significant influence on MMP-3, ADAMTS, IL-1 beta, IL-18, TNF-alpha and the like, and is confirmed to have a protective effect on chondrocyte damage caused by arthritis.
Description
technical field [0001] The invention belongs to the technical field of traditional Chinese medicine production, and in particular relates to an aconitum extract injection for treating osteoarthritis, a preparation method and application thereof. Background technique [0002] Osteoarthritis (OA) is the degeneration of articular cartilage and the formation of osteophytes at the joint margins caused by many factors such as old age, trauma, joint deformity, and congenital abnormalities of the joints. Clinically, it can lead to joint pain, swelling, and even limited mobility and joint deformities (X-shaped legs or O-shaped legs). According to the statistics of the World Health Organization, the incidence rate of patients with osteoarthritis is more than half of the population over 50 years old in the world, and China alone accounts for 10%. In 2011, the Chinese Rheumatology Association conducted a survey and pointed out that by 2017, the number of patients with osteoarthritis in...
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