Method and system for obtaining four-dimensional blood vessel deformation behavior and in-vivo stress of blood vessel wall

A vascular wall and blood vessel technology, applied in the field of non-invasive calculation, accuracy and speed, can solve the problems of inability to obtain the real-time changes of the mechanical properties of the arterial wall during the cardiac cycle, and the inability to accurately characterize the mechanical properties of the arterial wall.

Active Publication Date: 2017-04-19
SHANGHAI JIAO TONG UNIV +1
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  • Claims
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Problems solved by technology

However, the traditional in vitro stretching experiment has the following limitations: 1) There are certain differences between the in vitro experiment and the mechanical properties of human arterial walls in vivo; 2) Simple stretching experiments cannot obtain complex The mechanical properties of the arterial wall under the stress state and the real-time changes in the cardiac cycle; 3) The average pro

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  • Method and system for obtaining four-dimensional blood vessel deformation behavior and in-vivo stress of blood vessel wall
  • Method and system for obtaining four-dimensional blood vessel deformation behavior and in-vivo stress of blood vessel wall
  • Method and system for obtaining four-dimensional blood vessel deformation behavior and in-vivo stress of blood vessel wall

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Embodiment 1

[0051] In order to further understand the present invention, the present invention will be further elaborated and illustrated below in conjunction with the accompanying drawings and embodiments. figure 1 It is the technical roadmap of the present invention. In a specific embodiment, the method can be summarized as: perform morphological three-dimensional reconstruction on angiographic X-ray time-series images at several time points in the cardiac cycle to obtain several geometric configurations; Discretize the structured grid for each geometric configuration to obtain several point cloud models with the same arrangement structure; according to the principle of global optimization, the principle of minimum distance between nodes is carried out on the front and back adjacent models to achieve a one-to-one correspondence; The global finite element is smoothed by the Laplace method and the difference in space coordinates is used as the displacement field function; the explicit dyna...

Embodiment 2

[0081] In another specific embodiment, using the method for obtaining a displacement field according to the present invention can be achieved through the following steps:

[0082] (1), obtain configuration files of two adjacent time points;

[0083] (2), in step (1), carry out space coordinate difference to all grid points of front and rear adjacent configurations, and use it as the displacement field function from the previous configuration to the latter configuration. The specific calculation process is implemented using Matlab command statements, as follows:

[0084] data1=textread('*.txt'); % read the previous configuration node coordinate file

[0085] data2=textread('*.txt'); % read the coordinate file of the next configuration node

[0086] % Pay attention to the sequence of data1 and data2.

[0087] DisLD=(data2-data1); % difference between front and rear configuration coordinates

[0088] [r,c] = size(DisLD);

[0089] ND_id = data1(:,1);

[0090] OutputFile=fope...

Embodiment 3

[0100] In another specific embodiment, the method of the present invention is used to calculate the right circumflex artery of the human heart. Specifically, this method can be implemented through the following steps:

[0101] (1) Select the right circumflex branch of the heart as the vessel of interest, and take the proximal bifurcation and the distal bifurcation as anatomical landmarks;

[0102] (2), step (1) in the X-ray contrast time series, select 3 moments, carry out three-dimensional reconstruction to obtain 3 vascular wall anatomical shape models, including the end diastole, the middle moment of the systole, and the end systole;

[0103] (3), the three geometric configurations in step (2) are all discretized into three point cloud structure models in the space physical domain, with 296 layers in the vertical direction and 32 layers in the circumferential direction, and the total number of points obtained is 9472;

[0104] (4), with the three point cloud structures in ...

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Abstract

The invention provides a method and a system for obtaining a four-dimensional blood vessel deformation behavior and in-vivo stress of a blood vessel wall. The method combines a three-dimensional image reconstruction technology and a discrete approximation theory to realize the big deformation behavior and the in-vivo stress of the blood vessel wall. The innovations of the invention are that the change of an anatomic form of healthy or pathological vessels in a cardiac cycle along with the time can be intuitively researched for a stent to intervene pre-operation evaluation and selection of a treatment strategy; a change condition of the in-vivo stress distribution of the blood vessel wall can be also provided for plaque rupture prediction and diagnosis, so that a new method is provided for quantitative description of kinematics characteristics of the blood vessel wall and the in-vivo stress of the blood vessel wall.

Description

technical field [0001] The invention relates to the application in the medical field, in particular to the accurate, fast and non-invasive calculation of the four-dimensional blood vessel deformation behavior and the in-body stress of the vessel wall based on images. Background technique [0002] In-body stress is the stress state of living organisms in a specific mechanical environment. When the in-body stress exceeds the tolerance range of the normal living body, the normal living body changes the mechanical properties of its own tissues to adapt to the current stress state, thus compensatory tissue lesions occur. The heart contracts and relaxes continuously, resulting in periodic changes in the anatomical shape of the cardiovascular wall and the in-body stress of the wall. Quantitative description of the deformation behavior and in vivo stress of the cardiovascular wall will help to understand the kinematic characteristics and biomechanical properties of the cardiovascul...

Claims

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Application Information

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IPC IPC(8): G06F19/00G06T17/00
CPCG06F19/321G06T17/00G16H50/20
Inventor 涂圣贤吴信雷徐波
Owner SHANGHAI JIAO TONG UNIV
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