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Oral micro-emulsion composition of silybin

A technology of silymarin and microemulsion, which is applied in the directions of drug combination, emulsion delivery, plant raw materials, etc., can solve the problems of limited bioavailability of silymarin, complicated preparation method, etc.

Inactive Publication Date: 2001-10-10
HANMI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of the above preparations are very complicated, and the in vivo bioavailability of silymarin is still very limited

Method used

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  • Oral micro-emulsion composition of silybin
  • Oral micro-emulsion composition of silybin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Quantity (mg / capsule)

[0042] Evenly mix and dissolve Carduus marianus extract and dimethyl isosorbide, and then add other components and dissolve them. Next, the resulting mixture is filled in soft capsules, which are prepared by conventional methods using succinic acid, gelatin, glycerin, and pure water. Example 2: Preparation of soft capsules

Embodiment 2

[0043] Quantity (mg / capsule)

[0044] Quantity (mg / capsule)

[0045] Quantity (mg / capsule)

[0046] Quantity (mg / capsule)

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PUM

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Abstract

An oral micro-emulsion composition comprising a Carduus marianus extract, silybin or a silybin derivative; an organic solvent; a surfactant; and an oil provides a high in vivo bioavailability of silybin.

Description

Invention field [0001] The present invention relates to an oral silybin composition with higher bioavailability of silybin, and more specifically to a microemulsion composition containing Carduus marianus extract or silybin. Background of the invention [0002] Silymarin is the main component of Carduus marianus extract, and it is known to have a very excellent protective effect on liver cells from smoking, drinking, overwork, environmental pollution, stress or liver damage drugs. However, due to the low solubility of silymarin in water, its oral administration bioavailability is very low. [0003] Korean Patent Application No. 96-13361 describes a method for increasing the solubility of silymarin, in which silymarin is dissolved in a mixture of polyethylene glycol and ethanol, and then the resulting solution is added to an aqueous polysorbate solution to prepare a silymarin solution. However, the disadvantage of this method is that the increase in solubility of silymarin is only...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61K9/107A61K31/357A61K36/28A61K47/10A61K47/12A61K47/16A61K47/20A61K47/22A61K47/24A61K47/28A61K47/34A61K47/44A61P1/16
CPCA61K36/28A61K9/1075Y10S514/937Y10S514/893A61P1/16A61K36/19
Inventor 禹钟守徐贤珠
Owner HANMI PHARMA
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