12 results about "Salicin" patented technology

This application relates to the field of traditional Chinese medicine technology, specifically to a method for preparing and detecting willow twig extract and its preparations. The preparation method specifically includes the following steps: (1) Willow twig slices are decocted twice with water, filtered, and the filtrates are cooled to room temperature and then combined to obtain the willow twig extract; (2) The decoction is concentrated under reduced pressure and low temperature to obtain an extract extract with a yield of 3.8%~7.0%; the extract extract is obtained; (3) The extract is prepared into the desired dosage form. This application selects salicin as the indicator component of willow twig extract and its preparations, and conducts a quantitative determination method of ultra-high performance liquid chromatography for the content determination of willow twig extract and its preparations, and formulates quantitative standards for willow twig extract and its preparations, providing a scientific basis for the establishment of quality standards for willow twig extract and its preparations. A characteristic spectrum of willow twig medicinal materials is established, and a material basis study is conducted, and the chemical components corresponding to the characteristic peaks are identified.

The application provides a composition containing salicin, a product and application thereof, and relates to the technical field of cosmetics. Specifically, the application provides application of salicin in promoting intracellular melanin synthesis, and it is first proved that salicin can promote intracellular melanin synthesis by promoting tyrosinase activity, thereby providing a new functional ingredient for enhancing intracellular melanin synthesis, and preparing a product for improving and treating white hair and vitiligo.

The invention relates to a quinic acid salicin ester derivative extracted from shiny feet, a method and application. The quinic acid salicin ester derivative is at least one of a compound 1 and a compound 2. The compound 1 and the compound 2 can be used for preparing medicines or products for preventing or treating myocardial hypertrophy diseases; and when the concentration of the compound 1 and the compound 2 is less than 50 [mu] mol / L, the compound 1 and the compound 2 have no obvious toxicity to cells and show higher biological safety. The invention provides a new choice for development of a cardiac hypertrophy inhibitor.

The invention discloses a method for synthesizing salicylic acid and derivatives thereof by multi-enzyme cascade catalysis of phenol, which comprises the following steps: reacting a reaction system containing phenol, enzyme, metal ion salt and bicarbonate to obtain salicylic acid and derivatives thereof; when the enzyme is carboxylase, the reaction system reacts to obtain salicylic acid; when the enzyme is a combination of carboxylase, carboxylate reductase, formate dehydrogenase and phosphokinase, the reaction system reacts to obtain salicylaldehyde; when the enzyme is a combination of carboxylase, carboxylate reductase, formate dehydrogenase, phosphokinase and alcohol dehydrogenase, the reaction system reacts to obtain salicyl alcohol; when the enzyme is a combination of carboxylase, carboxylate reductase, formate dehydrogenase, phosphokinase, alcohol dehydrogenase and glycosyltransferase, the reaction system reacts to obtain salicin. According to the method, a green synthesis path based on biological catalysis is utilized, phenol is converted into chemicals with higher economic value, and environmental pollution and carbon emission are reduced.

The invention belongs to the technical field of soil chemical analysis, and relates to a method for determining intracellular beta-glucosidase in acid soil, which comprises the following steps: 1) preparing a reagent for a chloroform fumigation method, a reagent for a salicin colorimetric method and a phosphate buffer solution; 2) pre-culturing the soil sample to be tested; 3) dividing the test soil samples into a fumigation group and a non-fumigation group, and performing chloroform fumigation treatment on the fumigation group; 4) respectively adding a phosphate buffer solution and a salicin colorimetric method reagent into the test soil sample in the unfumigated group and the test soil sample subjected to chloroform fumigation treatment, and culturing; (5) respectively measuring the light absorption values of the test soil sample of the non-fumigated group and the test soil sample of the fumigated group at 510nm of the spectrophotometer and the salicin concentration of the test soil sample; 6) calculating the intracellular beta-glucosidase based on the salicyl alcohol concentration. The method for determining the intracellular beta-glucosidase in the acid soil, provided by the invention, is convenient to operate, high in accuracy and high in feasibility.

The invention relates to the field of salicin production, and discloses a low-temperature alkalization extraction method of salicin from white willow bark, which comprises the following steps: S1, firstly, adopting local white willow in Longnan of Gansu Province, stripping the bark and trunk of the white willow by workers, and then drying in the shade; s2, selecting the white willow barks dried in the shade in the step S1, and crushing the white willow barks dried in the shade by using crushing equipment; and S3, adding the white willow barks crushed in the step S2 into a stirrer, and then adding water which is equal to 100-200% of the crushed white willow barks and quick lime which is equal to 13-26% of the crushed white willow barks. Through the efficient low-temperature extraction method, the accumulation alkalization temperature is controlled to be 15-25 DEG C, mild heat release of the reaction of quick lime and water is utilized, the salicin is prevented from being decomposed at high temperature, meanwhile, dissolution of glycoside components is promoted through the alkaline environment with the pH being 10-12, and the low-temperature extraction efficiency and effect are further improved.

The invention belongs to the technical field of medicines, and particularly relates to application of salicin in preparation of a preparation for preventing and / or treating bone marrow adipogenesis related diseases. The invention provides an application of salicin in preparation of a preparation for preventing and / or treating bone marrow adipogenesis related diseases. The bone marrow adipogenesis related diseases comprise osteoporosis. Research finds that salicin with a proper dose specifically blocks adipogenic differentiation of mesenchymal stem cells by inhibiting apoptosis of the mesenchymal stem cells and PI3K / AKT signal channels, and reduces BMAT accumulation to recover bone metabolism balance, so that bone marrow lipid metabolism can be effectively regulated, bone marrow adipogenesis related diseases such as osteoporosis can be prevented and / or treated, and the bone marrow adipogenesis related diseases can be prevented and / or treated. BMAT accumulation is reduced to restore bone metabolic balance.

The invention provides a detection method for simultaneously determining seven active components in cosmetics, constructs a high performance liquid chromatography determination method which is efficient, accurate and simple to operate, and can simultaneously detect the contents of Ectoin, hydroxytyrosol, oleuropein, bisabolol, gentiopicroside, salicin and madecassoside in the cosmetics, so that the contents of Ectoin, hydroxytyrosol, oleuropein, bisabolol, gentiopicroside, salicin and madecassoside in the cosmetics can be detected at the same time. And the method is applied to detection of large-batch cosmetics and provides technical support for product quality control in the cosmetic industry.

The present disclosure provides pharmaceutical compositions comprising a microorganism capable of expressing one or more enzymes that convert salicin to saligenin, and salicin, or a pharmaceutically acceptable salt thereof. The present disclosure also provides methods for treating an inflammatory bowel disease (IBD) in a subject in need thereof comprising administering to the subject a therapeutically effective amount of any of the pharmaceutical compositions described herein. Methods for treating an inflammatory bowel disease (IBD) in a subject in need thereof comprising administering a therapeutically effective amount of a pharmaceutical composition comprising saligenin, or pharmaceutically acceptable salt thereof, are also provided herein. The present disclosure further provides kits, food products, nutraceuticals, and bacterial cells.

The invention discloses thermophilic beta-1, 4-glucosidase and an application of the thermophilic beta-1, 4-glucosidase. The amino acid sequence of the thermophilic beta-1, 4-glucosidase is as shown in SEQ ID NO: 1. The thermophilic beta-glucosidase provided by the invention can be used for hydrolyzing p-nitrophenyl-beta-D glucopyranoside (pNPGlu), p-nitrophenyl-beta-D galactopyranoside (pNPGal), p-nitrophenyl-beta-D xylopyranoside (pNPXyl), p-nitrophenyl-alpha-D glucopyranoside (pNP alpha Glu), p-nitrophenyl-N-acetylglucosamine, geniposide, polydatin, glucosyltransferase, glucosyltransferase and the like. And salicin and arbutin. The optimum reaction temperature of the enzyme is 90 DEG C, and after the enzyme is treated at 70 DEG C for 48 hours, the residual enzyme activity is greater than 95%, so that the industrial application of preparing the blue pigment by adopting a one-pot method under a high-temperature condition is facilitated.

The invention discloses an azelaic acid composite micelle composition as well as a preparation method and application thereof. The composition comprises the following components: azelaic acid, a component A, a component B and a pH regulator, the mass ratio of the azelaic acid to the component A to the component B is (0.5-6): (0.5-2): 1. When the azelaic acid composite micelle composition disclosed by the invention is in contact with skin, electrolyte in the skin can neutralize charges of shells of micelles, weaken electrostatic repulsion among the micelles and initiate micelle aggregation, the extrusion effect of the micelles in the aggregation process is enhanced, hydrophobic cores of part of micelle structures are broken, and thus the skin is protected. Meanwhile, beta-glucosidase in the skin can catalyze salicin in the component B in the micelle structure to be hydrolyzed into salicylic acid, and the salicylic acid and the azelaic acid cooperate with each other to jointly achieve the anti-inflammatory and oil-control effects.