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Composition for promoting production of type I collagen and/or elastin

A technology of collagen and elastin, which is applied in the direction of drug combination, food science, plant raw materials, etc., can solve the problems of insufficient efficacy, safety problems, skin irritation, etc., to improve skin tension and elasticity, and high safety Sexuality, the effect of preventing skin aging

Inactive Publication Date: 2006-04-19
FUAN KERU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, ingredients that can promote the production of type I collagen and elastin include retinoic acid or its derivative retinol (retinol) (non-patent literature 2 and 3), but because of its irritation to the skin, it is Security is problematic (Non-Patent Document 4), and it is generally not put into practical use due to its poor stability
[0006] Therefore, although a composition that can increase the amount of dermal collagen and elastin has been developed, due to the need to take into account the safety of the skin, it still cannot achieve sufficient effectiveness

Method used

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  • Composition for promoting production of type I collagen and/or elastin
  • Composition for promoting production of type I collagen and/or elastin
  • Composition for promoting production of type I collagen and/or elastin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] cream

[0164] The cream was manufactured according to the following prescription (unit: weight %).

[0165] (1) Stearyl Alcohol 6.0

[0166] (2) Stearic Acid 2.0

[0167] (3) Hydrogenated Lanolin 4.0

[0168] (4) Squalane 9.0

[0169] (5) Octyl Dodecanol 10.0

[0170] (6)POE(25)Cetyl Alcohol Ether (POE(25)Cetyl Alcohol Ether) 3.0

[0171] (7) Glycerin Monostearate 2.0

[0172] (8) Silymarin 0.1

[0173] (9) Appropriate amount of preservative

[0174] (10) Appropriate amount of spices (Armoatics)

[0175] (11) 1,3-Butanediol (1,3-Butylene Glycol) 6.0

[0176] (12) PEGl500 4.0

[0177] (13) Balance of purified water (DI Water)

[0178] Manufacturing method:

[0179] The above-mentioned components (1) to (10) were heated and dissolved at 80° C. to form an oil phase. Components (11) to (13) were heated and dissolved at 70° C. to form an aqueous phase. Slowly add the water phase to the oil phase to emulsify, while stirring to 40°C and cool, then stir and cool...

Embodiment 2

[0180] lozenge

[0181] Tablets were manufactured according to the following prescription (unit: weight %).

[0182] (1) Silymarin 20.0

[0183] (2) Lactose 65.0

[0184] (3) soybean powder 14.0

[0185] (4) Guar Gum 1.0

Embodiment 3

[0186] Emulsion

[0187] The emulsion was prepared according to the following formulation (unit: weight %).

[0188] (1) Dipropylene Glycol 9.000

[0189] (2) Milk thistle with 70% silymarin 1.000

[0190] (3) (Hydroxyethyl Acrylic Acid / Propylene Dimethyl Taurine Na) Copolymer Hydroxyethyl Acrylate 0.188

[0191] Acryldimethyl Taurin Na

[0192] (4) Squalane 0.127

[0193] (5) Polysorbate 60 Polysorbat 60 0.028

[0194] (6) Lauryl Glutamate (Phytosterol / OCTYLDODECYL) Phytosteryl / octyldodecyl 1.000

[0195] lauroyl glutamate

[0196](7) Glycerin 5.000

[0197] (8) Dimethicone 3.000

[0198] (9) Refined water 74.742

[0199] (10)Carbomer 0.200

[0200] (11) Betaine 2.000

[0201] (12) Ethanol 3.000

[0202] (13) Potassium Hydroxide 0.065

[0203] (14) Refined water DI water 0.650

[0204] (Manufacturing method) The above-mentioned component (1) was added to (2) and di...

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PUM

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Abstract

It is intended to provide a composition promoting the production of type I collagen and / or elastin in human skin fibroblasts to thereby provide a composition for preventing the skin from aging which can improve skin tension and elasticity, is sufficiently efficacious in preventing, inhibiting or relieving wrinkles and sagging in the skin and yet has a high safety to the skin. A composition characterized by containing silymarins, (i.e., a general term for flavonolignans such as silybin, silydianin, silychristin and siosilybin) and having an effect of promoting the production of type I collagen and / or elastin; and a composition characterized in that silymarins contained therein originate from a silymarin-containing plant and / or an extract of the plant and having an effect of promoting the production of type I collagen and / or elastin.

Description

technical field [0001] The present invention relates to a composition having a promoting effect on type I collagen and / or elastin produced by human skin dermal fibroblasts (hereinafter referred to as "skin fibroblasts"). In particular, the present invention relates to a composition capable of improving the tension and elasticity of the dermis, and having the effect of preventing, preventing, and improving skin aging such as wrinkles or sagging caused by aging and ultraviolet radiation. Background technique [0002] The changes that occur with skin aging, such as wrinkles or sagging, are generally believed to be related to environmental stress and mental stress such as aging and sun exposure. As the skin ages, the epidermal cells and fibroblasts that make up the skin tissue gradually decrease, and at the same time, the blood vessels that supply the substances necessary for the activities of these cells also decrease. Changes in the extracellular matrix (Extracellular Matrix)...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04A61K8/49A61Q19/08A61K36/00A61K31/357A61P17/00A23L1/30A61K8/97A61K36/28
CPCA61Q19/08A61K31/357A61K36/28A61K8/97A61K2800/70A23L1/3002A23L33/105A61K8/9789A61P17/00A61P17/16A61P43/00A61K8/49
Inventor 宫田智繁田叶子樱井哲人
Owner FUAN KERU
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