279 results about "Silybum marianum" patented technology

Disclosed are compositions and methods for their use comprising effective amount of Silybum marianum extract and Momordica grosvenori fruit extract.

The invention provides a production method of silymarin, which comprises the following steps: shelling silybum marianum seeds; filling the silybum marianum shells into a softening tank, and softening the silybum marianum shells with vapor; filling the softened silybum marianum shells into a flat-turn extractor, and adding ethanol to carry out extraction, thereby obtaining an extracting solution; concentrating the extracting solution to a certain degree to obtain a concentrated solution; adding aqueous alkali into the concentrated solution, stirring and standing to precipitate; and filtering the precipitate, drying, pulverizing and screening. In the extraction process, no toxic or harmful reagent is adopted, and no solvent residue which is harmful to the product can be produced; the ultraviolet detection indicates that the total flavone content in the product can be higher than 70%, the contents of silybin and isosilybin can be higher than 30%, and the product yield is 3-4% of the silybum marianum seeds; and therefore, the invention has the advantages of high extraction efficiency, simple technique and low solvent consumption.

The invention relates to a novel process for the isolation of a hepatoprotective agent Silymarin from the seeds of the plant Silybum marianum comprising (i) Precooling the seeds to (-) 20° C. for 24 hours in a deep freezer/cold room. (ii) Powdering the cooled seeds in a hammer mill, fitted with about 40 mesh discharge screen. (iii) Defatting the seeds by extracting with hexane in a soxhlet type extractor to remove the total quantity of fatty oil without using a scrain. (iv) Extracting the defatted seeds with acetonitrile at 20-30° C. to extract silymarin fraction. (v) Concentration of the sensitive silymarin fraction under vacuum in a agitated wiped thin film evaporator (vi) stirring the silymarin such dry powder with cold dichloromethane at 5° C. followed by filtration and drying with a slow purge of nitrogen gas. (vii) Further purification of silymarin by suspending in 5 times its weight of acetonitrile and precipitating by 8-12 times its weight of water at 20° C. (viii) Filtering the precipitated silymarin in a closed vacuum filter and having 1-2 mum screen washing the cake three times with distilled water (ix) Drying of Silymarin cake in vacuum oven to obtain substantially pure silymarin.

The invention relates to a Chinese medicinal composition for treating jaundice, which consists of the following Chinese medicinal raw materials in parts by weight: 30 to 50 parts of oriental wormwood, 10 to 20 parts of cape jasmine, 10 to 20 parts of dendrobe, 10 to 20 parts of radix curcumae, 10 to 20 parts of gizzard-membrane, 10 to 30 parts of roasted bighead atractylodes rhizome, 20 to 40 parts of coix seed, 10 to 20 parts of Chinese angelica, 10 to 20 parts of red-rooted salvia root, 5 to 15 parts of Chinese rhubarb, 20 to 40 parts of roasted malt, 20 to 40 parts of longhairy antenoron herb, 5 to 15 parts of giant knot weed, 10 to 20 parts of sedum sarmentosum, 10 to 20 parts of abrus cantoniensis hance, 3 to 9 parts of liquorice, 30 to 50 parts of red peony root, 10 to 30 parts of white peony root, and 20 to 40 parts of silybum marianum. The Chinese medicinal composition has the functions of clearing heat and promoting diuresis, soothing liver and reducing heat, invigorating spleen and supplementing qi, and relieving jaundice symptom, has the advantages of remarkable curative effect and reliable effect in treating jaundice, is wide in medicinal component source and easy to prepare, and does not have toxic or side effect.

The invention discloses a production method for simultaneously extracting silybum marianum oil and silymarin from a silybum marianum cake. The method comprises the following steps: (a) performing multistage pulse counter-current extraction on the silybum marianum cake to obtain a mixed solution containing the silybum marianum oil and the silymarin, wherein the solvent used in the extracting process is a mixed solvent of the methanol and the normal hexane at a mass ratio of (0.6-1):1; (b) filtering and separating the mixed solution containing the silybum marianum oil and the silymarin to obtain the silybum marianum oil normal hexane mixed solution and the silymarin methanol mixed solution; (c) performing negative-pressure counter-current film evaporation and negative-pressure water vapor steam distillation on the silybum marianum oil normal hexane mixed solution to obtain the silybum marianum oil; and (d) performing negative-pressure climbing film evaporation, negative-pressure rectification and spray dehydration on the silymarin methanol mixed solution to obtain the silymarin. By adopting the method provided by the invention, the extracting rate of the silymarin is greatly increased and the problems of large input of the solvent and low extracting rate in the silymarin production process can be solved; the production process is free of pollution and low in cost, so that the large-scale, industrial and continuous production of the silymarin can be realized.

The invention relates to a method for preparing Silymarin. The method has the advantages that the operation is simple and convenient, the pollution is low and the equipment investment is small. The technological steps are that: Silybum marianum fine powder is taken and is added in a CO2 supercritical extractor, methanol is used as entrainer, the entrainer accounts for 2-6 percent of the total volume of extraction solvent, the extraction pressure is 10-40MPa, the extraction temperature is 30-60 DEG C, CO2 flow is 1-5ml per gram crude drug per minutes, the extraction time is 150-250min, the extract is obtained, acetone is added, agitation is conducted to enable the acetone to be dissolved, filtration is conducted, the filtered liquid is obtained and is concentrated, the obtain liquid is filled in a high-efficiency countercurrent extractor, water-acetone-chloroform (1:5:2) solvent system is used, the bottom phase is a fixed phase, the top phase is a flowing phase, Silymarin segments are collected and are concentrated, crystals are precipitated and are separated, and acetone-petroleum ether (0.5-2:1) are added for recrystallization. The invention has the advantages that the purity of the prepared Silymarin is high and the industrialization amplification can be realized easily.

Disclosed is a composition and methods for its use capable of treating pruritus comprising a combination of one or more of an Echinacea purpurea extract, a Silybum marianum extract, glycerin, and a mixture comprising cetylhydroxyproline palmitamide/steric acid/Brassica campestris (rapeseed) sterols.

Disclosed is a cleansing composition and methods for its use capable of treating acne comprising an anti-acne agent comprising benzoyl peroxide, a combination of cleansing agents comprising disodium laureth sulfosuccinate and sodium C14-16 olefin sulfonate, and a combination of skin active ingredients comprising Cucurbita pepo fruit extract, niacinamide, epilobium angustifolium extract, Silybum marianum fruit extract, and Lactobacillus/ganoderma lucidum extract/Lentinus edodes extract ferment filtrate.

An antioxidant-promoting composition that increases antioxidant defense potential in a subject is disclosed. The composition contains Bacopa monniera extract comprising a Bacopa monniera active ingredient; a Silybum marianum (milk thistle) extract comprising a Silybum marianum active ingredient; a Withania somnifera (ashwagandha) extract comprising a Withania somnifera active ingredient; aCamellia sinensis (green tea) extract comprising a Camellia sinensis active ingredient; a Curcuma longa (turmeric) extract comprising at least one Curcuma longa active ingredient, and optionally a Centella asiatica (Gotu kola) extract; a Ginko biloba extract; an Aloe vera extract; and N-acetyl cysteine. The process for quantifying Nrf2 transcription factor activating potential of the botanical extracts comprising the botanical active ingredients is described.

Disclosed is a topical skin cleanser comprising Silybum marianum fruit extract, Momordica grosvenorii fruit extract, and a cosmetic vehicle comprising at least 50% by weight of the composition of water and disodium EDTA, glycerin, phenoxyethanol, triethanolamine, 3-Iodo-2-propynyl butyl carbamate, and benzyl alcohol.

The invention discloses water-soluble silymarin, which is an inclusion compound that takes cyclodextrin as main molecules and silymarin as guest molecules; and the inclusion compound contains 12 to 20wt % of silybinin. The preparation method thereof comprises the following steps: silybum marianum seeds are squeezed into silybum marianum cakes; the silybum marianum cakes are added into alkali water ethanol solution and are heated to 75DEG C to 85DEG C, the constant temperature is kept for 1.5-2.5 hours, and silybum marianum extracting solution is prepared after 2-4 times of continuous extraction; the silybum marianum extracting solution is added with the cyclodextrin for inclusion, thus obtaining inclusion compound solution; flocculant is added, standing after being well stirred; after flocculate is filtered out, membrane separation process is carried out, thus obtaining water-soluble silymarin solution; and after the membrane separation process, the water-soluble silymarin solution is concentrated and dried, thus obtaining the dried product of the water-soluble silymarin. The water-soluble silymarin prepared by the method has the advantages of high solubility, good quality, good drug stability and high bioavailability.

The invention provides a method for extracting silymarin from milk thistle seed coat. The objective of the invention is to solve the following problem in the prior art: the extraction of silymarin from milk thistle exotesta uses the integral body of milk thistle as the raw material, and therefore the extracted coarse silymarin contains considerable impurities and has to be refined; the process of refinement is cumbersome and consumes considerable organic solvents. The method provided in the invention comprises the following steps: cleaning milk thistle seeds; decorticating the milk thistle seeds with a decorticator so as to obtain milk thistle seed coats and seed kernels respectively; carrying out extraction on the milk thistle seed coats with a solvent; recovering the solvent by condensation so as to obtain silymarin. According to the invention, silymarin extracted from milk thistle seed coats has a quality far surpassing the international standard.

The invention relates to micropterus salmonides compound feed and a preparation method thereof and belongs to the technical field of feed processing. The compound feed is prepared from the following components in parts by weight: 300-400 parts of fish meal, 200-300 parts of soybean meal, 100-250 parts of peanut meal, 200-250 parts of refined flour, 15-20 parts of monocalcium phosphate, 3-5 parts of choline chloride, 8-10 parts of a mineral substance premix, 2-4 parts of a vitamin premix, 1.5-2.5 parts of spiral seaweeds, 0.8-1.2 parts of silybum marianum and 0.8-1.2 parts of curcumin. The preparation method comprises the following steps: crushing the fish meal, the soybean meal and the peanut meal and sieving, and uniformly mixing with residual raw materials; then crushing and sieving the mixture in an ultrafine crusher; and after blending and granulating, drying, cooling, packaging and bagging to prepare the micropterus salmonides compound feed. With the adoption of the compound feed, the immunological competence of micropterus salmonides can be effectively improved and a physiological metabolism problem of the micropterus salmonides is solved; fatty livers are prevented so that the survival rate is improved; the feed can completely replace frozen and fresh seafood and can be used for feeding and culturing in a whole process, so that the pollution to a water body environment, caused by the fact that the frozen and fresh seafood is used for culturing, is solved; and the micropterus salmonides compound feed has relatively high economic benefits and remarkable social benefits.

The invention discloses a method for extracting silybum marianum protein and belongs to the technical field of application of biotechnology in foods. The method comprises the following steps: dissolving silybum marianum seed kenel spent meal in distilled water, adding mixed enzyme of cellulose and amylase according to a mass ratio of the enzyme to the substrate of 4.5-12 percent so as to carry out enzymolysis for 0.5-3 hours under the conditions of the pH of 4-7 and the temperature of 40-70 DEG C, heating and inactivating the enzymes, regulating the pH value of the solution to be 10 at the water bath temperature of 50 DEG C, leaching for 60 minutes, centrifuging, regulating the pH value of the liquid supernatant to be 5.5 by using hydrochloric acid, centrifuging and collecting the precipitate, dissolving the precipitate by using water, regulating the pH to be neutral, and performing vacuum freeze drying to obtain the silybum marianum protein powder. The silybum marianum seed kenel spent meal is treated by employing cellulose and amylase, and the cellulose and amylase can hydrolyze cellulose, starch and other polysaccharide components, so that the constraint of the polysaccharide on the protein can be relieved, the dissolution of the protein is promoted, and the protein extracting rate is improved.

The invention discloses a novel preparation method and a use of silybin diethylene glycol succinate and salts thereof. The preparation method can be realized through the following technique that: silybin reacts with butanedioic anhydride in an appropriate organic solvent to synthesize silybin succinic acid monomethyl ester, and then the silybin succinic acid monomethyl ester reacts with sodium hydroxide in a specific medium to generate florfenicol succinic acid ester sodium salt. The preparation method mainly overcomes the disadvantages that the prior synthetic method is unstable to heat and alkali, easy to produce a series of side reactions to affect the purity and quality of products, fussy and complex to operate. The novel method is simple, stable, high in yield and suitable for industrial mass production. Meanwhile, the novel method increases the solubility of the silybin and improves the problem of low bioavailability, thereby developing the effect of protecting liver and providing theoretical basis for clinical use.

The invention relates to a method for extracting milk thistle oil from milk thistle seeds, belonging to the extraction technology of milk thistle oil, comprising the following steps: (1) selecting milk thistle seed powder as a raw material, and conducting physical properties by alcohol After granulation, mix a certain amount of filler, the mixing ratio is milk thistle seed powder:filler=10:1, (2) the mixed raw material is filled in the extraction kettle, and supercritical CO2 fluid and carrier are introduced , control the extraction pressure and temperature for extraction, (3) control the primary and secondary separation temperature and pressure for separation, (4) control the temperature and pressure of the rectification column for supercritical CO2 rectification to remove impurities and water. The milk thistle oil prepared by the method of the invention is clear and translucent, with high extraction rate and high quality.

The invention discloses a medicine for treating primary hepatic carcinoma. The medicine is prepared from the following medicinal raw materials: codonopsis pilosula, astragalus membranaceus, human placenta, radix paeoniae alba, fructus lycii, radix bupleuri, fingered citron, silybum marianum, lysimachia christinae hance, corn stigma, pericarpium citri reticulatae, rhizoma atractylodis macrocephalae, fructus aurantii, angelica sinensis, corydalis tuber, safflower carthamus, salviae miltiorrhizae, turtle shell, oldenlandia diffusa, sculellaria barbata, selfheal, dandelion, edible tulip, pericarpium citri reticulatae viride, kelp, myrrh and licorice root. The medicine is prepared from a prescription of pure traditional Chinese medicinal materials, has small toxic and side effect, and can be used for improving the living quality of patients with primary hepatic carcinoma in middle and advanced stage to prolong the lives of patients and curing early primary hepatic carcinoma. The total effective rate of the medicine for treating primary hepatic carcinoma is 100 percent.

The invention discloses a medicine for treating gallstones. The medicine consists of the following Chinese herbal medicinal raw materials in parts by weight: 60g of lysimachia christinae hance, 45g of radix isatidis, 25g of mirabilite, 70g of fructus forsythiae, 40g of radix scutellariae, 15g of aristolochiae lignum, 7g of radix bupleuri, 15g of root of red-rooted salvia, 12g of rhizoma corydalis, 7g of nutgrass galingale rhizome, 12g of fructus toosendan, 20g of angelica, 7g of radix paeoniae alba, 5g of poncirus trifoliate, 25g of curcuma aromatica, 10g of fingered citron, 30g of radix astragali, 15g of chrysanthemum, 15g of felwort, 30g of serrate rabdosia herb, 7g of oriental wormwood, 27g of plantain herb, 10g of rhizoma alismatis, 16g of talcum, 5g of liquorice, 20g of lygodium japonicum, 25g of gardeniae, 15g of curcuma zedoary, 10g of amur cork tree bark, 20g of costus root, 22g of silybum marianum, 8g of poria cocos, 25g of dendrobe, 35g of hawthorn and 20g of pericarpium arecae. The medicine for treating gallstones has the advantages of being free from side effect, low in price, high in recovery rate, low in recurrence rate and rapid to become effective.

The invention discloses a cholelithiasis treatment drug, and belongs to the technical field of traditional Chinese medicines. The cholelithiasis treatment drug is prepared from three groups of bulk drugs, wherein the first group of the drugs comprises japanese climbing fern spore, cape jasmine, submature bitter orange, common burreed tuber, blue turmeric rhizome, rheum, christina loosestrife herb, amur corktree bark, Chinese thorowax root, salvia miltiorrhiza and chicken's gizzard-membrane, the second group of the drugs comprises Chinese thorowax root, christina loosestrife herb, amur corktree bark, white peony root, chicken's gizzard-membrane, silybum marianum, costusroot, corydalis tuber, salvia miltiorrhiza, tuckahoe, asiatic plantain seed, wenchow turmeric root tuber, Japanese climbing fern spore, submature bitter orange and cape jasmine, the third group of the drugs comprises Chinese thorowax root, salvia miltiorrhiza, finger citron fruit, noble dendrobium stem herb, baikal skullcap root, dangshen, tuckahoe, areca peel, common jujube, largehead atractylodes rhizome, milkvetch root, common yam rhizome, immature tangerine fruit, angelica, villous amonmum fruit, hawthorn and licorice root, the first group of the drug is continuously taken 10-20 days, the second group of the drug is continuously taken 10-20 days, and the third group of the drug is continuously taken 5-8 days. According to the present invention, cholelithiasis treatment is divided into three stages, an effective rate is 100%, and recurrence is not easily generated after disease treatment.

The invention discloses a device for detecting the quality of a Silybum marianum seed, which belongs to non-destructive testing technology for the quality of raw material of traditional Chinese medicine. The device comprises a spectrum signal collecting system and a microprocessor electrically connected with the spectrum signal collecting system; wherein the spectrum signal collecting system is used for spectral scan for Silybum marianum seeds to be tested, collecting diffuse reflection near-infrared signals of the Silybum marianum seeds to be tested and then transmitting the signals to the microprocessor. The invention further discloses a method for detecting the quality of Silybum marianum seeds. The invention applies the near-infrared optical detection means to the process of non-destructive testing technology for the quality of raw material of traditional Chinese medicine, therefore the method has the advantages of high detecting precision, good consistency of results and high automation degree. The time for conducting one-time detection would not exceed one minute, therefore the invention can be conveniently applied to on-site quality detection of the primary raw material of tradition Chinese medicine so as to comprehensively evaluate the quality of the Silybum marianum seeds with great efficiency.

The invention discloses a composite feed capable for improving the intestinal health of tilapia. The composite feed is obtained by mixing Chinese herbal medicine extracts and basic ingredients, and drying the mixture, wherein the weight ratio of the basic ingredients to the Chinese herbal medicine extracts is (995 to 999): (1-5); each 1 to 5 L of the Chinese herbal medicine extracts is obtained by conducting water extraction on the following Chinese herbal medicine: 2 to 10 g of panax notoginseng, 3 to 15 g of shizandra berry, 5 to 20 g of astragalus membranaceus,5 to 15 g of liquorice, 2 to 10 g of radix notoginseng, 6 to 18 g of lithospermum, 5 to 15 g of silybum marianum, and 2 to 10 g of fructus psoraleae. The composite feed is used for tilapia culture, and can be used for improving the intestinal health of tilapia, and the non-specific immunity of the organism of tilapia. The invention further provides a preparation method of the composite feed.

The invention discloses a preparation method and application of a microorganism feed for milk thistle silybum marianum meal. The preparation method comprises the following steps of adding acid protease, cellulases, xylanase, mannase, alpha-galactosidase, beta glucanase and phytase to the milk thistle silybum marianum meal, adding calcium hydrogen phosphate, performing uniform stirring, and performing first-stage fermentation with bacillus and microzymes; and then adding lactic acid bacteria and bifidobacteria, and then performing second-stage anaerobic fermentation in a one-way membrane anaerobic bag to obtain finished products of the microorganism feed. The content of viable bacteria is increased, and the preparation raw materials are free from sterilization. The prepared products are free from drying treatment, and the production cost is reduced. The finished products of the microorganism feed contain rich functional substances of viable bacteria, enzyme groups, vitamins, lipid, organic acid, amino acids, various oligosaccharide and coenzyme factors, small peptide and the like, and are few in infectious microbes and obvious in feeding effects. The utilization efficiency of the feed is improved, the immunity and the resistance of the fed objects are effectively improved, the microorganism feed can be used for replacing antibiotics, the quality of animal products is further improved, the fetor of fence shed is eliminated, and the ecological benefits are obvious.

The invention discloses a composite Chinese herbal feed additive premix for preventing and treating discoloration of Pelteobagrus fulvidraco, comprising following materials by weight: based on per ton of feed, 1200-2500g of rheum officinale, 300-1600g of root of red-rooted salvia, 500-350g of marigold, 1000-3000g of silybum marianum, 300-1800g of pseudo-ginseng, 600-2200g of radix scutellariae, 800-1200g of golden cypress, 1000-1500g of astragalus mongholicus, 1000-3000g of motherwort, 800-4000g of garlic and 1000-3000g of hawthorn, wherein the adding weight of the composite Chinese herbal feed additive premix in per ton of Pelteobagrus fulvidraco compound feed is 10-20kg. The premix is optimized after large-scale productive experiments in several years so as to be safe and effective in long-term use and has no toxic side effects; and the immune function and anti-stress capability of the Pelteobagrus fulvidraco cultivated on a high-density intensive condition can be notably improved. Many experiments show that the serum lysozyme activity, macrophage phagocytic ability and serum complement energy of the Pelteobagrus fulvidraco are improved after the Pelteobagrus fulvidraco eats feed with the additive premix. The bred Pelteobagrus fulvidraco has high survival rate, bright and natural body color, strong anti-stress capability and low feed coefficient.