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Method for producing aromatic amino compound

A method for producing aromatic amino compound (V):by synthesizing intermediate compound (IV):by the reaction of compound (I): H2N—R1 with a mixture of halogenated aryl compounds (II): Ar1—X and (III): Ar2—X in the presence of a noble metal catalyst, followed by eliminating the substituent R1 from the nitrogen atom in compound (IV) under an acidic condition or an alkaline condition or by addition of a reducing agent or an oxidizing agent. (R1: a substituent having 2 to 50 carbon atoms; Ar1 and Ar2: a substituted or unsubstituted hydrocarbon group or heterocyclic group having 6 to 50 carbon atoms and the same with or different from each other; and X: a halogen group). The aromatic amino compound useful as the charge transporting material can be produced efficiently at a great yield without using highly toxic raw materials.
Owner:IDEMITSU KOSAN CO LTD

Method and tools for oral hygiene

A method and material for self-cleaning of the teeth and mouth using a source of light in the visible range in conjunction with a photosensitive oral hygiene composition possessing a broad absorption spectrum in the visible range. The invention selectively eliminates harmful bacteria by use of a photosensitive agent and a light source. The present invention involves the use of a light-providing dental device to activate a photosensitive agent and destroy harmful bacteria in the oral cavity. It prevents or deters oral diseases, inflammations, and infections.
Owner:BIOLITEC UNTERNEHMENSBETEILLIGUNGS II AG

Cleaning apparatus using photocatalyst

Cleaning apparatus includes a cleaning head, a light source and a light guide. The cleaning head has a flexible contact member including photo-activating catalyst (photocatalyst). The light source emits short wave light rays to activate the photocatalyst. The light guide transmits the light rays from the light source to the contact member(brushes). The cleaning head may have a transparent brush supporter to support a group of brushes with many photocatalyst particles. The light guide may preferably include a transparent rod and / or an optical fiber. The cleaning apparatus may be applied for a vacuum cleaner. Therefore, such dirty component can be cleaned as bacteria, molds etc. by use of the cleaning apparatus of the invention.
Owner:IIMURA KEIJI

Layered-modeling device and method using said device for manufacturing three-dimensional objects

An object of the present invention is to easily eliminate fumes inside a chamber, so as to improve a positional accuracy of irradiation with a light beam and a machining accuracy in a method for manufacturing a three-dimensional shaped object. A stacked-layers forming device 1 includes a powder layer forming unit 3, a light beam irradiating unit 4, a base 22 which is fixed and on which a powder layer 32 is formed, a lifting / lowering frame 34 which surrounds the circumference of the base 22 and is freely capable of being lifted and lowered, a cover frame 36 which has a window 36a allowing transmission of light beam in its top surface, and whose bottom surface is opened, and which is disposed on the lifting / lowering frame 34 to form a chamber C, and a gas tank 71 for supplying an ambient gas. The lifting / lowering frame 34 is lowered to reduce the volume of the chamber C, so as to discharge fumes generated inside the cover frame 36, which performs replacement with the ambient gas. Since the volume of the chamber C is reduced, it is possible to easily eliminate the fumes, which makes it possible to improve the positional accuracy of irradiation with the light beam L, and the machining accuracy.
Owner:PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO LTD

Methods and devices to curb appetite and/or to reduce food intake

The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and / or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal / duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.
Owner:ENDOSPHERE

Online Systems and Methods for Advancing Information Organization Sharing and Collective Action

ActiveUS20170024091A1Conveniently and selectively engageHighly organized and efficient bilateralInformation formatServices signallingKnowledge organizationMobile device
Methods and systems and mobile device interfaces for creating, joining, organizing and managing via mobile devices affinity groups in a cloud computing environment for social and business purposes.
Owner:HOSIER JR GERALD DOUGLAS

Full scale calibration measurement for multi-touch surfaces

Normalization of regions of a sensor panel capable of detecting multi-touch events, or a sensor panel capable of detecting multi-hover events, is disclosed to enable each sensor in the sensor panel to trigger a virtual button in a similar manner, given the same amount of touch or hover. Each sensor produces an output value proportional to the level or amount of touch or hover. However, due to processing, manufacturing and physical design differences, the sensor output values can vary from region to region or panel to panel for a given amount of touch or hover. To normalize the sensor output values across regions, gain and offset information can be obtained in advance, stored in nonvolatile memory, and later used to normalize the sensor output values so that all regions in the sensor panel can trigger virtual buttons similarly, providing a uniform “response function” at any location on the sensor panel.
Owner:APPLE INC

Single column layout for content pages

A system and method for small computing devices that present a single column of content such as a web page such that a user need only scroll vertically to see the content. A parser converts HTML to CSS as necessary, and a single column style sheet modifies content for a more-optimized viewing experience. To this end, tables and tables cells are rendered as blocks, with no padding / border / margins and any explicit widths and heights changed to automatic. Other table elements are rendered as block level elements, and horizontal margins are eliminated or re-enabled on some elements in a reduced manner. Spacer images are removed, as well as cell background images and small images. Content such as text is wrapped, and images are resized as necessary based on the screen display width. The result is a single content column that facilitates viewing and scrolling in only one direction.
Owner:MICROSOFT TECH LICENSING LLC

Wireless communication of physiological variables

The present invention relates to a system and a method of measuring a physiological variable in a body. A basic idea of the present invention is to measure a physiological variable in a body by means of employing a sensor (314) which is arranged to be disposed in the body for measuring the physiological variable. The sensor must be provided with a supply voltage in order to be operable. Therefore, a control unit (322) disposed outside the body provides this supply voltage to the sensor. The control unit also receives, from the sensor, via a wired connection (311), signals that represent the physiological variables that are measured. The control unit is arranged with a communication interface (401, 701) and a modulator (301) for wireless communication of the measured physiological variables for presentation purposes.
Owner:ST JUDE MEDICAL COORDINATION CENT

Apparatus, methods and storage medium for performing polarization-based quadrature demodulation in optical coherence tomography

Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample and at least one second electromagnetic radiation to a reference, such that the first and / or second electromagnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation associated with the first radiation can be combined with a second polarization component of at least one fourth radiation associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another.
Owner:THE GENERAL HOSPITAL CORP

Methods of treating acute myeloid leukemia by blocking CD47

Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Notched electrode for electrostimulation lead

According to one embodiment, an electrode for use in electrostimulation is provided, where the electrode comprises a notch that operates to substantially eliminate gaseous material from being trapped about the electrode during a molding process of an electrostimulation lead.
Owner:ADVANCED NEUROMODULATION SYST INC

Isolation and purification of antibodies using protein a affinity chromatography

ActiveUS20100135987A1Easy to disassembleReduce or inactivate pH-sensitive virusesAntipyreticAnalgesicsIon exchangeAntibody Affinity Chromatography
Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction / inactivation, ultrafiltration / diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention.
Owner:ABBVIE INC

Thrombectomy catheter

InactiveUS20070250096A1Reduction in cross-sectional area of lumenLimited rangeCannulasExcision instrumentsThrombusCatheter device
A catheter includes a flexible elongate catheter tube having a distal end, a proximal end, and a lumen defined therein, the proximal end being connectable to a suction device for evacuating the lumen, and a thrombus cutter disposed in the catheter tube near the distal end thereof, the thrombus cutter including at least one cutting edge directed radially inward from an inner wall surface of the lumen
Owner:TERUMO KK +1

Method and tools for oral hygiene

A method and material for self-cleaning of the teeth and mouth using a source of light in the visible range in conjunction with a photosensitive oral hygiene composition possessing a broad absorption spectrum in the visible range. The invention selectively eliminates harmful bacteria by use of a photosensitive agent and a light source. The present invention involves the use of a light-providing dental device to activate a photosensitive agent and destroy harmful bacteria in the oral cavity. It prevents or deters oral diseases, inflammations, and infections.
Owner:BIOLITEC UNTERNEHMENSBETEILLIGUNGS II AG

Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents

This patent discloses the synthesis of a multi-block copolymer containing poly(amino acids) (PAA) and a hydrophilic polymer which are degradable under physiological conditions. Control over the degradation rate of the obtained copolymers is achieved by introducing ester, amide or urethane groups as a biodegradable linkage connecting the PAA and the hydrophilic polymer. The biodegradable multi-block copolymers display high transfection efficiency in plasmid delivery with low cytotoxicity.
Owner:EXPRESSION GENETICS INC

Fluorochemical composition comprising a fluorinated polymer and treatment of a fibrous substrate therewith

A fluorochemical composition for rendering fibrous substrates oil repellent, water repellent, and / or stain repellent and comprising a fluorinated polymer dispersed in water or dissolved or dispersed in an organic solvent, the fluorinated polymer comprising units derived from (i) a mixture of two or more fluorinated polyether monomers that differ in at least their molecular weight, the fluorinated polyether monomers having an ethylenically unsaturated group and a perfluorinated polyether group and wherein at least 90% by weight of the mixture consists of fluorinated polyether monomers that have a perfluorinated polyether group having a molecular weight of at least 750 g / mol and (ii) one or more units derived from one or more co-monomers other than a fluorinated polyether monomer and wherein the co-monomers comprise at least one non-fluorinated monomer. Also, method for treating fibrous substrate with such composition, fluorinated polyether monomers, and fluorinated polymers derived from such monomers.
Owner:3M INNOVATIVE PROPERTIES CO

Indirect supplemental evaporation cooler

A cooler for an air conditioning system or other system having a heated surface to be cooled has an array of nozzles for issuing a fine spray of liquid. A fan of the cooler induces flow of air over a surface to be cooled, the nozzles issuing into the flow of air the fine spray at a distance from the heated surface such that the liquid of the fine spray is fully evaporated prior to contact with the heated surface. Drop sizes of 20 to 30 microns are typical.
Owner:X NTH INC

Seed meter monitoring system

A detector is supported adjacent the seed cells within a seed meter housing and provides an indication of the presence or absence of seeds in the cells. A processor receives the seed presence indications and provides an operator readout to facilitate adjustments to the seed meter system to maintain a single seed per seed cell at the given seed population. In one embodiment, the detector is a video camera and the readout includes a slow motion rendering of the seed cells downstream of a seed singulator. In another embodiment, a light source is located on one side of the seed cells, and a light detector is located on the opposite side of the seed cell to determine presence or absence of material in the cell.
Owner:DEERE & CO

Methods of treatment using ammonia-scavenging drugs

The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and / or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.
Owner:HORIZON THERAPEUTICS LLC

Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae

The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
Owner:NOVARTIS VACCINES & DIAGNOSTICS INC

Airborne reconnaissance system

An airborne reconnaissance system comprising: (1) Gimbals having at least two degrees of freedom; (2) At least one array of light sensors positioned on the gimbals, for being directed by the same within at least two degrees of freedom; (3) Map storage means for storing at least one Digital Elevation Map of an area of interest, divided into portions; (4) Inertial Navigation System for real-time providing to a gimbals control unit navigation and orientation data of the aircraft with respect to a predefined global axes system;(5) Portion selection unit for selecting, one at a time, another area portion from the area of interest; and (6) servo means for directing the gimbals. The system uses data from the inertial navigation system and from the digital elevation map for real-time calculating direction to selected area portions, and for maintaining the direction during integration of light from the terrain, and for producing corresponding images of area portions.
Owner:THE STATE OF ISRAEL MINIST OF AGRI & RURAL DEV AGRI RES ORG ARO VOLCANI CENT

Fluorine-Containing Compound, Fluorine-Containing Polymer, Postive-Type Resist Composition, And Patterning Process Using Same

Disclosed is a fluorine-containing compound represented by formula (1),wherein R1 represents a polymerizable double-bond containing group, R2 represents an acid-labile protecting group, R3 represents a fluorine atom or fluorine-containing alkyl group, and W represents a bivalent linking group. This compound can provide a fluorine-containing polymer compound that has a weight-average molecular weight of 1,000-1,000,000 and contains a repeating unit represented by formula (2),wherein R2, R3 and W are defined as above, each of R4, R5 and R6 independently represents a hydrogen atom, fluorine atom or monovalent organic group, at least two of R4, R5 and R6 may be combined to form a ring. This polymer compound can provide a resist composition capable of forming a pattern that is transparent to exposure light and superior in rectangularity.
Owner:CENT GLASS CO LTD

Device and method for controlling an automatic steering system of a vehicle, and device and method for checking the ability to implement a predefined setpoint travel direction variable for a vehicle

A device for controlling an automatic steering system of a vehicle includes a signal input (which receives a setpoint travel direction variable, a memory device on which a correction factor is stored, a control unit which ascertains a corrected setpoint travel direction variable on the basis of the correction factor and the predefined setpoint travel direction variable, and an evaluation device which compares an actual travel direction variable ascertained by a sensor of the vehicle to the predefined setpoint travel direction variable, and if the actual travel direction variable deviates from the predefined setpoint travel direction variable by at least a minimum difference, redefines the correction factor according to the comparison.
Owner:ROBERT BOSCH GMBH

Methods for Manipulating Phagocytosis Mediated by CD47

Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Optical apparatuses using the near-field light

Optical apparatuses are provided that use near-field light, where high spatial resolution and high sensitivity are made compatible. Highly intense near-field light is generated in a narrow area using localized plasmons that are produced in a metal pattern 106 in a shape that bears anisotropy and is made to irradiate a measured subject. The direction of polarization 104 of incident light 103 is modulated and signal light is subjected to synchronous detection, so that background light is removed and high sensitivity is achieved.
Owner:HITACHI LTD
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