Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof

A technology with luminescent properties and magnetic properties, which can be used in medical preparations of non-active ingredients, preparations for in vivo experiments, drug delivery, etc. It can solve the problems of disintegration and release, poor thermal stability and chemical stability, and achieve easy operation , good water solubility and good biocompatibility

Active Publication Date: 2011-02-09
中国科学院上海硅酸盐研究所苏州研究院
View PDF8 Cites 42 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the inherent characteristics of organic materials, it was found during the research that these organic carrier systems inevitably have

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof
  • Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof
  • Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0038] Example 1: Preparation of β-FeOOH nanoparticles

[0039] Using hydrothermal method, 4mmol FeCl 3 ·6H 2 O and 1.0 g of polyvinylpyrrolidone (PVP, K-30) were dissolved in 70 mL of deionized water, transferred to a 100 mL stainless steel hydrothermal kettle with a polytetrafluoroethylene liner, and placed in an oven at 100°C for 10 hours. Take it out, cool to room temperature, centrifuge, wash 3 times with water, and vacuum dry at room temperature for 36 hours to obtain spindle-shaped β-FeOOH nanoparticles.

[0040] The TEM image of the material obtained in Example 1 is as follows figure 1 As shown in the figure, the average length of the nanoparticles is 180nm; the average diameter is 53nm; figure 1 The illustration in (b) is figure 1 The selected area electron diffraction pattern of a β-FeOOH nanoparticle in (b) shows that the nanoparticle has a single crystal structure. XRD spectra such as image 3 (a) shows that the β-FeOOH nanoparticles obtained in Example 1 have a tetrago...

Example Embodiment

[0041] Example 2: β-FeOOH surface coated with alkyl chain-containing SiO 2 Of nanocomposite core-shell materials

[0042] Using the sol-gel method, 100 mg of β-FeOOH nanoparticles obtained in Example 1 were uniformly dispersed in a mixed solution of 50 mL of water and 250 mL of isopropanol, 7.5 mL of ammonia was added, and then a total volume of 0.4 mL of ortho silicon was added dropwise Tetraethyl orthosilicate and octadecyltrimethoxysilane, after the addition, continue to stir for 3h, then centrifuge, the solid is washed 3 times with ethanol, and finally vacuum dried at room temperature for 24h; Tetraethylorthosilicate and octadecyl The ratio of the amount of trimethoxysilane is 4.7.

[0043] The TEM image of the material obtained in Example 2 is as figure 2 (a) shows that the surface of β-FeOOH obtained in Example 2 is coated with SiO containing alkyl chains 2 The composite core-shell nanoparticles have a core-shell structure, and the average thickness of the shell is 25nm. XR...

Example Embodiment

[0044] Example 3: α-Fe 2 O 3 @mSiO 2 Preparation of hollow nanocomposite capsules

[0045] The surface of β-FeOOH obtained in Example 2 was coated with SiO containing alkyl chains 2 The composite core-shell nanoparticles are heat-treated in the air at 550°C for 6 hours to remove the pore former and at the same time transform the core from β-FeOOH to α-Fe 2 O 3 , Thereby creating a cavity in the inner core to form a hollow nanocapsule structure; the heating rate of the heat treatment is 1°C / min.

[0046] The TEM image of the material obtained in Example 3 is as follows figure 2 (b) shows that the α-Fe obtained in Example 3 2 O 3 @mSiO 2 The nanocomposite capsule has a cavity structure with α-Fe inside 2 O 3 It has a hollow nanocapsule structure, and the outside of the wall is tightly attached to the inner wall of the mesoporous silica. XRD spectra such as image 3 (c) shows that the α-Fe obtained in Example 3 2 O 3 @mSiO 2 The structure of β-FeOOH no longer exists in the nanocomposi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Lengthaaaaaaaaaa
Diameteraaaaaaaaaa
Thicknessaaaaaaaaaa
Login to view more

Abstract

The invention discloses a hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance. In the medicament carrying system, a magnetic Fe3O4 hollow capsule is used as an inner core, mesoporous SiO2 is used as a shell layer, and an organic luminescent material and a biocompatible polymer are modified on the outer surface of the shell layer. A preparation method of the medicament carrying system comprises the following steps of: firstly, preparing monodisperse fusiform beta-FeOOH nanoparticles by a hydro-thermal method, coating mesoporous silicon dioxide on the surfaces of the nanoparticles, removing a pore-forming agent through thermal treatment, and simultaneously, converting the inner core into alpha-Fe2O3 from the beta-FeOOH, so that a cavity is generated in the inner core so as to form a hollow nanometer capsule structure; secondly, converting the inner core into the magnetic Fe3O4 hollow capsule through reduction treatment; and finally, modifying the organic luminescent material and the biocompatible polymer on the surface of the magnetic mesoporous nanometer capsule. The nanometer composite capsule of the invention has the advantages of core-shell structure and cavity structure, uniform particle size, high biocompatibility and excellent magnetism.

Description

technical field [0001] The invention relates to a nano imaging material and a nano medicine-carrying material, in particular to a hollow core-shell nano mesoporous drug-carrying system with a cavity structure in a magnetic inner core, which has magnetic and luminous properties, and its preparation and application. Background technique [0002] Malignant tumor is the number one "killer" that endangers human existence. The development of new technologies for early diagnosis of malignant tumors and the search for safe and effective antineoplastic drugs with high tumor targeting have become clinical problems to be solved urgently. [0003] Magnetic resonance imaging (MRI) technology is one of the most effective clinical diagnostic methods for rapid detection of early tissue cancer. Usually, in order to enhance the contrast between MRI images of cancerous tissue and normal tissue, it is necessary to select a suitable contrast enhancer to reveal anatomical features. Among the co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K49/18A61K47/34A61K47/22A61K47/04A61K49/08A61K49/10A61K49/12A61K47/02A61K47/10
Inventor 吴惠霞施剑林
Owner 中国科学院上海硅酸盐研究所苏州研究院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap