Amphiphilic ternary polymer brush and nano capsule

A ternary molecular brush and polymer technology, applied in microcapsule preparations, microsphere preparation and other directions, can solve the problems of harsh conditions and difficult block copolymers, and achieve simple operation, easy size adjustment and controllability, and environmental protection. friendly effect

Active Publication Date: 2013-02-06
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, it is difficult to synthesize block copolymers with complex structures, and the conditions are relatively harsh, which limits the self-assembly method to prepare capsules with diverse properties.

Method used

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  • Amphiphilic ternary polymer brush and nano capsule
  • Amphiphilic ternary polymer brush and nano capsule
  • Amphiphilic ternary polymer brush and nano capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] An amphiphilic ternary molecular brush polymer is prepared by the following steps:

[0044] (1) P(GMA-N 3 ) main chain synthesis

[0045]Take 1 part of ethyl 2-bromoisobutyrate initiator, 200 parts of glycidyl methacrylate (GMA), 100 parts of diphenyl ether, 1 part of CuBr and 1 part of N,N,N',N',N" -Pentamethyldiethylenetriamine (PMDETA), carry out ATRP reaction at room temperature under the protection of nitrogen to obtain polyglycidyl methacrylate (PGMA) with a degree of polymerization (DP) of 40.

[0046] Take 100 parts of PGMA (DP=40), 100 parts of NaN 3 , 500 parts of dimethylformamide (DMF) and 1 part of AlCl 3 , reacted at 50°C for 24 hours to obtain P(GMA-N 3 ), as the main chain.

[0047] (2) Synthesis of three side chains

[0048] Synthesis of hydrophilic side chains: Take 100 parts of monomethoxypolyethylene glycol (Mn=5000), 20 parts of 2-propynylacetic acid, 20 parts of 4-dimethylaminopyridine (DMAP), 20 parts of 1-( 3-Dimethylaminopropyl)-3-ethylca...

Embodiment 2

[0057] The preparation method and raw material composition are the same as in Example 1, and only the main chain of the amphiphilic ternary molecular brush polymer in Example 1 and the degree of polymerization of the three side chains are adjusted to obtain nanocapsules with different particle sizes . The degree of polymerization of the main chain and three side chains, and the particle size of the nanocapsules are shown in Table 1.

[0058] Table 1: The effect of the main chain and side chain polymerization degree of molecular brushes on the particle size of nanocapsules

[0059]

[0060] It can be seen from Table 1 that nanocapsules with different particle sizes can be prepared by adjusting the degree of polymerization of the main chain and side chains.

Embodiment 3

[0062] The preparation method and raw material composition are the same as in Example 1, only changing the composition of the lipophilic side chain of the amphiphilic ternary molecular brush polymer in Example 1, and nanocapsules with different particle sizes can be prepared. The composition of the lipophilic side chain and the particle size of the nanocapsules are shown in Table 2.

[0063] Table 2: The influence of the lipophilic side chain composition of molecular brushes on the particle size of nanocapsules

[0064]

[0065] It can be seen from Table 2 that nanocapsules with different particle sizes can be prepared by changing the composition of lipophilic side chains.

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Abstract

The invention discloses an amphiphilic ternary polymer brush and a nano capsule. The amphiphilic ternary polymer brush has the following general formula, wherein A is polymer main chain, B is lipophilic polymer side chain, C is photo-crosslinked polymer side chain, D is hydrophilic polymer side chain, and the side chains B, C and D are randomly grafted onto the main chain A; and the nano capsule is prepared through dispersing the amphiphilic ternary polymer brush into an oil-water two-phase system, and then performing light crosslinking reaction or reaction initiated by light. The amphiphilic ternary polymer brush solves the difficulty that the particle size of the capsule can not be adjusted and controlled effectively by using the conventional segmented copolymers, and the size of the prepared photo-crosslinked nano capsule is easily adjusted and controlled; the nano capsule prepared by the emulsion self-assembly method is simple in operation and easy to use in large-scale preparation; the prepared hollow nano capsule is large in casting quantity; the photo-crosslinked nano capsule provided by the invention is stable, and according to the light crosslinking method, nontoxicity and safety are reliazed, and the environmental protection is realized. The amphiphilic ternary polymer brush has the following general formula: A-g-(B-r-C-r-D).

Description

technical field [0001] The invention belongs to the field of self-assembled polymer materials, and in particular relates to an amphiphilic ternary molecular brush polymer and nanocapsules prepared from the amphiphilic ternary molecular brush polymer. Background technique [0002] Typically, the size of nanocapsules is 1-1000 nm, which is several orders of magnitude smaller than that of microcapsules (1-2000 μm). Compared with microcapsules, nanocapsules have a higher specific surface area and exhibit special nano-effects. Due to the new characteristics produced by the special nano-effects of nanocapsules, nanocapsules can be used in high-tech fields such as drug sustained release, catalysis, bioengineering, and cosmetics. Due to the small size of nanocapsules, the synthesis is difficult. [0003] In recent years, with the emergence of new synthesis reaction technologies, such as controlled radical polymerization, point chemistry, etc., a large number of technologies for sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02B01J13/02
Inventor 胡继文刘锋刘国军林树东罗洪盛涂园园
Owner GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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