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Amphipathic ternary molecular brush polymer constructed multichannel nanocapsule

A ternary molecular brush and polymer technology, applied in microcapsule preparation, microsphere preparation and other directions, can solve the problems of difficult and harsh conditions of block copolymer, and achieve the effect of easy adjustment and control of size and simple operation.

Active Publication Date: 2014-11-19
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, it is difficult to synthesize block copolymers with complex structures, and the conditions are relatively harsh, which limits the self-assembly method to prepare capsules with stable multi-channel structures.

Method used

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  • Amphipathic ternary molecular brush polymer constructed multichannel nanocapsule
  • Amphipathic ternary molecular brush polymer constructed multichannel nanocapsule
  • Amphipathic ternary molecular brush polymer constructed multichannel nanocapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] An amphiphilic ternary molecular brush polymer is prepared by the following steps:

[0050] (1) P(GMA-N 3 ) main chain synthesis

[0051] Take 1 part of ethyl 2-bromoisobutyrate initiator, 200 parts of glycidyl methacrylate (GMA), 100 parts of diphenyl ether, 1 part of CuBr and 1 part of N,N,N',N',N" -Pentamethyldiethylenetriamine (PMDETA), conduct ATRP reaction at 30°C for 1 hour under nitrogen protection, and obtain polyglycidyl methacrylate (PGMA) with a degree of polymerization (DP) of 40.

[0052] Take 100 parts of PGMA (DP=40), 100 parts of NaN 3 , 500 parts of dimethylformamide (DMF) and 1 part of AlCl 3 , reacted at 50°C for 24 hours to obtain P(GMA-N 3 ), as the main chain.

[0053] (2) Synthesis of three side chains

[0054] Synthesis of hydrophilic side chains: Take 100 parts of monomethoxypolyethylene glycol (Mn=5000), 20 parts of 2-propynylacetic acid, 20 parts of 4-dimethylaminopyridine (DMAP), 20 parts of 1-( 3-Dimethylaminopropyl)-3-ethylcarbodiim...

Embodiment 2

[0064] The preparation method and raw material composition are the same as in Example 1, and only the main chain of the amphiphilic ternary molecular brush polymer in Example 1 and the degree of polymerization of the three side chains are adjusted to obtain nanocapsules with different particle sizes . The degree of polymerization of the main chain and three side chains, and the particle size of the nanocapsules are shown in Table 1.

[0065] Polymers with main chain polymerization degrees of 100, 300, and 500 and polymers with lipophilic side chain polymerization degrees of 150 and 300 can be prepared according to the method of Example 1 by controlling the polymerization reaction time. The grafting ratios of PEG, PAA, and PS side chains of each amphiphilic polymer molecular brush were 20%, 10%, and 20%, respectively.

[0066] Table 1: The effect of the main chain and side chain polymerization degree of molecular brushes on the particle size of nanocapsules

[0067]

[006...

Embodiment 3

[0070] The preparation method and raw material composition are the same as in Example 1, only changing the composition of the lipophilic side chain of the amphiphilic ternary molecular brush polymer in Example 1, nanocapsules with different particle sizes can be prepared. The composition of the lipophilic side chain and the particle size of the nanocapsules are shown in Table 2.

[0071] The preparation method of PtBA, PMMA, PCL, PLA, PMA, PVAc, and PAN with a degree of polymerization of lipophilic side chains of 30 is similar to that of PS, and is prepared by commonly used ARTP.

[0072] The grafting ratios of PEG, PAA, and lipophilic side chains of each amphiphilic polymer molecular brush were 20%, 10%, and 20%, respectively.

[0073] Table 2: The influence of the lipophilic side chain composition of molecular brushes on the particle size of nanocapsules

[0074]

[0075] It can be seen from Table 2 that nanocapsules with different particle sizes can be prepared by chang...

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Abstract

The invention discloses an amphipathic ternary molecular brush polymer and a nanocapsule. The amphipathic ternary molecular brush polymer has a general formula shown below, wherein A is a main polymer chain, B is a side lipophilic macromolecular chain, C is a side macromolecular chain with a hydrophilic chemical cross-linking structure, D is a side lipophilic macromolecular chain, and the side chains B, C and D are randomly grafted to the main chain A. The nanocapsule is obtained by dispersing the amphipathic ternary molecular brush polymer in an oil and water two-phase system for a chemical cross-linking reaction. The amphipathic ternary molecular brush polymer constructed multichannel nanocapsule, disclosed by the invention, solves the problem that a traditional segmented copolymer is difficult to adjust and control multiple channels of the nanocapsule efficiently; and the channel structure and size of the prepared nanocapsule are easy to adjust and controllable. As an emulsion self-assembling method is adopted for preparing the nanocapsule, simple operation is obtained and the nanocapsule is easy to prepare in a large scale; the prepared hollow nanometer nanocapsule covering amount is great; and the nanocapsule disclosed by the invention has a steady structure after hydrophilic chemical cross-linking. A-g-(B-r-C-r-D).

Description

technical field [0001] The invention belongs to the field of self-assembled polymer materials, and in particular relates to an amphiphilic ternary molecular brush polymer and a multi-channel nanocapsule prepared from the amphiphilic ternary molecular brush polymer. Background technique [0002] Generally, the size of nanocapsules is 1-1000 nm, which is several orders of magnitude smaller than the size of microcapsules (1-2000 μm). Compared with microcapsules, nanocapsules have a higher specific surface area and exhibit special nano-effects. Due to the new characteristics produced by the special nano-effects of nanocapsules, nanocapsules can be used in high-tech fields such as drug sustained release, catalysis, bioengineering, and cosmetics. Due to the small size of nanocapsules, the synthesis is difficult. [0003] In recent years, with the emergence of new synthesis reaction technologies, such as controlled radical polymerization, point chemistry, etc., a large number of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/02B01J13/02
Inventor 胡继文刘锋刘国军林树东侯成敏罗洪盛涂园园
Owner GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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